Plasmin contributes to arthritis pain by cleaving proteinase activated receptor-4 in rats [0.03%]
纤溶酶通过裂解蛋白酶激活受体-4在大鼠体内参与类风湿性关节炎痛觉形成
Jason J McDougall
Jason J McDougall
Proteinase activated receptors (PARs) are family of four G protein-coupled receptors that signal following enzymatic cleavage of their extracellular N-terminal domain. Activation of PAR-4 has been found to sensitize joint nociceptors leadin...
Proteomic profiling of the prefrontal cortex reveals Dysregulated Mitochondria-Metabolism-Synapse axis in a chronic Stress-Induced mouse model of depression [0.03%]
蛋白质组分析发现慢性压力诱导的小鼠抑郁症模型中线粒体-代谢-突触轴失调
Yi Zhang,Lei Li,Xiaowei Zhang et al.
Yi Zhang et al.
Major depressive disorder (MDD) is a highly prevalent and disabling neuropsychiatric condition, its underlying molecular mechanisms remain incompletely understood. This study aimed to systematically characterize proteomic alterations in the...
Inhibition of the NF-κB/STAT3 pathway to reduce spinal microglia activation: a mechanism by which manual acupuncture alleviates rheumatoid arthritis [0.03%]
NF-κB/STAT3信号通路抑制减少脊髓小胶质细胞激活：针刺治疗类风湿性关节炎的机制
Qiang Zhang,Yilin Wang
Qiang Zhang
Background: Rheumatoid arthritis (RA) discomfort is linked to spinal cord microglia activation. Manual acupuncture (MA, twirling manipulation) reduces RA pain. MA's ability to relieve RA discomfort was examined in this st...
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice [0.03%]
选择性上调基底外侧杏仁核中的脂肪酸结合蛋白5可减弱小鼠应激诱导的可卡因寻求行为的复现
Nicole Roeder,Aidan Powell,John Hamilton et al.
Nicole Roeder et al.
Anandamide (AEA), an endogenous cannabinoid, is thought to exert an inhibitory role in the basolateral amygdala complex (BLA), dampening hypothalamus-pituitary-adrenal (HPA) axis activation and reducing stress-related fear and anxiety behav...
Pentosidine accumulation induced by Akr1a deficiency Drives aggression and hyperactivity [0.03%]
Akr1a缺失引起的Pentosidine累积导致攻击性和过度活跃行为
Kyoka Iino,Kazuya Toriumi,Mitsuhiro Miyashita et al.
Kyoka Iino et al.
Advanced glycation end products (AGEs) are a heterogeneous group of glycation-derived compounds that accumulate under metabolic stress and contribute to age-related and chronic diseases. Pentosidine (PEN), a well-characterized fluorescent A...
Activation of taf7l promotes sensory nerve regeneration by enhancing conditioning effect [0.03%]
TAf7L激活通过增强环境富集作用促进感觉神经再生
Kaori Sugiura,Takao Omura,Jili Wang et al.
Kaori Sugiura et al.
Peripheral nervous system (PNS) neurons can regenerate after injury, yet functional recovery is often limited, especially following proximal lesions or delayed repair. Preconditioning nerve injury accelerates axonal growth by inducing regen...
Corrigendum to "TMEM119-positive microglia were increased in the brains of patients with amyotrophic lateral sclerosis" [Neurosci. Lett. 833 (2024) 137829] [0.03%]
“唐氏综合征患者脑中TMEM119阳性小胶质细胞增多”一文的勘误[ neuroscience letter 833 (2024) 137829]
Natsuko Togawa,Takashi Ayaki,Daisuke Yoshii et al.
Natsuko Togawa et al.
Published Erratum
Neuroscience letters. 2026 Feb 20:138544. DOI:10.1016/j.neulet.2026.138544 2026
Inhibition of Death-Associated Protein Kinase 1 ameliorates central and peripheral pathological changes in a mouse model of Parkinson's disease [0.03%]
抑制死亡相关蛋白激酶1改善帕金森病小鼠模型的中枢和外周病理变化
Zhining Li,Zhengwei Chen,Zuowei Duan et al.
Zhining Li et al.
Background: Parkinson's disease (PD) is a multisystem neurodegenerative disorder affecting both the central nervous system (CNS) and the enteric nervous system (ENS). Growing evidence implicates gut-brain axis dysfunction...
Target epigenetics mechanism to prevent synaptic dysfunction of adult amblyopia [0.03%]
靶向表观遗传机制以预防成人弱视的突触功能障碍
Suzhen Ding,Yong Li,Qian Cao et al.
Suzhen Ding et al.
Amblyopia is a neurodevelopmental disorder, and there are no effective treatment methods for adult amblyopia patients due to the decline in synaptic plasticity in visual cortex. Enriched environment (EE) has been shown to enhance synaptic p...
Hydrogen sulfide protects dopaminergic neurons via NLRP3 inflammasome inhibition in an MPTP mouse model of Parkinson's disease [0.03%]
氢硫化物通过NLRP3炎性小体抑制作用保护多巴胺能神经元：以MPTP诱导的小鼠帕金森病模型中的研究为例
Ke-Ting Liu,Yulian Shui,Jia Hong et al.
Ke-Ting Liu et al.
Background: Hydrogen sulfide (H2S) has emerged as a potential neuroprotective agent in neurodegenerative diseases, including Parkinson's disease (PD). However, its role in regulating neuroinflammation through the NLRP3 in...