Chlorogenic acid exerts anti-inflammation and neuroprotective effect in pentylenetetrazole-induced epilepsy mouse model by regulating microglia polarization via Nrf2/HO-1 pathway [0.03%]
氯ogenic酸通过Nrf2/HO-1信号通路调节小胶质细胞极化对戊四唑诱导的癫痫小鼠模型发挥抗炎和神经保护作用
Yi Sun,Jiayu Wang,Aoyuan Zhang et al.
Yi Sun et al.
Chlorogenic acid (CGA) possesses diverse biological functions, including antioxidant, anti-inflammatory, and anti-apoptotic, both in vitro and in vivo. Recent studies have suggested that CGA also has neuroprotective effects. However, its po...
Antinociceptive role of IL-10/STAT3 signaling in trigeminal neuropathic pain male rat model through Pomc and β-endorphin [0.03%]
白细胞介素10/信号转导子和转录激活子3信号在三叉神经病理性痛雄性大鼠模型中的镇痛作用及促黑激素和β-内啡肽的作用机制研究
Lutfi Putra Perdana,Jaime Fabillar Jr,Dara Sari Arini et al.
Lutfi Putra Perdana et al.
Interleukin-10 (IL-10) is a cytokine that can exert an analgesic effect on trigeminal neuropathic pain (TNP). However, its precise mechanism remains unclear. In this study, we investigated the antinociceptive effects of recombinant IL-10 (r...
Suppression of 5-HT2 receptor signaling impairs normal eye development in zebrafish [0.03%]
五羟色胺2型受体信号转导被抑制会影响斑马鱼正常的眼睛发育
Zulvikar Syambani Ulhaq,Mitsuyo Kishida
Zulvikar Syambani Ulhaq
Serotonin (5-HT) signaling plays essential roles in vertebrate development beyond neurotransmission, including in ocular morphogenesis. Here, we investigated the effects of Ritanserin, a non-selective 5-HT2 receptor antagonist, on zebrafish...
The effects of lithium chloride in N-methyl-N-nitrosourea induced retinal damage in rats [0.03%]
氯化锂对N-甲基-N-亚硝基脲致大鼠视网膜损伤的影响
Canan Akdeniz İncili,Yesari Eröksüz,Hatice Eröksüz et al.
Canan Akdeniz İncili et al.
The aim of the current study was to assess the potential neuroprotective effects of lithium chloride (LiCl) against retinal degeneration (RD) induced by N-methyl-N-nitrosourea (MNU) in the rats. 108 rats were assigned to 6 groups: Control, ...
Bovine lactoferrin-induced antinociception through 5-HT1A/1D receptors in formalin-induced tonic pain [0.03%]
牛乳铁蛋白通过5-ht1a / 1d受体诱导甲醛引起的持续痛的镇痛作用
Sergio Ernesto Ávila-Morales,Maria Elisa Drago-Serrano,Beatriz Godínez-Chaparro
Sergio Ernesto Ávila-Morales
Bovine lactoferrin (bLF) is a multifunctional glycoprotein that displays modulatory effects on pain through pathways not fully known. Therefore, we determined the role of the serotonergic system as a potential mechanism underlying the antin...
The anti-epileptic mechanism of a ketogenic diet regulating the gut microbiota via SIRT2 activation of the PI3K/AKT signaling pathway [0.03%]
生酮饮食通过激活SIRT2介导的PI3K/AKT信号通路调节肠道菌群从而发挥抗癫痫作用的机制研究
Minghua Li,Haifeng Deng,Ling Ma et al.
Minghua Li et al.
Purpose: Epilepsy (EP) is a disorder caused by sudden abnormal discharges of neurons in the brain. A ketogenic diet (KD) has significant anticonvulsant effects in some epileptic patients, but the signaling pathway remains...
MEGF10 knockout promotes cortical and hippocampal amyloid deposition in AD mouse model [0.03%]
MEGF10敲除促进AD小鼠模型皮质和海马区淀粉样蛋白沉积
Yu Fujita,Taichi Yabe,Yoshikazu Yamada et al.
Yu Fujita et al.
Multiple epidermal growth factor (EGF)-like domains 10 (MEGF10) is a single-pass transmembrane protein expressed in neurons and astrocytes, functioning as a phagocytic receptor for apoptotic cells and mediating homotypic adhesion in the mam...
NNT inhibits microglial activation via mitochondrial oxidative stress in spinal cord injury [0.03%]
NNT通过抑制脊髓损伤中的线粒体氧化应激来抑制小胶质细胞活化
Ming Li,Qiuyue Gu,Zhenyu Fan et al.
Ming Li et al.
Spinal cord injury (SCI) is a major public health challenge, often leading to severe neurological and physical disabilities. Microglia, the primary immune cells in the spinal cord, play critical roles in both the physiology and pathology of...
The impact of guanethidine-induced sympathectomy on satellite glial cell activation in a rat model of neuropathic pain [0.03%]
胍乙啶交感神经切除术对痛觉过敏模型中卫星神经胶细胞活化的影响
Xicun Han,Xiaohua Jiang,Yabin Liu et al.
Xicun Han et al.
The involvement of satellite glial cells (SGCs) in neuropathic pain has been well-established; however, it remains unclear whether the sprouted sympathetic fibers within the dorsal root ganglion (DRG) after peripheral nerve injury affect th...
Facilitation of supplementary motor area activity modulates the sense of effort: a theta burst stimulation study [0.03%]
体感诱发补充运动区活动可调节努力感觉：一项θ爆发刺激研究
Taishi Okegawa,Daiki Yamasaki,Naotsugu Kaneko et al.
Taishi Okegawa et al.
The sense of effort, defined as the phenomenological experience of invested physical resources in the task, is a critical component of motor control. The supplementary motor area (SMA) has been implicated in generating this sense, yet it re...