Thiotaurine is a sulfane sulfur donor to the biological thiols glutathione and cysteine [0.03%]
硫醇噻奥磺通过向生物巯基谷胱甘肽和半胱氨酸供应回硫而产生硫烷硫的作用
Steven J Karpowicz
Steven J Karpowicz
Persulfide and hydrogen sulfide chemistry is relevant to the prevention of cellular oxidative damage. Thiotaurine is a poorly-studied precursor to the abundant biological molecule taurine and contains a labile sulfane sulfur. Here, reversib...
Spatiotemporal regulation of endocytic membrane trafficking by voltage-sensing phosphatase (VSP) in zebrafish enterocytes [0.03%]
电压感应型磷酸酶(VSP)通过时空调节斑马鱼肠上皮细胞内吞膜转运的作用机制研究
Adisorn Ratanayotha,Natsuki Mizutani,Fumiko Takenaga et al.
Adisorn Ratanayotha et al.
In developing vertebrates, nutrient uptake by specialized epithelial cells is primarily mediated by endocytosis, a process driven by dynamic phosphoinositide remodeling that regulates vesicle formation and endosomal maturation. Voltage-sens...
Anticancer activity of Pseudomonas fluorescens lectin (PFL) targeting high-mannose glycans on breast cancer cells [0.03%]
荧光假单胞菌凝集素（PFL）在靶向乳腺癌细胞高甘露糖聚糖的抗肿瘤活性中的作用
Yuichiro Sato,Kohei Kawabata,Chiho Murakami et al.
Yuichiro Sato et al.
Aberrant glycosylation is one of the key characteristics of cancer cells. High-mannose-type N-glycans are highly expressed in various types of cancer, making them potentially important therapeutic targets. As a basis for developing new ther...
Ectonucleotidases: Possible roles in the tumor microenvironment and influence on tumor progression in breast cancer [0.03%]
胞外核苷酸酶：乳腺肿瘤微环境中的可能作用及其对肿瘤进展的影响
Thaís Cristino Rocha-Vieira,José Roberto Meyer-Fernandes
Thaís Cristino Rocha-Vieira
Compared with nontumor tissue, the tumor microenvironment has a higher concentration of extracellular ATP. Extracellular ATP is degraded by the cooperative action of CD39 and ecto-5'-nucleotidase (CD73), thus leading to increases in the con...
Obese serum factors aggravate DNA damage, alter DNA damage response, and promote proliferation in colon cancer cells [0.03%]
肥胖血清因素加重结肠癌细胞的DNA损伤、改变DNA损伤应答并促进增殖
Bhavana Deshmukh,Himanshi Yaduvanshi,Firoz Khan Bhati et al.
Bhavana Deshmukh et al.
Clinical data indicate a positive association between obesity and DNA damage, which has been implicated in several pathological conditions. Obesity also increases the risk of the development and progression of cancers, including colon cance...
High-dose ascorbic acid prolongs the suppression of cell proliferation by enhancing intracellular oxidative stress-induced damage and inhibits invasion and adhesion in human fibrosarcoma HT-1080 cells [0.03%]
高强度抗坏血酸通过增强细胞内氧化应激诱导的损伤来延长对人纤维肉瘤HT-1080细胞增殖抑制的时间并抑制侵袭和黏附
Yasukazu Saitoh,Yusuke Tanimura,Shun Ueda et al.
Yasukazu Saitoh et al.
Pharmacological vitamin C (VC) infusion therapy has shown efficacy against various cancer types; however, there are few reports on its effects on fibrosarcoma. This study investigated the impact of high-dose ascorbic acid (AsA), the reduced...
COX-2 downregulation via G-quadruplex structure induction in the PTGS2-promoter region by mononuclear octahedral cobalt(III) Schiff base complex [CoL3] in colorectal cancer cells [0.03%]
介导的[colL3]单核八面体钴（III）席夫碱复合物在PTGS2启动子区通过G-四链体结构诱导COX-2下调在结直肠癌细胞中
Abdolvahab Moshtaghian,Abasalt Hosseinzadeh Colagar,Ali Khaleghian et al.
Abdolvahab Moshtaghian et al.
G-quadruplex structures within the promoter regions of some oncogenes diminish transcriptional activity. The suppression and downregulation of Cyclooxygenase-2 (COX-2), which is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) g...
TMED2 promotes thyroid cancer tumorigenesis by being involved in mTORC1-mediated fatty acid metabolism [0.03%]
TMED2通过参与mTORC1介导的脂肪酸代谢促进甲状腺癌的发生发展
Jiajun Yin,Shiping Wang,Yang Liu
Jiajun Yin
Background: TMED2, a p24 family member, has been implicated in the progression of multiple cancers. However, its function in thyroid cancer (THCA) is unclear and needs to be clarified. ...
Heterogeneous expression of the laminin-binding O-mannosyl glycan on α-dystroglycan in pancreatic cancer cell line MIA PaCa-2 and the correlation with cell properties [0.03%]
异种表达的O-岩藻糖聚糖在胰腺癌细胞系MIA PaCa-2上的α- dystroglycan和其与细胞属性的相关性研究
Rieko Imae,Yuuki Shichi,Satoshi Ninagawa et al.
Rieko Imae et al.
α-Dystroglycan (α-DG) is a central component of the dystrophin-glycoprotein complex, with the characteristic O-mannosyl glycan modification, which binds to several extracellular matrix proteins such as laminin. Disruption in the synthesis...
Involvement of neuropilin-1 in radiation-induced cell death via modulation of DNA double-strand break repair in glioblastoma T98G cells [0.03%]
神经纤毛蛋白-1通过调节DNA双链断裂修复参与胶质母细胞瘤T98G细胞的放射诱导死亡
Kaori Tsutsumi,Kouta Kawahara,Mizuki Kojima et al.
Kaori Tsutsumi et al.
Glioblastoma (GBM) is the most malignant form of brain tumor and is characterized by resistance to chemotherapy, radiotherapy, and combined chemoradiotherapy. Neuropilin-1 (NRP1) is a transmembrane receptor known to play critical roles in a...