From PEG to randomized PEG: a macromolecular strategy tackling PEG immunogenicity [0.03%]
从PEG到随机化PEG：一种应对聚乙二醇免疫原性的大分子策略
Julian Schmidt,Caroline Bockhard,Lea Simon et al.
Julian Schmidt et al.
PEGylation is a crucial strategy in modern nanomedicine, offering effective and safer therapeutics. However, the growing prevalence of anti-PEG antibodies (APAs) in patients has raised critical concerns, with multiple studies demonstrating ...
Redox-responsive nanomaterials for mRNA delivery: From rational design to therapeutic applications [0.03%]
用于mRNA递送的氧化还原响应型纳米材料：从理性设计到药物应用
Meng Li,Yifan Wang,Jing Gao et al.
Meng Li et al.
Messenger RNA (mRNA) therapeutics have emerged as a transformative biomedical platform with broad potential in vaccination, protein replacement, gene editing, and cancer immunotherapy. Despite substantial progress, the broader clinical tran...
Jens B Simonsen,Viktor T Lemgart,Jayesh A Kulkarni et al.
Jens B Simonsen et al.
In vivo reprogramming of T cells represents a transformative approach in immune-based therapies, with the potential to overcome the limitations of traditional ex vivo-engineered T cell products, such as autologous CAR-T therapies. While CAR...
Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling [0.03%]
针对神经退行性疾病的脑部给药：当前递送平台和建模的努力与挑战
Katherine Y Bang,Ross Walenga,Steven Chopski et al.
Katherine Y Bang et al.
Neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD), globally pose a significant challenge with an aging population. Despite the presence of various therapeutic agents, AD and PD treatments with small m...
Decoding cellular dynamics and microenvironmental responses in organ-on-chip systems through real-time sensing [0.03%]
基于实时传感的器官芯片系统中细胞动态及微环境响应解析
Pooja Gupta,Eshira Gupta,Ratnesh Jain et al.
Pooja Gupta et al.
Organ-on-Chip (OoC) systems hold extraordinary promise for predictive drug development and disease modeling. Yet their translational impact is constrained by several challenges, one of which is the inability to monitor cellular microenviron...
Redox-activated heavy-atom-free photosensitizers for enhanced photodynamic cancer therapy [0.03%]
非重金属光敏剂的氧化还原活化用于增强光动力治疗效果
Hyunsun Jeong,Haoyang Song,Van-Nghia Nguyen et al.
Hyunsun Jeong et al.
In recent years, heavy-atom-free photosensitizers have been recognized as an important class of agents for photodynamic therapy (PDT). In particular, redox-activated heavy-atom-free photosensitizers inspired by the redox imbalance of the tu...
Magda Swedrowska,Rebecca Fransson,Esther Jacobs et al.
Magda Swedrowska et al.
Proteolysis targeting chimeras (PROTACs) occupy a challenging oral developability space defined by high molecular weight, elevated polarity and lipophilicity, and substantial conformational flexibility, placing many candidates beyond conven...
You Zhou,Nan Lu,Muhammad Waqqas Hasan et al.
You Zhou et al.
Redox-responsive lipid nanoparticles (LNPs) are emerging as a powerful platform for precision nanomedicine by exploiting disease-associated redox imbalances, such as elevated glutathione and reactive oxygen species, to trigger controlled ca...
Silicone oil in protein drug products and its implications for formulation stability [0.03%]
蛋白质药物产品中的硅油及其对制剂稳定性的影响
Deepak Kumar Tripathi,Alexandra Lucas,Vaibhav Upadhyay et al.
Deepak Kumar Tripathi et al.
High-concentration biologics are transforming patient care by making potent injectable therapies easier and more accessible. But these biologics come with real stability hurdles. Proteins at these concentrations are more prone to clumping, ...
Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD) [0.03%]
靶向蛋白降解嵌合体(PROTAC)和分子胶脱ぐ剂(MGD)的递送
Mainak Banerjee,Alexandre Detappe,Twan Lammers
Mainak Banerjee
Targeted protein degraders (TPDs), including proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD), are among the most promising small-molecule-based drug treatments in oncology. The May 2026 U.S. Food and Drug Administ...