Drug delivery, development, and technological aspects for peripheral drug eluting stents [0.03%]
外周药物洗脱支架的递送、开发和技术方面的问题
Sarika A Jadhav,Ankur J Raval,Vandana B Patravale
Sarika A Jadhav
Drug-eluting stents are the standard therapy for arterial occlusions, particularly in peripheral arterial disease, owing to their efficacy in mitigating in-stent restenosis, maintaining favorable biocompatibility, and improving patient comp...
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications [0.03%]
基于适配体的靶向药物递送和疾病治疗在临床前和临床应用中的研究进展
Weihong Yang,Chunyan Ran,Xinran Lian et al.
Weihong Yang et al.
The advent of precision medicine has created an urgent need for advanced drug-targeting strategies and refined drug delivery systems. Aptamers, characterized by their exceptional affinity and specificity, low molecular weight, negligible im...
Multivalent engineering of bio interfaces with DNA-based nanomaterials [0.03%]
基于DNA的纳米材料在生物界面的多功能构建工程学研究进展
Shujie Li,Yameng Lou,Maartje M C Bastings
Shujie Li
In biology, function rarely depends on a single binding event. Whether it's cell signaling, immune recognition, or adhesion, most processes rely on a critical density of interactions that occur simultaneously and in close proximity. This mu...
Tanveer A Tabish,Craig A Lygate
Tanveer A Tabish
Nitric oxide (NO) is a powerful signalling molecule and plays a central role in numerous physiological processes, most notably, in the cardiovascular, immune and central nervous systems. While organic nitrates, exemplified by nitroglycerin,...
Challenges and opportunities on achieving an adequate delivery efficiency and immunogenicity with peptide-based anticancer vaccines [0.03%]
基于肽的抗癌疫苗实现足够递送效率和免疫原性的挑战与机遇
Yanqing Wang,Da Sun,Victoria Laney et al.
Yanqing Wang et al.
Peptide vaccines are based on small peptide segments that contain antigenic epitopes recognizable by immune cells. Unlike traditional vaccines, they include only specific antigenic epitopes rather than entire pathogens or proteins. They are...
DNA-based nanostructures for cell membrane receptor regulation and disease treatment [0.03%]
基于DNA的纳米结构在细胞膜受体调节和疾病治疗中的应用
Zhongyu Cheng,Yanfei Liu,Qiwen Chen et al.
Zhongyu Cheng et al.
The aberrant expression and dysfunction of cell membrane receptors are closely associated with the onset and progression of various major diseases, such as cancer, neurodegenerative disorders, and inflammation. However, conventional membran...
Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future [0.03%]
基因尺度代谢模型在抗菌药理学中的应用：现状与未来展望
Jianjun Tao,Yu-Wei Lin,Lingyuxiu Zhong et al.
Jianjun Tao et al.
The persistent surge in antimicrobial resistance (AMR) has propelled the search for innovative strategies in antimicrobial use. Genome-scale metabolic modelling (GSMM) has emerged as a transformative tool in this quest, offering a comprehen...
DNA nanotechnology in oligonucleotide drug delivery systems: prospects for bio-nanorobots in cancer treatment [0.03%]
基于DNA纳米技术的寡核苷酸药物递送系统及生物纳米机器人在癌症治疗中的应用展望
Haniyeh Abdollahzadeh,Tonya L Peeples,Mohammad Shahcheraghi
Haniyeh Abdollahzadeh
DNA-based nanomaterials have demonstrated significant potential in various applications due to their unique properties, including DNA's diverse molecular interactions, programmability, and versatility with biological modules. Meanwhile, the...
Patient-Derived 3D-Bioprinted models of pancreatic Cancer: Toward personalized therapy and overcoming tumor microenvironment challenges [0.03%]
基于患者的三维生物打印胰腺癌模型：个性化治疗及克服肿瘤微环境挑战的前景
Daniella Vaskovich-Koubi,Marina Green Buzhor,Anne Krinsky et al.
Daniella Vaskovich-Koubi et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and treatment-resistant solid tumors, mainly due to its complex tumor microenvironment (TME). Characterized by dense desmoplastic stroma, immune suppression, and metaboli...
Classic versus innovative strategies for immuno-therapy in pancreatic cancer [0.03%]
胰腺癌免疫治疗的常规策略与创新策略
Maria Giovanna Formelli,Andrea Palloni,Simona Tavolari et al.
Maria Giovanna Formelli et al.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis. Immunotherapy with immune checkpoint inhibitors (ICIs), either as monotherapy, in combination with other ICIs, or alongside chemotherapy, has signi...