Understanding semantic impairments in schizophrenia from a predictive coding perspective [0.03%]
从预测编码的角度理解精神分裂症的语义障碍
Yukiko Matsumoto,Ryusuke Hayashi,Hidehiko Takahashi
Yukiko Matsumoto
Schizophrenia is characterized by profound semantic impairments that manifest as disrupted language and thought. We provide empirical support for the hypothesis that predictive coding forms a unifying framework for understanding these defic...
Graded regulation of microtubule-binding of Tau by the phosphorylation state of the proline-rich region in living neurons [0.03%]
活神经元中Tau脯氨酸丰富区域磷酸化状态调节微管结合的分级调控
Rinaho Nakata,Tomohiro Torii,Tomohiro Miyasaka et al.
Rinaho Nakata et al.
Tau protein is a microtubule-associated protein that plays a crucial role in maintaining neuronal morphology and axonal transport. While phosphorylation is known to regulate Tau-microtubule interactions, the contribution of specific phospho...
Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding [0.03%]
急性压力通过PVN激活抑制饥饿驱动的觅食行为：焦虑缓解药物和胃泌素受体激动剂逆转作用及其类似焦虑缓解的作用
Ryusei Tojo,Mayuka Tashiro,Haruka Takahashi et al.
Ryusei Tojo et al.
Feeding behavior is influenced by both metabolic drive and emotional context, yet how acute stress interferes with hunger-driven motivation remains poorly understood. Using a conflict-based open-field feeding paradigm, we examined how 30-mi...
Experimental Modeling for Tauopathies: An Isogenic Panel of Humanized MAPT Knock-in Mice [0.03%]
Tau病的实验建模：人MAPT敲入小鼠同源重组品系面板
Takahiro Morito,Naoto Watamura
Takahiro Morito
Tauopathies are a group of neurodegenerative diseases characterized by the aberrant accumulation of tau protein in the brain. While numerous mouse models have been developed to study tauopathies, the majority depend on tau overexpression, w...
A Mouse Model of Bilateral Acute Inner-ear (labyrinthine) Injury with Vestibular Involvement Reveals Functional, Behavioral, and Histological Correlates of Vestibular Compensation [0.03%]
一种涉及前庭功能的双侧急性内耳损伤小鼠模型揭示了前庭代偿的功能、行为和组织学相关性
Jingyi Xie,Xiaotong Zhang,Shengli Li et al.
Jingyi Xie et al.
Bilateral vestibular dysfunction disrupts balance and spatial orientation, yet mechanisms of injury and compensation remain incompletely defined. We established a mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibula...
Fluoxetine enhances the treatment of depression linked to opioid-induced constipation in mice by influencing the metabolomic profile [0.03%]
氟西汀通过影响代谢组学谱型增强吗啡致肠梗阻小鼠抑郁的治疗效果
Chun Wang,Shiqin Yao,Bowen Tian et al.
Chun Wang et al.
This study was intended to verify the potential role of Fluoxetine (Flx) in treating depression associated with opioid-induced constipation (OIC). We established a mouse model of chronic unpredictable mild stress (CUMS) and used loperamide ...
Daisuke Joho,Kenya Sato,Wakako Kumita et al.
Daisuke Joho et al.
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. It is characterized by cognitive decline and brain pathology, including amyloid-β (Aβ) plaques, neurofibrillary tangles, and neuroinflammation. While roden...
Drug discovery research with the iPSC models of neurodegenerative diseases [0.03%]
基于神经退行性疾病的诱导多能干细胞模型的药物发现研究
Masahiro Adachi,Haruhiko Banno,Haruhisa Inoue
Masahiro Adachi
Induced pluripotent stem cells (iPSCs) are widely used in research because they can be used to create models of diseases with the same genomic background as in patients. Recently, it has become recognized that the use of iPSCs for screening...
iPSC-derived neural organoids in dementia research: recent advances and future directions [0.03%]
基于 iPSC 的神经器官体在痴呆研究中的最新进展和未来方向
Shogo Shima,Takayuki Kondo,Haruhisa Inoue
Shogo Shima
Neural organoids are self-assembled three-dimensionally shaped aggregates generated from pluripotent stem cells for the purpose of generating brain-like structures. Organoids derived from patient induced pluripotent stem cells (iPSCs) can r...
Traumatic brain injury and Alzheimer's disease related neurodegenerative diseases: Insights from animal models [0.03%]
取自动物模型的创伤性脑损伤和阿尔茨海默病相关神经退行性疾病的研究见解
Xinyi Zhao,Zhuohao He
Xinyi Zhao
Alzheimer's disease and related neurodegenerative diseases (ADRD) represent a major global public health challenge, with their disease mechanisms remain largely unknown, and few treatments are available. Increasing epidemiological evidence ...