Angiotensin II Promotes the Phenotypic Transition of c-Kit+ Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2 [0.03%]
血管紧张素II通过胶原受体盘状结构域受体2促进c-Kit+心脏间质细胞向肌成纤维细胞表型转换
Indraja Devidasan,Sruthi Radhakrishnan,Sarayu Gopal et al.
Indraja Devidasan et al.
Angiotensin II (Ang II), a potent profibrotic stimulus, exhibits pleiotropic effects on cardiac cells. The fate of c-Kit+ cells in an Ang II-elevated injured myocardium remains poorly defined. This study investigated, in vitro, the effect o...
Effects of a Commercial Standardized Green Rooibos (Aspalathus linearis) Extract on Caenorhabditis elegans and Zebrafish Anxiety-Like Behavior [0.03%]
商业化标准的绿色红茶叶（山桃叶）提取物对秀丽隐杆线虫和斑马鱼焦虑样行为的影响
David G Valcarce,Sonia Guilera,Ferran Balaguer et al.
David G Valcarce et al.
Anxiety-related disorders are among the most prevalent mental health conditions worldwide, driving interest in novel, plant-based interventions. This study aimed to evaluate the antioxidant activity and capacity to alleviate anxiety-like be...
Nelly M Silva,Ana S Martins,Nina E Karguth et al.
Nelly M Silva et al.
Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the geographical expansion of Aedes spp. mosquitoes. These arthropods are now found even in temperate climates, including Europe, where outbreaks have ...
VGLL3 Regulates DAPK2-Mediated Autophagy During Osteoblast Differentiation [0.03%]
VGLL3调节成骨细胞分化过程中DAPK2介导的自噬作用
Yuhan He,Ziyi Wang,Yao Weng et al.
Yuhan He et al.
Vestigial-like family member 3 (VGLL3), a transcriptional cofactor of the TEA domain family, has been previously identified as a regulator of osteoblast differentiation. Building upon our previous findings, we investigated VGLL3 function in...
Mechanism of YTHDF2-Mediated Epigenetic Modification in the Proliferation and Invasion of Renal Cell Carcinoma Cells [0.03%]
YTHDF2介导的表观遗传修饰在肾细胞癌增殖侵袭中的机制研究
Xiaomeng Zhang,Yan Zhang,Xin Yang et al.
Xiaomeng Zhang et al.
Renal cell carcinoma (RCC) ranks as the most prevalent form of urogenital cancer. This research aims to investigate the role of YTHDF2 in the RCC progression and identify new therapeutic targets for RCC. YTHDF2, E2F2, and CORO6 were assayed...
ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2 [0.03%]
ISG15通过直接靶向PIK3R2调节T2DM患者的氧化应激反应
Mei-Qi He,Jie Liu,Gao-Peng Guan et al.
Mei-Qi He et al.
Type 2 diabetes (T2DM), a chronic metabolic disorder characterized by pancreatic β-cell dysfunction and insulin resistance, is closely associated with oxidative stress. Interferon-stimulated gene 15 (ISG15), a ubiquitin-like modifier, has ...
Phytoestrogenic Isoflavone Formononetin Attenuates Motor Deficits and Mitochondrial Impairment by Regulating SIRT1/PGC-1α/NRF1/TFAM Axis in Parkinson's Disease [0.03%]
植物雌激素异黄酮formononetin通过调节SIRT1/PGC-1α/NRF1/TFAM轴减轻帕金森病运动缺陷和线粒体功能障碍
Jasleen Kaur,Saba Naqvi
Jasleen Kaur
Parkinson's disease (PD) is a progressive neurodegenerative disorder. An essential early hallmark of PD is disrupted mitochondrial dynamics driven by impaired cellular energy homeostasis. Therapeutic interventions restoring mitochondrial fu...
Molecular Extremes of Ovarian Response: Divergent PI3K/AKT/mTOR Signaling and Oxidative Stress Patterns in Low and High Responders Undergoing In Vitro Fertilization [0.03%]
卵巢反应的分子特征：体外受精患者中低反应组和高反应组PI3K/Akt/mTOR信号通路及氧化应激模式差异性研究
Oya Korkmaz,Seda Karabulut,Pelin Macit et al.
Oya Korkmaz et al.
Ovarian response extremes are associated with distinct alterations in the follicular microenvironment, yet the underlying molecular mechanisms remain incompletely understood. This study investigated oxidative stress, antioxidant responses, ...
Hydroxy-Safflower Yellow A Inhibits Breast Cancer Growth via Tumor-Associated Macrophages/CCL5/Tissue Resident Memory T Cell Signaling [0.03%]
羟基番红黄素A通过肿瘤相关巨噬细胞/CCL5/组织驻留记忆T细胞信号抑制乳腺癌生长
Le Zhou,Guowei Lai,Bo Han et al.
Le Zhou et al.
Hydroxy-safflor yellow A (HSYA), a bioactive compound from Carthamus tinctorius, has reported anti-inflammatory and antitumor activities. However, its effects on breast cancer and the underlying immune mechanisms remain poorly defined. In t...
Fermented Cabbage Brine as a Functional Dietary Modulator of Neuroinflammation, Oxidative Stress, and Anxiety-Like Behavior in Lipopolysaccharide-Challenged Mice [0.03%]
发酵泡菜汁通过调节神经炎症和氧化应激缓解脂多糖攻击小鼠的焦虑样行为
Vukojevic Andjela,Prvulovic Milica,Simeunovic Valentina et al.
Vukojevic Andjela et al.
Fermented foods are increasingly recognized for their health-promoting properties, but little is known about the effects of sauerkraut brine (SB), a by-product of cabbage fermentation, on systemic inflammation and neuro-inflammatory respons...