Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes
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Iron is an essential element for multiple metabolic reactions, but excessive iron accumulation in the brain can lead to astrocyte swelling and death and cause cerebral edema. Aquaporin-4 (AQP4) is the important water channel expressed in the astrocytes, and ma... ...
