Tetrahydroquinoline/4,5-dihydroisoxazoline derivatives counteract multidrug resistance in cancer cells by inhibiting P-glycoprotein (ABCB1)-mediated transport
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Cancer treatment is challenged by the emergence of multidrug resistance (MDR). MDR is often caused by the overexpression of certain ABC transporters, such as P-glycoprotein (P-gp, ABCB1) in the plasma membrane of tumor cells and tumor stem cells. Inhibition of... ...
