Dextromethorphan Is a Novel Pharmacological Inhibitor of F1FO-ATPase That Targets the Membrane-Embedded Domain Impairing ATP Synthesis and Hydrolysis [0.03%]
右美沙芬是一种新型的F1FO-ATP酶药理抑制剂，可针对膜整合结构域抑制ATP合成和水解
Cristina Algieri,Antonia Cugliari,Silvia Granata et al.
Cristina Algieri et al.
Dextromethorphan (DXM), a widely used antitussive agent, was investigated for its effects on mitochondrial F1FO-ATPase activity and oxidative phosphorylation. Our results demonstrate that DXM inhibited F1FO-ATPase independently of the thiol...
HSP27 Promotes Cutaneous Squamous Cell Carcinoma Progression by Inhibiting Ferroptosis [0.03%]
HSP27通过抑制铁死亡促进皮肤鳞状细胞癌进展
Yu-Xin Jiang,Jing Xu,Zi-Yue Wang et al.
Yu-Xin Jiang et al.
Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor originating from epidermal keratinocytes. In various types of tumors, ferroptosis is a vital iron-dependent form of regulated cell death. Recent studies suggest that heat shock p...
BACE1: Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders [0.03%]
人β淀粉样蛋白前体蛋白裂解酶1（BACE1）的生物学功能及其在阿尔茨海默病及其他神经系统疾病病理生理中的作用
Marija Bartolić,Anita Bosak
Marija Bartolić
β-Secretase (BACE1) is the key enzyme responsible for generating amyloid-β (Aβ) peptides, whose aggregation and plaque formation are major hallmarks of Alzheimer's disease (AD). Owing to its central role in Aβ production, BACE1 has beco...
Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro-Tumor Properties to Adipocytes by Stimulating Lipolysis [0.03%]
前列腺癌细胞释放的细胞外囊泡通过刺激脂解作用赋予脂肪细胞促肿瘤特性
Gaia Giannitti,Kinga Kamińska,Sara Marchesi et al.
Gaia Giannitti et al.
There is consistent evidence of an association between obesity and the risk of prostate cancer (PCa). A crosstalk between PCa and adipocytes has been highlighted; however, the role of extracellular vesicles (EVs) in this communication still...
Lactobacillus johnsonii JNU3402 Ameliorates Age-Related Liver Dysfunction Through Stimulating PGC-1α-Mediated SIRT1 Expression [0.03%]
乳酸菌johnsonii JNU3402通过刺激PGC-1α介导的SIRT1表达来改善年龄相关的肝功能障碍
Eunjeong Hong,Garam Yang,Sejong Oh et al.
Eunjeong Hong et al.
Lactobacillus johnsonii JNU3402 (LJ3402) has previously been reported to ameliorate diet-induced hepatic steatosis. Because aging is tightly linked to metabolic disease, we hypothesized that LJ3402 might protect against age-related metaboli...
Artificial Intelligence for Detection of Parkinson's Disease From Speech Signals-A Comprehensive Review [0.03%]
基于语音信号的帕金森病人工智能检测研究综述
Dipdisha Bose,Anirban Mukherjee,Mrinal Acharya et al.
Dipdisha Bose et al.
After Alzheimer's disease, Parkinson's disease (PD) is the second most common neuropathological condition. It is a progressive degenerative disease at superannuation that affects the central nervous system (CNS) and slowly disable patients ...
Hydroethanolic Soy Extract Rich in Isoflavones Protects Dystrophic Mutant Mice From Oxidative Stress and Inflammation via the ROS/NF-κB Feedback Pathway [0.03%]
异黄酮丰富的豆类提取物通过ROS / NF-κB反馈途径保护营养不良突变小鼠免受氧化应激和炎症的影响
Beatriz Godinho Nascimento,Laís Leite Ferreira,Wagner Corsini et al.
Beatriz Godinho Nascimento et al.
Soy isoflavones have been extensively studied for their beneficial effects in various diseases. Oxidative stress induces inflammation and myonecrosis in early disease stages in both mdx mice and human patients with Duchenne muscular dystrop...
Cepharanthine as a Biofactor: Molecular Functions, Signaling Pathway Modulation and Therapeutic Relevance in Cancer and Drug Resistance [0.03%]
喜 subtandine 的生物学功能：分子作用机制、信号通路调控及在肿瘤和耐药中的治疗意义
Hector Hernández Parra,Héctor Adrián García-Gasca,Sheila Iraís Peña-Corona et al.
Hector Hernández Parra et al.
Natural products are one of the pillars of the drug discovery process, as they provide various scaffolds and diverse biological activity. Cepharanthine (CEP), an alkaloid with a bisbenzyl-isoquinoline skeleton, was isolated from the Stephan...