A new series of FAP inhibitors for cancer imaging based on 8-substituted (4-quinolinoyl)-glycyl-2-cyanopyrrolidine [0.03%]
一类基于8-取代（4-喹啉甲酰基）-甘氨酰-2-氰基吡咯啶的FAP抑制剂用于癌症显影
Hanyue Ma,Le Li,Amber Piet et al.
Hanyue Ma et al.
Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts across most epithelial tumors but FAP is nearly absent in normal tissues, making it an attractive target for cancer imaging and therapy. Small-molecule...
Carbonic anhydrase IX-targeted small molecule radiopharmaceuticals: A review of their role in clear cell renal cell carcinoma theranostics [0.03%]
以碳酐酶IX为靶点的小分子放射性药物在透明细胞肾细胞癌诊疗中的作用综述
Yuying Liu,Mengyi Zhang,Xinyue Ge et al.
Yuying Liu et al.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, representing 70-80% of cases. Its unique molecular profile and therapeutic resistance make it a key focus in oncology. Recent ad...
In vivo preclinical evaluation of YntraDose™ in pig's lung: A pilot study of a 90Y-microsphere device implantation [0.03%]
放射性钇[90Y]微球植入给药装置(YntraDose)的猪肺在体前临床试验小结
V Lanni,A Nocera,M L Vita et al.
V Lanni et al.
Background: YntraDose™ is a novel injectable radiotherapeutic formulation combining BioGlue® (bovine serum albumin-glutaraldehyde polymer) with Yttrium-90 resin microspheres. This pilot preclinical feasibility study rep...
Automated radiosynthesis of [64Cu]Cu-FAPI-2286 for FAP-targeted PET imaging [0.03%]
用于FAP靶向PET成像的[64Cu]Cu-FAPI-2286的自动化放射合成
Mohd Faheem,Vaibhav Pandey,Nidhi Singh Kushwaha et al.
Mohd Faheem et al.
Background: Fibroblast Activation Protein (FAP) is a critical target for imaging cancer-associated fibroblasts and active hepatic stellate cells in liver fibrosis. While FAPI-2286 has been widely explored with 68Ga and 17...
Electroless semi-automatic synthesis of 225Ac-labeled PSMA-derivatives for clinical application and evaluation of rechelation capability [0.03%]
用于临床应用的225Ac标记PSMA衍生物的半自动电镀合成及评价其再螯合能力
Marc Pretze,Petra Gehlmann,Florian Brandt et al.
Marc Pretze et al.
Introduction: Sustainable green radiochemistry is the result of current research, in which radiolabeling strategies are increasingly being developed in the direction of kit labeling. This includes the use of sunlight for ...
Preparation of electroplated zinc-68 targets for gallium-68 cyclotron production using recovered zinc-68 [0.03%]
回收锌-68制备电镀锌-68靶板用于镓-68回旋加速器生产
Ian M Horn,Mark S Jacobson,Carter J Jensen et al.
Ian M Horn et al.
Background: Gallium-68 (68Ga) is a PET isotope that is finding more use in the clinical setting as a PET diagnostic tool, for example 68Ga PSMA is widely used in the diagnosis of prostate cancer, and 68Ga dotatate for the...
Enhanced pre-therapy dosimetry for SSTR PET: A head-to-head preclinical assessment of [89Zr]Zr-DFO-TOC and [89Zr]Zr-DFO-TATE [0.03%]
SSTR PET预治疗剂量学增强：[89Zr]Zr-DFO-TOC和[89Zr]Zr-DFO-TATE的头对头前期评估
Alexis M Sanwick,Katherine N Haugh,Dustin R Osborne et al.
Alexis M Sanwick et al.
Neuroendocrine tumors (NETs) represent a clinically heterogeneous group of malignancies originating from neuroendocrine cells, with the potential to arise in nearly any organ system. Despite their relatively low incidence, NETS are associat...
Pharmacokinetics and dosimetry of radiolabeled FAP-targeting single-domain antibody 4AH29 in Göttingen minipigs [0.03%]
放射性标记FAP靶向单域抗体4AH29在小 Göttigen 猪体内的药代动力学和剂量学研究
Nina Dumauthioz,Laurent Navarro,Marion Berdal et al.
Nina Dumauthioz et al.
Background: Fibroblast activation protein alpha (FAP) is a pan-tumor target highly expressed on cancer-associated fibroblasts. We developed 4AH29, a single-domain antibody binding FAP, and investigated the biodistribution...
Comparative intra-articular retention of [177Lu]Lu-MAA and 90Y resin in a rat knee model [0.03%]
比较[177Lu]Lu-DOTMSA和90Y树脂在大鼠膝关节模型中的滑膜滞留率
Emre Karayel,Hüseyin Pehlivanoğlu,Aslan Aygün et al.
Emre Karayel et al.
Radiosynovectomy (RSV) relies on intra-articular administration of beta-emitting radiopharmaceuticals, where sufficient joint retention and minimal extra-articular leakage are critical determinants of therapeutic safety and efficacy. While ...