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Predictive tumor dosimetry and pharmacokinetic evaluation of [67Cu]Cu-rhPSMA-10.1 and [68Ga]Ga-rhPSMA-10.1 with PET/SPECT MRI in an orthotopic mouse model of glioblastoma

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Targeted radionuclide therapy (TRT) is an emerging pillar of precision medicine, with prostate-specific membrane antigen (PSMA)-targeted agents like [177Lu]PSMA-617 demonstrating notable clinical success. Achieving optimal therapeutic efficacy while minimizing... ...