Estimation of the binding potential of the PET ligand [18F]FEDAC to translocator protein 18 kDa (TSPO) in the brain of experimental stroke model rats [0.03%]
估算实验性脑卒大鼠模型大脑中正电子发射断层显影配体[18F]FE-DAM与18kD转位蛋白的结合率
Tomoteru Yamasaki,Yiding Zhang,Wakana Mori et al.
Tomoteru Yamasaki et al.
Purpose: Translocator protein 18 kDa (TSPO) is a biomarker for neuroinflammation, and [18F]FEDAC was developed as a clinically usable radioligand for its imaging. Here, quantitative PET analyses of [18F]FEDAC in the brain...
Recent advances in understanding and improving the stability of 211At-radiopharmaceuticals [0.03%]
近期关于211At放射性药物稳定性的研究进展与改进措施
Romain Fouinneteau,Nicolas Galland,Cécile Perrio et al.
Romain Fouinneteau et al.
Astatine-211 is more than ever a serious candidate radionuclide to achieve success of targeted alpha therapy of cancers in the close future. However, several challenges remain to be overcome in order to guarantee the translation of 211At-la...
Radiolabelling bacteria with 89Zr-DBN for PET/MRI: comparing [89Zr]Zr oxalate and [89Zr]Zr phosphate [0.03%]
放射性标记细菌进行正电子发射断层扫描/磁共振成像(PET/MRI)：89Zr-DBN的草酸盐与磷酸盐比较研究
Diksha,Sarah C Donnelly,Mojmir Suchy et al.
Diksha et al.
Purpose: Our bodies host a diverse and complex community of bacteria, known as the microbiota, which play a crucial role in overall wellness. The gut microbiota perform essential functions, such as food fermentation, path...
Corticolimbic activation patterns during aversive audiogenic stress assessed by cerebral perfusion using [99mTc]HMPAO SPECT/CT [0.03%]
使用[99mTc]HMPAO SPECT/CT评估听觉应激期间的脑血流模式以观察皮层边缘系统的激活模式
Angel Moldes-Anaya,Lorenzo Ragazzi,Torgil R Vanberg et al.
Angel Moldes-Anaya et al.
Background: Emotional experiences modulate behavior by influencing the central and peripheral nervous systems, playing a crucial role in the pathophysiology of neuropsychiatric disorders. This study investigates the neura...
Preclinical evaluation and dosimetry of [64Cu/67Cu]Cu-NGUL for PSMA-targeted prostate cancer theranostics [0.03%]
铜-64/67铜-NGUL用于PSMA靶向前列腺癌诊疗的药代学研究与剂量学研究
Hye Yeon Seo,Minseok Suh,Nadeem Ahmed Lodhi et al.
Hye Yeon Seo et al.
Background: Prostate-specific membrane antigen (PSMA) is a promising target for imaging and theranostics in prostate cancer (PCa). Current PSMA tracers face limitations due to short half-lives and logistics. We developed ...
Targeted alpha therapy of ovarian cancer with 212Pb-labeled anti-PTK7 antibody: On-site 212Pb production and preclinical insights [0.03%]
用于卵巢癌治疗的212Pb标记抗PTK7抗体靶向α疗法：现场212Pb生产及前期研究发现
Yani Berckmans,Roxanne Wouters,Zeljka Raskovic-Lovre et al.
Yani Berckmans et al.
Background: Targeted alpha therapy (TAT) is recognized as a promising approach for eradicating tumor micro-metastases, owing to its high linear energy transfer. These micro-metastases are often associated with elevated re...
Illuminating radionuclide therapy response: Monitoring cancer cell and CAF survival in a direct 2D co-culture model [0.03%]
放射核素治疗反应的检测：直接二维共培养模型中癌细胞和CAF存活情况的监测
Circe D van der Heide,Roisin McMorrow,Felipe Gama-Franceschi et al.
Circe D van der Heide et al.
Background: Targeted radionuclide therapy (TRT) directed at fibroblast activation protein (FAP), highly expressed on cancer-associated fibroblasts (CAFs), is a promising approach for treating stroma-rich tumors such as pa...
Evaluation of an 211At-labeled RGD peptide in an orthotopic glioblastoma model by targeted alpha therapy [0.03%]
评价211At标记的RGD肽在原位胶质母细胞瘤模型中的靶向α治疗效应
Hiroaki Echigo,Masayuki Munekane,Takeshi Fuchigami et al.
Hiroaki Echigo et al.
Introduction: Glioblastoma, the most aggressive and malignant glioma type, remains challenging to treat, necessitating novel therapeutic strategies. Building on our previous development of an 211At-labeled RGD peptide, Ga...
Evaluation of astatine-211-labeled benzoate derivatives for improved in vivo stability [0.03%]
评估苯甲酸衍生物的砹-211标记以提高其体内稳定性
Mutsuho Murata,Kento Kannaka,Souta Tatsuta et al.
Mutsuho Murata et al.
Purpose: Astatine-211 (211At) is one of the most promising α-particle-emitting radionuclides used for targeted-alpha therapy. Benzene derivatives are currently commonly used as 211At-labeling moieties for preparing 211At...
Alternative production of Lead-203: Optimizing production, purification, and radiolabelling for enhanced theranostic applications [0.03%]
铅-203的替代生产：优化生产、纯化和放射性标记以增强诊疗应用
Nadia Audouin,Héloïse Dufour,Aurélien Vidal et al.
Nadia Audouin et al.
Introduction: this study investigates the production of Lead-203 (203Pb) using a deuteron beam and demonstrates its application with DOTATATE for diagnostic imaging of neuroendocrine tumours (NETs) thanks to its γ-ray em...