Comparative evaluation of radiolabeled bombesin analogs [177Lu]Lu-AMBA and [177Lu]Lu-RM2 for targeting GRPR in glioblastoma model [0.03%]
放射标记的类Bombesin化合物[177Lu]Lu-AMBA和[177Lu]Lu-RM2在靶向胶质母细胞瘤模型中胃泌素释放肽受体的比较研究
Michal Grzmil,Muriel Aline Spahn,Philipp Berger et al.
Michal Grzmil et al.
Introduction: Radiolabeled agonist ligands bind to and activate target receptors, inducing internalization and delivering radionuclides into the inner cancer cells. In contrast, receptor-bound antagonizing radiopeptides i...
Preclinical evaluation of [225Ac]Ac-PSMA-617 and in vivo effect comparison in combination with [177Lu]Lu-PSMA-617 for prostate cancer [0.03%]
前列腺癌的[225Ac]Ac-PSMA-617的临床前评估及其与[177Lu]Lu-PSMA-617联合应用的体内效果比较
E Savio,L Reyes,J Giglio et al.
E Savio et al.
Introduction: The interest in targeted alpha therapy (TAT) has grown in the recent years as it can provide new treatment options for advanced- and late-stage cancer. In this sense, the use of actinium-225 is rising showin...
Exploration of the utilization of irreversible cysteine protease inhibitor in FAP-targeted radiopharmaceuticals design to increase tumor residence time [0.03%]
不可逆半胱氨酸蛋白酶抑制剂在FAP靶向放射性药物设计中增加肿瘤滞留时间的研究探索
Katie Brake,Audifás-Salvador Matus-Meza,Purnima Rawat et al.
Katie Brake et al.
Introduction: Fibroblast activation protein (FAP) is highly upregulated in the stroma of >90 % of epithelial cancers with restricted expression in normal tissues, making it an attractive drug target. Efforts by numerous l...
Radiochemistry of cyclen-derived chelators comprising five-membered azaheterocyclic arms with 212Pb2+, 213Bi3+, and 225Ac3 [0.03%]
含有五个氮杂环臂的cyclen衍生物螯合物与212Pb2+、213Bi3+和225Ac3+的放射化学研究
Ina Hierlmeier,Parmissa Randhawa,Brooke L McNeil et al.
Ina Hierlmeier et al.
In this work, we introduce the cyclen-based metal chelator DOTThia comprising four methylthiazole arms for metal complexation. Together with the recently described congener DOTI-Me bearing four methylimidazole arms, the radiochemistry of th...
Synthesis and evaluation of a 99mTc-labelled deuterated tropane derivative as a SPECT probe for dopamine transporter [0.03%]
一种新的99mTc标记的氘代生物碱衍生物作为合成代谢型单胺转运体SPECT显像剂的研究
Jing Kang,Jingwen Li,Chunyi Liu et al.
Jing Kang et al.
Introduction: The dopamine transporter (DAT) is intricately associated with a broad spectrum of neurological disorders including Parkinson's disease and various other neurodegenerative conditions. In vivo imaging DAT with...
Dmitry Filosofov,Ayagoz Baimukhanova,Jurabek Khushvaktov et al.
Dmitry Filosofov et al.
Targeted Alpha Therapy (TAT) holds significant promise as a localized treatment for cancer. Encouraging clinical results from using peptides and antibodies labeled with alpha emitters to treat patients with metastatic cancers, particularly ...
Carbon-11-labelling of the histone deacetylase 6 radioligand EKZ-001 [0.03%]
一种用于标记HDAC6放射配体EKZ-001的碳-11方法
Tetsuro Tago,Jun Toyohara
Tetsuro Tago
Purpose: Histone deacetylase 6 (HDAC6) is involved in microtubule stabilisation and protein degradation, and is attracting attention as a therapeutic target molecule for neurodegenerative diseases. [18F]EKZ-001 is a posit...
Enhancing the therapeutic index of [211At]YF2 with iodo pseudo carrier: A simple strategy for reducing accumulation in kidneys, salivary and lacrimal glands [0.03%]
用碘伪载体增强[YF₂]²¹₁At的治疗指数：一种减少肾脏、唾液腺和泪腺蓄积的简单策略
Truc T Huynh,Yutian Feng,Rebecca L Banks et al.
Truc T Huynh et al.
Introduction: Low-molecular-weight (LMW) PSMA-targeted agents have enjoyed success; however, their off-target toxicity in normal tissues such as kidneys, salivary gland and lacrimal gland can be dose limiting. Herein, we ...
Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats [0.03%]
评价放射薄层色谱作为放射HPLC的小鼠[18F]SynVesT-1代谢分析的替代方法
Tutukhanim Balayeva,Ruth H Asch,Peng Wen Tan et al.
Tutukhanim Balayeva et al.
Purpose: Alterations in synaptic vesicle glycoprotein 2A (SV2A) are linked to various neurodegenerative and neuropsychiatric disorders. Positron emission tomography (PET) imaging with radiotracers targeting SV2A, such as ...
Biodistribution and long-term toxicity of neutron-activated Samarium-153 oxide-loaded polystyrene microspheres in healthy rats [0.03%]
健康大鼠体内~(153)Sm中毒理学效应及长期毒性研究
Hun Yee Tan,Yin How Wong,Azahari Kasbollah et al.
Hun Yee Tan et al.
Purpose: Selective internal radiation therapy (SIRT) is an effective, minimally invasive treatment for intermediate and advanced-stage liver malignancies, particularly when other curative options are not viable. As an alt...