Characterization of adjacent charged residues near the agonist binding site of the nematode UNC-49 GABA receptor
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The UNC-49 receptor is a Cys-loop GABA receptor that is unique to the nematode phylum. The receptor differs from mammalian GABA receptors both in amino acid sequence and pharmacology which highlights its potential as a novel anthelmintic target. Sequence diffe... ...