Zichen Liu,Wenshuai Deng,Zuoxiang Dong et al.
Zichen Liu et al.
Glioblastoma is lethal brain tumor with dismal prognosis. ETV1, an ETS family transcription factor, has been implicated in multiple malignancies, yet its precise role and regulatory mechanisms in glioma progression remain incompletely defin...
ANXA5: A Multi-Omics-Derived, UPR-Associated Dual-Function Biomarker for Prognosis and Immunotherapy Response Prediction in Glioma [0.03%]
Jiachong Wang,Haijun Guo,Wei Zheng et al.
Jiachong Wang et al.
Glioma, a highly aggressive brain cancer, thrives in an immunosuppressive tumor microenvironment (TME). The Unfolded Protein Response (UPR) is a key adaptive stress pathway implicated in therapy resistance. To discover clinically actionable...
Elesclomol Promotes oxLDL-Mediated Foam Cell Formation and Cuproptosis in Macrophages [0.03%]
Elesclomol促进巨噬细胞中oxLDL介导的泡沫细胞形成和铜死亡
Daming Jiang,Yigong Zhang
Daming Jiang
The formation of macrophage-derived foam cells is a critical factor in the development of atherosclerotic lesions. However, the mechanisms through which the cuproptosis pathway contributes to macrophage foam cell formation remain unclear. T...
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O-GlcNAcylation [0.03%]
辅酶Q10通过调节HDAC4的O-连接的N-乙酰葡萄糖胺化修饰缓解心肌梗死的作用机制研究
Wei Xie,Xiang Gao,Shifei Song et al.
Wei Xie et al.
Myocardial infarction (MI) is a major cause of mortality. This study explores the cardioprotective effects of Coenzyme Q10 (CoQ10) and its molecular mechanisms in MI. A rat myocardial ischemia-reperfusion model was established, and infarct ...
ANO6 Confers Paclitaxel Resistance by Targeting Ferroptosis in Cervical Cancer [0.03%]
ANO6通过靶向铁死亡介导宫颈癌帕利珠单抗耐药性
Yanming Cao,Yuping Peng,Jian Shen
Yanming Cao
Paclitaxel (PTX) resistance limits cervical cancer therapy. Ferroptosis suppression via GPX4 and redox remodeling has emerged as a resistance mechanism, but upstream regulators remain unclear. To determine whether ANO6 drives PTX resistance...
Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid-β: Integrated Biochemical and Computational Analysis [0.03%]
天然抗氧化剂调节淀粉样蛋白-β暴露诱导的嗅鞘细胞组织transglutaminase水平变化：生化与计算分析整合研究
Rosalia Pellitteri,Cristina Tomasella,Maria Assunta Chiacchio et al.
Rosalia Pellitteri et al.
Herein, we adopted a dual approach combining molecular modeling and biological studies, in order to assess the interaction between four selected natural antioxidants (NAs; berberine, curcumin, astaxanthin, indicaxanthin) and tissue transglu...
GRHL2/SENP1/VDR Signaling Axis: A Key Regulator of SUMOylation and Calcitriol Resistance in SHPT [0.03%]
GRHL2/SENP1/VDR信号轴在SHPT去SUMO化和骨化三醇抵抗中的关键作用
Yucan Miao,Ying Ding,Han Su et al.
Yucan Miao et al.
Accumulating evidence suggests that SUMOylation plays a crucial role in the progression and resistance of secondary hyperparathyroidism (SHPT). However, the precise mechanism of SUMOylation in SHPT remains unclear. We identified the potenti...
Impact of Cellular Senescence on LCN2 Expression in Salivary Gland Epithelial Cells and Oral Keratinocytes [0.03%]
细胞衰老对唾液腺上皮细胞和口腔角质形成细胞LCN2表达的影响
Yosuke Shikama,Kayo Yoshida,Yuka Shikama
Yosuke Shikama
Senescent cells are characterized by the up-regulation of senescence markers and exhibit key features, such as irreversible growth arrest and the senescence-associated secretory phenotype (SASP), which is mainly regulated by transcription f...
Shuhan Zhang,Jiaqi Chai,Wenjuan Zhang et al.
Shuhan Zhang et al.
Pancreatic cancer (PC) remains a highly lethal malignancy with limited treatment options, largely due to its heterogeneity and therapy resistance. While ferroptosis-a form of iron-dependent cell death driven by lipid peroxidation-has emerge...
Oral Administration of Crocus sativus Tepals Extract Restores High-Fat Diet-Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid Metabolism [0.03%]
藏红花冠恢复高脂饮食诱导的肠道菌群失调并调节肠道炎症和肝脏脂质代谢
Biljana Bursać,Miloš Vratarić,Ljupka Gligorovska et al.
Biljana Bursać et al.
Metabolic diseases have increased worldwide in recent decades, mainly due to a sedentary lifestyle and an unhealthy diet, with diet identified as an important regulator of gut microbiota composition. The use of natural products, such as Cro...