Modular nanotheranostic agents for protistan parasitic diseases: Magic bullets with tracers [0.03%]
用于原生动物寄生虫病的模块化纳米诊疗剂：带有示踪物的神奇子弹
Sutherland Kester Maciver,Sumayah Abdelnasir,Ayaz Anwar et al.
Sutherland Kester Maciver et al.
Protistan parasitic infections contribute significantly to morbidity and mortality, causing more than 2 billion human infections annually. However, current treatments are often limited; due to ineffective drugs and drug resistance, thus bet...
Phylogeny and population structure of Echinococcus granulosus (sensu stricto) based on full-length cytb-nad2-atp6 mitochondrial genes - First report from Sialkot District of Pakistan [0.03%]
基于完整线粒体基因cytb-nad2-atp6序列的Echinococcus granulosus（狭义）的系统发育和群体结构分析-巴基斯坦Sialkot地区首报
Mughees Aizaz Alvi,Rana Muhammad Athar Ali,Li Li et al.
Mughees Aizaz Alvi et al.
Cystic echinococcosis is a zoonotic disease of livestock having serious economic setbacks. The etiological agents of the disease belong to Echinococcus granulosus sensu lato. Despite of worldwide distribution of the disease, the molecular s...
Characteristics of γδTCR on myeloid cells from C57BL/6 mice with Plasmodium yoelii nigeriensis infection [0.03%]
啮齿类疟原虫感染的C57BL/6小鼠髓系细胞γδ TCR的特点
Dianhui Chen,Feng Mo,Meiling Liu et al.
Dianhui Chen et al.
Recently, there is a paucity of studies focus on the characteristics of myeloid cells which expressed γδTCR. The aim of this study was to observe the properties of γδTCR-expressing myeloid cells in the spleen of C57BL/6 mice infected by...
Deficiency in TLR4 impairs regulatory B cells production induced by Schistosome soluble egg antigen [0.03%]
TLR4的缺乏影响由血吸虫可溶性虫卵抗原诱导的B调节细胞的产生
Fang Tian,Kangwen Xian,Bin Yang et al.
Fang Tian et al.
Regulatory B cells (Bregs) producing IL-10 have negative regulatory function. Several studies have shown the important roles for Toll-like receptor 2 (TLR2), TLR4, and TLR9 ligation in the development of Bregs. We have reported that Schisto...
Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives [0.03%]
吡喹酮：对血吸虫病作用机制的更新及新的治疗展望
Ranielly Araujo Nogueira,Maria Gabriela Sampaio Lira,Irlla Correia Lima Licá et al.
Ranielly Araujo Nogueira et al.
Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis, although its mechanisms of action are not completely understood. PZQ acts largely on adult worms. This narrative literature review describes what is...
Application of a low-cost, specific, and sensitive loop-mediated isothermal amplification (LAMP) assay to detect Plasmodium falciparum imported from Africa [0.03%]
用于检测从非洲输入的恶性疟原虫的低成本、特异性和敏感性的环介导等温扩增（LAMP）测定应用
Jiaqi Zhang,Xi Chen,Maohua Pan et al.
Jiaqi Zhang et al.
Background: Chinese citizens traveling abroad bring back imported malaria cases to China. Current malaria diagnostic tests, including microscopy and antigen-detecting rapid tests, cannot reliably detect low-density infect...
Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum [0.03%]
恶性疟原虫的谷氨酰tRNA合成酶(GluRS)的结构特性分析
Vivek Kumar Sharma,Jyoti Chhibber-Goel,Manickam Yogavel et al.
Vivek Kumar Sharma et al.
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes in protein translation machinery that provide the charged tRNAs needed for protein synthesis. Over the past decades, aaRSs have been studied as anti-parasitic, anti-bacterial, and ant...
Descriptive and functional analyses of four cyclin proteins in Trichomonas vaginalis [0.03%]
人阴道毛滴虫四种周期蛋白的描述和功能分析
Karla López-Pacheco,Roberto Hernández,Imelda López-Villaseñor
Karla López-Pacheco
Trichomonas vaginalis is an early divergent protozoan parasite that causes trichomoniasis, the most common non-viral sexually transmitted infection. In metazoans, there is abundant and detailed research on the cell cycle and the components ...
Construction of constitutive expression of Eimeria tenella eukaryotic initiation factor U6L5H2 on the surface of Lactobacillus plantarum and evaluation of its immunoprotective efficiency against chicken coccidiosis [0.03%]
鸡球虫病免疫保护效率的构建及评估
Lingyu Sun,Yaru Lu,Ningning Zhao et al.
Lingyu Sun et al.
Lactobacillus strains exhibit preferable properties that make them attractive candidates for vaccine delivery systems because of their ability to regulate intestinal mucosal immunity in the body. To date, live Lactobacillus delivery vaccine...
The Strongyloides bioassay toolbox: A unique opportunity to accelerate functional biology for nematode parasites [0.03%]
钩口线虫生物测定工具箱：加速丝状菌寄生虫功能生物学研究的独特机遇
Luke C Cadd,Bethany Crooks,Nikki J Marks et al.
Luke C Cadd et al.
Caenorhabditis elegans is a uniquely powerful tool to aid understanding of fundamental nematode biology. While C. elegans boasts an unrivalled array of functional genomics tools and phenotype bioassays the inherent differences between free-...