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Ectonucleotidases: Possible roles in the tumor microenvironment and influence on tumor progression in breast cancer

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Compared with nontumor tissue, the tumor microenvironment has a higher concentration of extracellular ATP. Extracellular ATP is degraded by the cooperative action of CD39 and ecto-5'-nucleotidase (CD73), thus leading to increases in the concentrations of aden... ...