Dextromethorphan Is a Novel Pharmacological Inhibitor of F1FO-ATPase That Targets the Membrane-Embedded Domain Impairing ATP Synthesis and Hydrolysis
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Dextromethorphan (DXM), a widely used antitussive agent, was investigated for its effects on mitochondrial F1FO-ATPase activity and oxidative phosphorylation. Our results demonstrate that DXM inhibited F1FO-ATPase independently of the thiol redox state. Mutual... ...
