A M van der Does,L V Schledorn,R Olmer
A M van der Does
Chronic lung diseases (CLD), including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis and pulmonary hypertension, represent a significant health burden worldwide and their incidence is steadily increasing. Specifically, CO...
Shaobo Yang,Mengdi Yang,Maria Jennings et al.
Shaobo Yang et al.
Bacteria have emerged as versatile platforms for therapeutic delivery, owing to their inherent adaptability, genetic tractability, and ability to interface with the human microbiome and immune system. This review explores the evolution of b...
Recent advances in gene delivery for melanocyte-associated disorders [0.03%]
近期基因传递在黑色素细胞相关疾病治疗中的新进展
Tanya Chhibber,Dekker C Deacon,Hamidreza Ghandehari et al.
Tanya Chhibber et al.
Melanocytes are cells present at the epidermal-dermal junction of the skin that produce pigment melanin, which provides color to the skin, eyes, and hair. Dysregulation in melanocyte function, viability, or differentiation can result in mel...
20 years of flash nanoprecipitation - from controlled precipitation to global medicine [0.03%]
闪纳米沉淀技术诞生二十周年——从可控沉淀到全球医药
Kurt D Ristroph,Nathalie M Pinkerton,Chester E Markwalter et al.
Kurt D Ristroph et al.
In the twenty years since the development of Flash NanoPrecipitation (FNP) technology, an antisolvent precipitation technique that uses rapid turbulent mixing to drive self-assembly of polymeric or lipid nanoparticles, the platform has been...
Glioblastoma and blood-brain barrier cell interplay in vitro models for stratification of drug efficacy [0.03%]
体外模型中胶质母细胞瘤与血脑屏障细胞的相互作用用于药物疗效分类
Cecília Ferreira,Bruno Sarmento,Cláudia Martins
Cecília Ferreira
Glioblastoma (GBM) is the most lethal brain cancer in adults, with a dismal prognosis and no curative therapies available. The treatment landscape remains largely stagnant, relying on tumor resection, temozolomide (TMZ) chemotherapy, and ra...
Optical technologies in monitoring mobility and delivery of drugs and metabolic agents [0.03%]
光学技术在监控药物及代谢载体输送方面的应用
Valery V Tuchin,Tianhong Dai,Luís M Oliveira
Valery V Tuchin
Yingying Li,Tatiana N Zamay,Natalia A Luzan et al.
Yingying Li et al.
Cancer treatment has transitioned from traditional chemotherapy to the molecular medicine era, emphasizing personalized therapy at the molecular level. Aptamers, also known as 'chemical antibodies', play a pivotal role in advancing molecula...
Stefana Duca,Sara Jamshidi Parvar,Luke Kumeta et al.
Stefana Duca et al.
Diffuse midline gliomas (DMGs) are a highly aggressive and inoperable type of paediatric brain tumours, with a median survival of less than one year. Therapeutic progress has been hindered by the tumour's anatomical location, its extensive ...
Toward pharmaceutical selective laser sintering 3D printing - a thermal and temperature-dependent analysis perspective [0.03%]
面向制药业的选择性激光烧结3D打印-热和温度依赖分析视角
Marta Łaszcz,Magdalena Urbanowicz,Ewelina Baran et al.
Marta Łaszcz et al.
The potential advantages of pharmaceutical additive manufacturing (AM) are thoroughly described in the literature. Challenges related to pharmaceutical AM are less discussed. Selective laser sintering (SLS) is one of the AM methods possible...
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies [0.03%]
胰腺导管腺癌的肿瘤微环境分型：个性化治疗策略的新途径
Dharini Srinivasan,Johann Gout,Alexander Kleger et al.
Dharini Srinivasan et al.
In the past decade, single-cell-resolved approaches have uncovered the extensive heterogeneity of pancreatic ductal adenocarcinoma (PDAC), reshaping our understanding of this complex solid tumor. PDAC entities exhibit both intra- and inter-...