Astrocyte engineering [0.03%]
星形胶质细胞工程学
Minami Motoyoshi,Jun Nagai
Minami Motoyoshi
Tiling across the central nervous system, astrocytes contact synapses, blood vessels and other glial cells through highly specialised processes, allowing them to regulate local brain environments across multiple spatial and temporal scales....
KLF4 is associated with perioperative neurocognitive disorder and SMAD7-linked oxidative stress and ferroptosis-related signaling [0.03%]
KLF4与围手术期神经认知障碍及SMAD7相关的氧化应激和铁死亡相关信号通路有关
Zilong Huang,Xuewu Lin
Zilong Huang
Perioperative neurocognitive disorder (PND) is a common complication after anesthesia and surgery, particularly in older individuals, and is associated with oxidative stress and ferroptosis. Krüppel-like factor 4 (KLF4) has been implicated...
KLF4 is associated with perioperative neurocognitive disorder and SMAD7-linked oxidative stress and ferroptosis-related signaling [0.03%]
KLF4与围手术期神经认知障碍及SMAD7相关的氧化应激和铁死亡相关信号通路有关
Zilong Huang,Xuewu Lin
Zilong Huang
Perioperative neurocognitive disorder (PND) is a common complication after anesthesia and surgery, particularly in older individuals, and is associated with oxidative stress and ferroptosis. Krüppel-like factor 4 (KLF4) has been implicated...
Bidirectional interactions between temperature and microglia: Implications for brain function and disease [0.03%]
温度和小胶质细胞之间的双向相互作用：对脑功能和疾病的意义
Rena Kono,Ryuta Koyama
Rena Kono
Temperature profoundly influences brain physiology and pathology. Accumulating evidence indicates that microglia, the resident immune cells of the central nervous system, are highly sensitive to temperature changes. Experimental evidence in...
Orthodontic force alters Piezo/TRP channel expression in trigeminal ganglion and trigeminal mesencephalic nucleus neurons innervating the periodontal ligament [0.03%]
正畸力改变牙周膜三叉神经脊核和三叉神经节神经元Piezo/TRP通道的表达
Kiyoaki Tagami,Takehito Ouchi,Maki Kimura et al.
Kiyoaki Tagami et al.
Mechanical stimulation to periodontal ligament (PDL) by orthodontic force is received by the peripheral mechanoreceptors of trigeminal ganglion (TG) neurons and/or trigeminal mesencephalic nucleus (MesV) neurons, which are the primary senso...
Nonlinear Associations Between Sleep Duration and Dementia: Evidence from the CHARLS and Mendelian Randomization Analysis [0.03%]
睡眠时长与痴呆症之间非线性关系的研究：中国健康与退休纵向研究及孟德尔随机化分析的证据
Xiaoqing Tao,Shan Wang,Li He et al.
Xiaoqing Tao et al.
Dementia poses a substantial global health burden, necessitating public health focus on modifiable risk factors. While sleep duration has been linked to dementia risk, studies specifically addressing middle-aged and older Chinese adults rem...
Convolutional neural networks decode visual stimulus positions from local field potentials on the mouse cortex [0.03%]
卷积神经网络从鼠标皮层局部场电位中解码视觉刺激位置
Shotaro Yamada,Naofumi Suematsu,Hiroyuki Ito
Shotaro Yamada
Decoding visual information based on machine learning has the potential to reveal the neural mechanisms of visual information processing in the brain. Although most highly precise decoding methods require highly invasive electrodes, these e...
Cellular and molecular networks governing myelination dynamics in the central nervous system [0.03%]
调控中枢神经系统髓鞘动态的细胞和分子网络
Yong Wang,Manyue Ge,Ting Li et al.
Yong Wang et al.
Myelin, a multilamellar membrane structure enwrapping axons, is essential for rapid saltatory conduction, metabolic support, and long-term axonal integrity in the central nervous system (CNS). Myelination by oligodendrocytes (OLs) constitut...
Endogenous βⅢ-Tubulin FRAP Reveals microtubule dynamics in living developing neurons [0.03%]
内源性βⅢ-微管蛋白的FRAP实验揭示活体发育神经元中微管动态特性
Yuri Sakai,Yuki Ogawa,Hiroaki Misonou
Yuri Sakai
Microtubules support neuronal morphology, intracellular transport, and neurite growth, but how microtubule turnover is regulated across neuronal compartments remains incompletely understood. To examine microtubule dynamics under physiologic...
Cellular basis of medium flow-mediated reduction of Aβ neurotoxicity in cultured neurons [0.03%]
中等程度流体 shear 流动通过细胞外机制降低淀粉样蛋白的神经毒性
Yoshiki Yagi,Sora Oda,Hitoshi Tatsumi
Yoshiki Yagi
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by elevated concentrations of amyloid β1-42 (Aβ1-42) in the brain, where it exerts neurotoxic effects. A recent study demonstrated that medium flow at approximately 10...