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Patient-Derived 3D-Bioprinted models of pancreatic Cancer: Toward personalized therapy and overcoming tumor microenvironment challenges

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and treatment-resistant solid tumors, mainly due to its complex tumor microenvironment (TME). Characterized by dense desmoplastic stroma, immune suppression, and metabolic rewiring, the TME ... ...