Cooperative role of CD81 with GPR56 and collagen III in cortical formation [0.03%]
CD81与GPR56和III型胶原蛋白在皮层形成中的协同作用
Yu-Jin Jang,Jung Yoon Heo,Hyeryun Shin et al.
Yu-Jin Jang et al.
The ADGRG1 gene encodes GPR56, an adhesion G-protein-coupled receptor essential for neuronal migration during cortical development. GPR56 interacts with extracellular matrix components such as collagen III, integrin α3β1, and tetraspanins...
Neuroscience Research Special Issue Toward a unified theory of prediction and action [0.03%]
预测与行动的统一理论及其对神经科学研究的意义
Takuya Isomura
Takuya Isomura
In Vivo Two-Photon Imaging Reveals Stochastic and Synchronized Extracellular Signal-Regulated Kinase Dynamics in Neurons of Awake Mice [0.03%]
活体在体双光子显微成像揭示了清醒小鼠神经元中细胞外信号调节激酶动力学的随机性和同步性
Ceylin Zeybek,Yohei Kondo,Michiyuki Matsuda et al.
Ceylin Zeybek et al.
The neocortex is essential for higher-order brain functions such as cognition, perception, language, and motor control. Although extracellular signal-regulated kinase (ERK) activity in neurons has been well studied for its role in memory fo...
Triple equivalence in modelling insight and creativity: classical and quantum perspectives [0.03%]
三重等价性在建模洞察力和创造力方面的经典与量子视角
Takuya Isomura
Takuya Isomura
Understanding the emergence of novel ideas in the brain-which is a hallmark of insight and creativity-remains a fundamental challenge in neuroscience. While traditional frameworks such as predictive coding, the Bayesian brain hypothesis, an...
Real-time classification of cortical slow-wave states by a machine learning model [0.03%]
机器学习模型实时分类皮质慢波状态
Minato Uemura,Hiroyuki Mizuno,Yuji Ikegaya et al.
Minato Uemura et al.
During slow-wave sleep, cortical slow oscillations-composed of alternating Up/Down states (UDS)-are crucial for memory consolidation. We classified UDS from local field potentials using machine learning models, specifically a hybrid CNN + R...
A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction [0.03%]
一种新型脑干靶向G51Dα-突触核蛋白纤维注射小鼠模型出现睡眠和运动功能障碍的顺序性发展现象
Shinnosuke Yasugaki,Ami Kaneko,Hibiki Okamura et al.
Shinnosuke Yasugaki et al.
Abnormal accumulation of alpha-synuclein (α-syn) is a central pathologic hallmark of synucleinopathies such as Parkinson's disease (PD), with rapid eye movement sleep behavior disorder (RBD) widely recognized as a prodromal manifestation o...
Hippocampal myelin damage contributes to cognitive impairment in a rat model of trigeminal neuropathic pain: neuroprotective and anti-inflammatory effects of atorvastatin [0.03%]
他汀类药物对三叉神经病理性痛大鼠模型海马区白质损伤的保护作用及机制研究
Yongkui Yang,Youzhi Ning,Shuangchun Peng et al.
Yongkui Yang et al.
Chronic neuropathic pain is increasingly recognized to impair cognitive function, yet its underlying mechanisms remain unclear. This study tested whether trigeminal neuropathic pain (TNP) modeled by distal infraorbital nerve chronic constri...
Gradual proactive regulation of body state by reinforcement learning of homeostasis [0.03%]
稳态的强化学习逐步主动调节机体状态
Mana Fujiwara,Honda Naoki
Mana Fujiwara
Living systems maintain physiological variables such as temperature, blood pressure, and glucose within narrow ranges-a process known as homeostasis. Homeostasis involves not only reactive feedback but also anticipatory adjustments shaped b...
Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection [0.03%]
阿托品治疗不能改善沙林气中毒小鼠的认知功能但可使其脑电图恢复正常
Mélanie Lagadec,Pauline Thiebot,Isabelle Malissin et al.
Mélanie Lagadec et al.
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis. The current antidote therapy in...
High-resolution optogenetics generates distinguishable neocortical activity patterns in awake mice [0.03%]
高分辨率光遗传学在清醒小鼠中产生可区分的新皮层活动模式
Ryosuke Yoshida,Yamato Ishii,Kotaro Yamashiro et al.
Ryosuke Yoshida et al.
The neural basis of cognition is rooted in precisely coordinated population activity unfolding on the millisecond timescale. To causally probe these spatiotemporally intricate network dynamics, we developed a digital micromirror device (DMD...