Fluoxetine enhances the treatment of depression linked to opioid-induced constipation in mice by influencing the metabolomic profile
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This study was intended to verify the potential role of Fluoxetine (Flx) in treating depression associated with opioid-induced constipation (OIC). We established a mouse model of chronic unpredictable mild stress (CUMS) and used loperamide to induce constipati... ...
