Profiling of metabolic alterations in mice infected with malaria parasites via high-resolution metabolomics [0.03%]
基于高分辨率代谢组学的疟原虫感染小鼠代谢重编程分析
Jyoti Chhibber-Goel,Anurag Shukla,Dhanasekaran Shanmugam et al.
Jyoti Chhibber-Goel et al.
Background: Malaria infection can result in distinct clinical outcomes from asymptomatic to severe. The association between patho-physiological changes and molecular changes in the host, and their correlation with severit...
Biophysical description of Bromosulfophthalein interaction with the 28-kDa glutathione transferase from Schistosoma japonicum [0.03%]
有关日本血吸虫28-kDa谷胱甘肽转移酶与溴磺酞的生物物理研究
Kagiso Pooe,Monare Thulo,Hattie Makumbe et al.
Kagiso Pooe et al.
Glutathione transferases (GSTs) are major detoxification enzymes vital for the survival and reproduction of schistosomes during infection in humans. Schistosoma encode two GST isoenzymes, the 26- and 28-kDa isoforms, that show different sub...
MicroRNA-181b promotes schistosomiasis-induced hepatic fibrosis by targeting Smad7 [0.03%]
microRNA-181b通过靶向Smad7促进肝纤维化病情发展
Shu Wang,Jianqiang Zhang,Hui Chen et al.
Shu Wang et al.
Schistosomiasis is a common parasitic disease. Hepatosplenic schistosomiasis, caused by Schistosoma japonicum and Schistosoma mansoni, involves pathological changes, including worm egg-induced hepatic granuloma and fibrosis, which can marke...
Louise E Atkinson,Elissa A Hallem
Louise E Atkinson
Synthesis, in vitro schistosomicidal activity and ultrastructural alterations caused by thiosemicarbazones and thiazolidinones against juvenile and adult Schistosoma mansoni worms (Sambon, 1907) [0.03%]
新型半卡巴唑衍生物对曼氏血吸虫的体内外活性及其作用机制研究
Rubens Emanoel Tavares da Rocha,Antônio Sérgio Alves de Almeida Júnior,Nairomberg Cavalcanti Portela Júnior et al.
Rubens Emanoel Tavares da Rocha et al.
Schistosomiasis is a neglected disease that affects about 258 million people worldwide. Caused by Schistosoma mansoni, helminth which, in Brazil, it is present on 19 states and capital. Praziquantel (PZQ) treatment presents low efficacy and...
Characterization of adjacent charged residues near the agonist binding site of the nematode UNC-49 GABA receptor [0.03%]
线虫UNC-49 GABA受体激动剂结合位点附近相邻带电残基的特征分析
Everett Cochrane,Joshua Foster,Mohammad Hassan Khatami et al.
Everett Cochrane et al.
The UNC-49 receptor is a Cys-loop GABA receptor that is unique to the nematode phylum. The receptor differs from mammalian GABA receptors both in amino acid sequence and pharmacology which highlights its potential as a novel anthelmintic ta...
Alpha-terthienyl increases filamentous actin of Entamoeba histolytica [0.03%]
α-三亚苯基增加溶组织内阿米巴的丝状肌动蛋白
Mayra Herrera-Martínez,Verónica Ivonne Hernández-Ramírez,Sarita Montaño et al.
Mayra Herrera-Martínez et al.
This study aimed to know if alpha terthienyl (α-T) affects E. histolytica viability and to analyze its effect on the actin cytoskeleton. Trophozoites of E. histolytica HM1-IMSS were treated with α-T, then, cell viability and morphology we...
Is Strongyloides stercoralis hyperinfection induced by glucocorticoids a result of both suppressed host immunity and altered parasite genetics? [0.03%]
糖皮质激素诱发的钩口线虫感染是否由宿主免疫抑制和寄生虫遗传改变引起？
De&#x;Broski R Herbert,Jonathan D C Stoltzfus,Heather L Rossi et al.
De&#x;Broski R Herbert et al.
The gastrointestinal (GI) nematode Strongyloides stercoralis (S.s.) causes human strongyloidiasis, a potentially life-threatening disease that currently affects over 600 million people globally. The uniquely pernicious aspect of S.s. infect...
Aminoacyl-tRNA synthetase (AARS) as an attractive drug target in neglected tropical trypanosomatid diseases-Leishmaniasis, Human African Trypanosomiasis and Chagas disease [0.03%]
氨酰-trna合成酶（aars）是被忽视的热带鞭毛寄生虫病-利什曼病，人类非洲锥虫病和恰加斯病的药物靶点
Vikas Kushwaha,Neena Capalash
Vikas Kushwaha
TriTryp diseases (Leishmaniasis, Human African Trypanosomiasis (HAT), and Chagas disease) are devastating parasitic neglected tropical diseases (NTDs) that affect billions of people in developing countries, cause high mortality in humans, a...
Strongyloides spp. eliminate male-determining sperm post-meiotically [0.03%]
Strongyloides 单细胞生物排除雄性决定精子后mezosity期结束时的精子
Alex Dulovic,Iris Koch,Katharina Hipp et al.
Alex Dulovic et al.
If normal male meiosis occurs, it would be expected that 50 % of sperm lack an X chromosome (nullo X) and hence upon fertilisation, result in male progeny. However, for sexual reproduction within the free-living stages of Strongyloides spp....