Spontaneous association of different forms of non-conjugated astatine-211 to serum albumin [0.03%]
不同形式的非偶联砹-211与血清白蛋白的自发结合
Emma Aneheim,Sture Lindegren,Holger Jensen et al.
Emma Aneheim et al.
Aim/introduction: Astatine-211 is one of the alpha-particle emitting nuclides investigated for use within Targeted Alpha Therapy (TAT) of disseminated cancer. In previous studies, a difference in blood clearance has been ...
Mesothelin-targeted alpha therapy in PDAC with [225Ac]Ac-Macropa-PEG6-Amatuximab [0.03%]
锕-225标记的Macropa-amatuximab靶向治疗人源PDAC异种移植模型中的间皮素阳性肿瘤
Syed Qaiser Shah,Ralph Santos-Oliveira,Madeeha Shabnam et al.
Syed Qaiser Shah et al.
Pancreatic ductal adenocarcinoma (PDAC) continues to be deadly and resistant to traditional treatments. Overexpressed in >80% of PDACs, mesothelin is an ideal target for antibody-based α-therapy. Actinium-225 (225Ac) produces high-LET α-p...
Implemented one-pot two step fully automated synthesis of [18F]FPIA for metabolic imaging applications [0.03%]
用于代谢成像应用的[18F]FPIA一键两步全自动合成法的成功实现
José S Enriquez,Vincenzo Paolillo,Ryan Armijo et al.
José S Enriquez et al.
Background: [18F]Fluoropivalate ([18F]FPIA), also known as 18F-pivalate or 18F-RAD101, is the fluorinated analogue of pivalic acid and has shown promise in ongoing clinical trials for the detection of brain metastases. Th...
Development of an automated one-step radiolabeling procedure for a PSMA-targeted radiotherapeutic for prostate cancer [0.03%]
前列腺癌PSMA放射治疗药物的自动一步法放射标记程序的研发
Meltem Ocak,Kanishka Sikligar,Michael Pun et al.
Meltem Ocak et al.
Background: CTT1403 (177Lu-CTT2001), an irreversible phosphoramidate PSMA inhibitor developed by Cancer Targeted Technology, was initially synthesized using a two-step radiolabeling method and has previously been evaluate...
H3RESCA chelator-enabled [18F]AlF labeling: An optimized temperature-resilient platform for PSMA-targeted PET tracers in prostate cancer [0.03%]
H3RESCA配体导向的[18F]AlF标记：前列腺癌PSMA靶向PET示踪剂的优化和耐温性平台
Yukai Zhang,Zhoumi Hu,Qingyu Zhang et al.
Yukai Zhang et al.
Objective: Prostate-specific membrane antigen (PSMA) has emerged as a pivotal biomarker for the molecular imaging and targeted therapy of prostate cancer. To address the ongoing need for PSMA-targeting radiotracers with i...
In vitro evaluation of anti-HIV radioimmunoconjugates labeled with astatine-211, thorium-227 and actinium-225 [0.03%]
211At、227Th和225Ac标记的抗HIV放射免疫结合物的体外评价研究
Anne-Sophie Kuhlmann,Donald K Hamlin,Yawen Li et al.
Anne-Sophie Kuhlmann et al.
We conducted an in vitro investigation of the selective cytotoxicity of alpha-emitting radioimmunoconjugates (α-RICs) directed against cells expressing HIV envelope (Env) proteins. It is well known that monoclonal antibody (mAb)-targeted ...
Substitution matters: Comparison of four N,1,4-tri(methoxy-2-hydroxybenzyl)-DAZA ligands as potential PET/CT liver imaging agents [0.03%]
N,1,4-三(甲氧基-2-羟基苯基)乙二胺配体取代效应对潜在肝脏PET/CT显像剂的药代动力学影响研究
Anne Zenner,Thomas Winkens,Marta Pomraenke et al.
Anne Zenner et al.
Four regioisomers of [68Ga]Ga-TMoS-DAZA, a PET/CT radio tracer for liver function imaging, were studied as candidates of potentially improved hepatobiliary biokinetics. Liver uptake and biliary clearance behavior were compared using an in o...
C-H (radio)fluorination of hydroxamides via strained and electronically tunable α-lactams enabled by N-O scission [0.03%]
通过N=O键断裂实现的环张力及电子可调α- lactam介导的羟胺酸的C-H/(Radio)氟化反应
Siran Qian,Surendra Reddy Gundam,Carol Garcia et al.
Siran Qian et al.
Positron emission tomography (PET) fluorine-18 radiosynthesis primarily relies on operationally robust, albeit scope-limited methodologies. Therefore, a marked scientific need remains for new PET-compatible labelling protocols to expand rad...
Kinetic modelling and evaluation of the TrkA/B/C radioligand [18F]TRACK in the pig brain [0.03%]
标记追踪在猪脑中的动力学模型及评估研究
Cassis Varlow,Clara A Madsen,Carolin Jaworski et al.
Cassis Varlow et al.
Tropomyosin receptor kinase B (TrkB) is a critical mediator of neuronal growth, survival, and synaptic plasticity, which is activated by the endogenous ligand, brain-derived neurotrophic factor (BDNF). TrkB has been implicated in a wide ran...
Rodent biodistribution and dosimetry of the PET radioligands [18F]CHDI-385 and [18F]CHDI-386 targeting mutant huntingtin aggregates [0.03%]
针对突变亨廷顿蛋白聚集体的正电子发射断层扫描放射配体[18F]CHDI-385和[18F]CHDI-386在啮齿类动物中的生物分布与剂量学研究
Jordy Akkermans,Alan Miranda,Jeroen Verhaeghe et al.
Jordy Akkermans et al.
Background: Huntington's disease is a neurodegenerative condition resulting from an expanded CAG repeat in the huntingtin gene that produces a mutant form of the huntingtin protein (mHTT). In this study we estimated the r...