An anterior-posterior gradient in hippocampal subfield volumes linking sleep health to cognition in young adults [0.03%]
年轻人的睡眠健康与认知能力之间的海马亚区体积的前后梯度关系
Tianfang Han,Tongfang Ding,Shubing Li et al.
Tianfang Han et al.
Sleep has been robustly linked to hippocampal integrity and is considered important for cognitive function. However, it remains unclear how variations in sleep are associated with the structurally heterogeneous subfields of the hippocampus ...
The TDP-43I383V heterozygous mutation results in increased TDP-43 expression and altered neuronal activity in ALS patient-derived iPSC motor neurons [0.03%]
TDP-43I383V杂合突变导致ALS患者诱导多能干细胞运动神经元中TDP-43表达增加及神经元活性改变
Ryo Chikuchi,Yuta Kato,Aya Tomatsu et al.
Ryo Chikuchi et al.
TAR-binding protein 43 (TDP-43) is a pathogenic RNA-binding protein associated with amyotrophic lateral sclerosis (ALS). To elucidate the pathogenesis of ALS, we generated induced pluripotent stem cells (iPSCs) from lymphoblastoid cell line...
A computational model of canonical cortical microcircuits for dynamic Bayesian inference and control as inference [0.03%]
用于动态贝叶斯推理和控制的皮层微环路计算模型
Naohiro Yamauchi,Yoshimasa Tawatsuji,Yudai Suzuki et al.
Naohiro Yamauchi et al.
Canonical cortical microcircuits (CCMs), a six-layer architecture conserved across the mammalian neocortex, play a crucial role in cognitive functions such as sensory inference, decision-making, and motor planning. However, the computationa...
Performance evaluation of the earphone-type electroencephalogram for alpha wave detection [0.03%]
耳机型脑电图α波检测性能评估
Mao Otake,Takuya Ibaraki,Ming Chang et al.
Mao Otake et al.
Electroencephalography (EEG) is useful for monitoring brain functions. Recently, wearable earphone-type EEG devices that can be easily used at home have emerged. Although their application scope is expanding, their comfort and detection val...
Neuroscience Research: Special issue Parental Brain: The Neural Circuit Mechanisms in Mammals [0.03%]
神经科学研究：专题：父母之脑：哺乳动物中的神经回路机制
Kumi O Kuroda,Kazunari Miyamichi
Kumi O Kuroda
The neurobiology of human sequential signal prediction: Insights from language, music, and mathematics [0.03%]
人类序列信号预测的神经生物学：来自语言、音乐和数学的启示
Tomoya Nakai,Tatsuya Daikoku,Yohei Oseki
Tomoya Nakai
Humans use various sequential signals, such as language, music, and mathematics, to convey complex information and facilitate communication. Previous research has identified two fundamental frameworks underlying human sequential signal proc...
Comprehensive DNA methylation analysis of brain and peripheral tissues following chronic risperidone treatment in common marmosets [0.03%]
慢性利培酮治疗后狨猴脑和外周组织的全面DNA甲基化分析
Yui Murata,Ayaka Fujii,Yutaka Nakachi et al.
Yui Murata et al.
Antipsychotic drugs are increasingly recognized to exert therapeutic effects not only through neurotransmitter modulation but also, in part, through epigenetic mechanisms. Risperidone is an atypical antipsychotic drug widely used to treat s...
The Application of Directly Induced Neurons into Neurodegenerative Disease Modeling [0.03%]
直接诱导神经元在神经退行性疾病建模中的应用
Keita Matsumoto,Sumihiro Maeda
Keita Matsumoto
The advent of directly induced neurons (iNs) from human somatic cells has revolutionized disease modeling in neurodegeneration. This approach bypasses pluripotent stage during the neuronal cell inducing steps and preserves donor age-related...
Sodbileg Odonchimed,Keiko Imamura,Haruhisa Inoue
Sodbileg Odonchimed
Neurodegenerative diseases are characterized by the gradual deterioration of specific neuronal populations, ultimately resulting in motor, cognitive, or behavioral impairments. Despite the worldwide increase in disease incidence, effective ...
Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice [0.03%]
脑内出血后小胶质细胞M1型极化的新机制：脂连蛋白-2抑制Nrf2信号通路参与铁死亡诱导炎症反应
Tengfei Zhang,Chunhui Wang,Ying Li et al.
Tengfei Zhang et al.
Microglia and macrophages (M/M) play significant roles in intracerebral hemorrhage (ICH) injury, but the underlying mechanism is complicated and remains largely unknown. Lipocalin-2 (LCN2) expression elevates in M/M after ICH, yet its role ...