Tetrahydroquinoline/4,5-dihydroisoxazoline derivatives counteract multidrug resistance in cancer cells by inhibiting P-glycoprotein (ABCB1)-mediated transport [0.03%]
四氢异喹啉/四氢异亚硫酸酯衍生物通过抑制P-糖蛋白（ABCB1）介导的转运来对抗癌细胞的多重耐药性
Marina Hembecker,Diogo Henrique Kita,Azam Rashidian et al.
Marina Hembecker et al.
Cancer treatment is challenged by the emergence of multidrug resistance (MDR). MDR is often caused by the overexpression of certain ABC transporters, such as P-glycoprotein (P-gp, ABCB1) in the plasma membrane of tumor cells and tumor stem ...
Development of benzoxazole-2-yl-guanidine based Cu (II), Co (II), and Ni (II) complexes: Structural features, physicochemical aspects underpinning their pharmaceutical potential supported with theoretical approaches [0.03%]
基于苯并恶唑-2-基-胍𬭩的Cu（II），Co（II）和Ni（II）配合物的发展：结构特征，物理化学方面及其药物潜力的理论方法支持
Ahmed M Abu-Dief,Samar B Mohamed,Mehran Feizi-Dehnayebi et al.
Ahmed M Abu-Dief et al.
In this study, novel bioactive metal complexes of Cu (II), Co (II), and Ni (II) were synthesized using a guanidine-based ligand, 1,3-benzoxazole-2-yl-guanidine (L). The resulting coordination compounds [Cu(L)(CH₃COO)₂(H₂O)]·2H₂O, [Co(L...
Osmotic stress suppresses osteogenic differentiation by inhibiting nuclear translocation of YAP via perinuclear actin accumulation [0.03%]
渗透胁迫通过核周肌动蛋白积累抑制YAP核转位从而抑制骨形成分化
Takashi Miyano,Haruka Hasegawa,Toshihiro Sera
Takashi Miyano
Hyperglycemia is a well-recognized cause of osteoblast dysfunction. Recent evidence, however, indicates that elevated extracellular osmolarity associated with hyperglycemia may independently impair osteogenic differentiation. However, the m...
Ursolic acid activates SIRT6 by enhancing enzyme-substrate interactions and promoting protein structural rearrangement [0.03%]
乌索酸通过增强酶-底物相互作用和促进蛋白质结构重排来激活SIRT6
Zohreh Tabatabaian Nimavard,Nuredin Bakhtiari,Fereshteh Taghavi et al.
Zohreh Tabatabaian Nimavard et al.
Ursolic acid (UA) has emerged as a promising bioactive compound with potential therapeutic effects, particularly in the upregulation of SIRT6, an important protein involved in various cellular processes, including longevity, stress response...
Cavin-3 promotes TNF expression via the MAPK signaling pathway in lung squamous cell carcinoma [0.03%]
Cavin-3通过MAPK信号通路促进肺鳞状细胞癌中TNF的表达
Xiaoyan Xu,Yonghong Nie,Jiatuo Xu et al.
Xiaoyan Xu et al.
Cavin family proteins alter the invasiveness of tumor cells. However, research on the pathogenesis of Cavins in tumors is lacking. To address this knowledge-gap, we conducted a systematic analysis about the mechanism of action of Cavins in ...
Receptor binding domain of SARS CoV2 spike protein exhibits in vitro liquid-liquid phase separation due to structural disorderedness that may challenge the vaccine-generated antibody binding [0.03%]
SARS-CoV-2刺突蛋白受体结合域由于结构无序而在体外发生液-液相分离，这对疫苗诱导的抗体产生提出了挑战
Manikanta Sodasani,Abhinav V K S Grandhi,Niharikha Mukala et al.
Manikanta Sodasani et al.
In this study we expressed, purified and demonstrated the protein liquid-liquid phase separation (LLPS) formation by the receptor binding domain (RBD) of coronavirus spike protein in vitro. Our molecular dynamics simulations revealed multip...
Decoding chromatin nanoscale plasticity in situ: Insights from native AFM imaging [0.03%]
从原位AFM成像中解读染色质的亚纳米尺度可塑性：来自天然AFM成像的见解
Hongfeng Cui,Yu Zhang,Tianyu Chen et al.
Hongfeng Cui et al.
Chromatin structure and its plasticity are central to gene regulation and DNA-associated processes, yet their nanoscale architecture and dynamic assembly remain elusive. Here, we propose a novel in situ approach-combining hypotonic treatmen...
The effect of gold nanoparticle size and shape on the structure and activity of Domain 3 of an alternative sigma factor of Staphylococcus aureus [0.03%]
金纳米颗粒的尺寸和形状对金黄色葡萄球菌替代型σ因子结构域3的结构与活性的影响研究
Tanaya Chatterjee,Debasmita Sinha
Tanaya Chatterjee
Background: The modern era has witnessed the vast applications of nanoparticles (NPs) ranging from drug delivery to biomedical usages. Herein we report for the first time the effect of gold nanoparticles (AuNPs) of differ...
Histidine betaine trimethylammonia-lyase, enzyme coupled with terminal urocanate reductase in Shewanella woodyi grown anaerobically [0.03%]
希瓦氏菌伍迪株厌氧生长时组氨碱性三甲胺异生成与终端尿刊酸还原酶偶联的酶
Yulia V Bertsova,Marina V Serebryakova,Alexander A Baykov et al.
Yulia V Bertsova et al.
Bacteria coping with oxygen deficiency can switch to alternative terminal electron acceptors, which can be normal metabolic intermediates or products of dedicated coupled reactions. In the latter case, the genes for the respective terminal ...
Hepatic response to ethanol feeding in a hepatocyte-specific fatty acid binding protein-4 knock out mouse model [0.03%]
乙醇喂养下肝细胞特异性脂肪酸结合蛋白-4敲除小鼠模型的肝脏应答
Neha Attal,Trenton Pritt,Melissa Stair et al.
Neha Attal et al.
Background: Early alcohol-dependent liver disease (ALD) is characterized by increased hepatic fat storage (hepatosteatosis). Fatty acid binding protein 4 (FABP4), a protein not normally expressed in liver, becomes highly ...