Hemorphin LVV-H3 attenuates calcineurin activity and regulates cytokine levels in experimental Parkinson's disease [0.03%]
血morphin LVV-H3通过减弱钙调神经磷酸酶活性及调节细胞因子水平来缓解实验性帕金森病
Flora Sarukhanyan,Ovsanna Hunanyan,Hermine Zakaryan et al.
Flora Sarukhanyan et al.
Dysregulation of intracellular Ca2+ levels and activation of the Ca2+/calmodulin-dependent phosphatase calcineurin (CaN) contribute to neurodegeneration and inflammatory responses associated with the Parkinson's disease (PD) pathogenesis. H...
Exercise-induced irisin rescues lead-induced cognitive impairment by inhibiting prefrontal cortical senescence via SIRT3 [0.03%]
运动诱导irisin通过SIRT3抑制前额叶皮质衰老从而缓解铅引起的学习记忆障碍
Hui Huang,Huiyuan Shi,Jian Sun et al.
Hui Huang et al.
Lead (Pb) is a pervasive environmental hazard that impairs cognitive function. However, the underlying mechanisms and non-pharmacological interventions need to be further investigated. Here, Pb-induced senescence in the prefrontal cortex wa...
Increased NMDA receptor GluN2A-type ionotropic signaling is sufficient to improve spatial memory in immature mice [0.03%]
在不成熟的鼠标中，增加的N-甲基-D天冬氨酸受体GluN2A型离子信号足以改善空间记忆
Ama S Boakye-Agyei,Daniela D M Rodrigues-Henry,Diego A Gonzalez et al.
Ama S Boakye-Agyei et al.
Spatial learning and memory are reliant on activation of N-methyl-D-aspartate receptors (NMDARs) at excitatory synapses in the hippocampus. NMDARs at immature synapses contain mostly GluN2B subunits while at mature synapses, more NMDARs con...
Effects of chronic levodopa in the paraquat and lectin rat model of the "body-first" subtype of Parkinson's disease [0.03%]
左旋多巴在慢性百草枯和凝集素大鼠帕金森病“身体优先型”模型中的作用研究
Caroline Swain,Dipesh Pokharel,Vaibhavi Peshattiwar et al.
Caroline Swain et al.
Recent studies have identified a "body-first" subtype of Parkinson's disease (PD) that is associated with more rapid progression to Parkinson's disease dementia (PDD). It is currently unknown whether chronic levodopa, the primary treatment ...
Unpredictable chronic stress fails to induce robust changes in zebrafish social behavior [0.03%]
不可预测的慢性压力不会引起斑马鱼社交行为的显著变化
Náthali A Neves,Matheus Gallas-Lopes,Amanda Patelli-Alves et al.
Náthali A Neves et al.
Stress-related disorders encompass diverse behavioral alterations, including impaired social functioning. The zebrafish (Danio rerio) is a valuable model for studying these phenomena, particularly because of its robust and ethologically con...
Betahistine attenuates vestibular stimulation-induced mitochondrial damage and neuroinflammation in Deiters' neurons [0.03%]
β-组胺可通过减轻迪特尔神经元线粒体损伤和小胶质细胞介导的神经炎症来缓解前庭刺激导致的眩晕症状
Natalya S Zhuikova,Irina B Mikheeva,Olga Yu Antonova et al.
Natalya S Zhuikova et al.
Dysfunction of the vestibular nuclei, which can arise from various causes, is a common problem, affecting more than a third of people over 40. Its characteristic symptom is vestibular vertigo. This dysfunction is also associated with neurod...
Gene transcription and mRNA translation requirements for long-term excitability changes induced by aversive experience in the feeding neural circuit of Aplysia [0.03%]
阿伏加德素觅食神经回路中不良经历诱导的长期兴奋性变化中的基因转录和mRNA翻译要求
Robert T Mueller,Marcy L Wainwright,Riccardo Mozzachiodi
Robert T Mueller
Long-term memory formation requires gene transcription followed by mRNA translation. Research in Aplysia has revealed that behavioral training, consisting of repeated exposure to aversive stimuli, induces a persisting transcription- and tra...
Corrigendum to "Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage" [Neurosci. Lett. 733 (2020) 135142] [0.03%]
关于“异氟醚与七氟醚对实验性蛛网膜下腔出血后脑早期损伤及鞘氨醇激酶1表达的影响”的勘误[神经科学通讯733（2020）135142]
Orhan Altay,Hidenori Suzuki,Bilge Nur Altay et al.
Orhan Altay et al.
Published Erratum
Neuroscience letters. 2026 Apr 15:876:138578. DOI:10.1016/j.neulet.2026.138578 2026
Complicated regulation of the activity of a single interneuron through rigid synaptic connections with asymmetric salt-sensory neurons in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫中通过固定连接的味觉神经元调节单个中间神经元活性的机制研究
Masahiro Kuramochi,Motomichi Doi
Masahiro Kuramochi
Sensory inputs are integrated by interneurons to generate appropriate behavioural outputs. In the nematode Caenorhabditis elegans, the AIY interneuron receives major synaptic input from the salt-sensing ASE neurons, ASEL and ASER, which res...
Cromolyn inhibits PGE2-mediated sensitisation of TRPV1 in a GPR35-dependent manner in sensory neurons [0.03%]
环孢素通过感觉神经元中的GPR35依赖性方式抑制PGE2介导的TRPV1敏化作用
James P Higham,Luke W Paine,Alanna Cameron et al.
James P Higham et al.
There is a pressing need for effective alternatives to opioid analgesics, the development of which requires the identification of novel anti-nociceptive drug targets. Here, we have further investigated the anti-nociceptive properties of a G...