Preclinical characterization of a novel FAP-targeted PET tracer, [68Ga]Ga-CB6NT-FAPI [0.03%]
新型FAP靶向PET示踪剂[68Ga]Ga-CB6NT-FAPI的临床前特征化研究
Hye Yeon Seo,Hwa Sil Kim,Ran Ji Yoo et al.
Hye Yeon Seo et al.
Fibroblast activation protein (FAP) is an established target for molecular imaging of the tumor stroma. In this study, we report the development and preclinical evaluation of a novel FAP-targeted positron emission tomography (PET) tracer, [...
Development of angiostatin based radiopharmaceutical as a sensitive tool for detection of ATP synthase during acute vascular damage [0.03%]
基于angiostatin的放射性药物的发展作为检测急性血管损伤期间ATP合成酶的敏感工具
Ankon Das,Tikum Florence,Carolina Rego Rodrigues et al.
Ankon Das et al.
Background: Angiostatin (ANG) is an endogenously cleaved protein of the plasminogen-plasmin conversion pathway which is activated during tumor angiogenesis and oxidative stress. One of the hallmarks of sub-clinical oxidat...
Development of a novel xCT transporter imaging using a radiopharmaceutical with inhibitor-type compounds [0.03%]
开发一种使用放射性药物和抑制类型化合物的新型xCT转运蛋白成像技术
Kakeru Sato,Jundai Yamagagta,Yuka Hirayama et al.
Kakeru Sato et al.
Background: The cystine/glutamate antiporter xCT has attracted attention due to its role in maintaining redox homeostasis. Noninvasive techniques for visualizing xCT expression in tumors provide valuable diagnostic inform...
NMB Innovators Series Professor Dae Yoon Chi, Ph.D.: Understanding of 18F-chemistry and its applications toward drug developments used in diagnosis and therapeutics [0.03%]
NMB创新者系列Chi大云教授博士:氟-18化学研究及其在药物开发中的应用：诊断和治疗
Hee Seup Kil,Byung Chul Lee,Dong Wook Kim et al.
Hee Seup Kil et al.
Hongchao Zhang,Olof Eriksson,Matts Olovsson et al.
Hongchao Zhang et al.
Introduction: Endometriosis, affecting up to 10% of women, is a chronic estrogen dependent disorder where ectopic endometrial-like tissue causes pelvic pain and infertility. Endometriosis is challenging to diagnose due to...
Enhanced tumor retention of the novel LAT1-targeting PET probe [18F]FAMT-OMe: A comparative study with [18F]FAMT in glioma mouse models [0.03%]
新型LAT1靶向PET探针[18F]FAMT-OMe在肿瘤中的滞留增强：与[18F]FAMT在胶质瘤小鼠模型中的比较研究
Thosapol Sampunta,Tadashi Watabe,Sadahiro Naka et al.
Thosapol Sampunta et al.
Introduction: [18F]fluoro-L-α-methyltyrosine ([18F]FAMT) has been reported as a positron-emission tomography (PET) probe that has high specificity for L-type amino acid transporter 1 (LAT1), which is overexpressed in var...
Automated cassette-based synthesis, metabolism, and dosimetry of [18F]ApaScan, a PET tracer for aldosterone synthase imaging [0.03%]
自动化的卡式盒基于合成、代谢及[18F]ApaScan剂量学PET追踪物成像醛固酮合成酶影像研究
Yuki Shimizu,Toko Otaka,Miho Shidahara et al.
Yuki Shimizu et al.
Introduction: Aldosterone-producing adenomas (APAs) account for most cases of primary aldosteronism (PA), a major cause of secondary hypertension and hypokalemia. Although adrenal vein sampling (AVS) is the diagnostic gol...
Development of a new 18F-labeled PET tracer for potential application to HDAC2 neuroimaging [0.03%]
一种新的用于组蛋白去乙酰酶2神经影像潜在应用的氟-18标记正电子发射断层显像剂的研发
Yafei Huang,Yongle Wang,Yanli Wang et al.
Yafei Huang et al.
Histone deacetylases (HDACs) play an important role in the regulation of cellular functions and have attracted highly attention as promising therapeutic targets for the treatment of neurodegenerative diseases. Among the various HDAC isoform...
Sharon L Samuel,Solana Fernandez,Shelbie J Cingoranelli et al.
Sharon L Samuel et al.
Objective: This study aims to characterize and compare the saturation limits, spatial resolution, and image quality of various conventional and emerging positron-emitting radionuclides using a preclinical PET/CT scanner. ...