Hybrid molecules with dual inhibition of acetylcholinesterase and tau hyperphosphorylation: design, inhibitory activity evaluation, apoptosis assessment, and mechanistic exploration [0.03%]
兼具乙酰胆碱酯酶抑制和Tau蛋白过度磷酸化抑制的杂合分子的设计、活性评价、抗凋亡作用评估及机制研究
Qingfeng Hu,Kai Xu,Qingnian Ran et al.
Qingfeng Hu et al.
A comprehensive therapeutic strategy for Alzheimer's disease (AD) requires simultaneous inhibition of acetylcholinesterase (AChE) and targeting of hyperphosphorylated Tau (P-Tau)-mediated pathogenesis. To address this need, the present stud...
Potent Carbonic Anhydrase Inhibition by Ruthenium(II)-Acetazolamide Conjugates Uncoupled from Antiproliferative Activity In Vitro [0.03%]
分离出的钌(II)-醋唑胺缀合物具有强力的碳酸酐酶抑制活性但无体外抗增殖作用
Alberto Gobbo,Simone Giovannuzzi,Maria Luisa Massardi et al.
Alberto Gobbo et al.
The novel ruthenium(II) complexes [RuCl(κ3N-tpm)(PPh3)(κ1N-AcmH2)]Cl (5) and [Ru(κ3N-tpm)(PPh3)(κ2N,N'-AcmH)]NO3 (6) were synthesized in 46-57% yields via thermal reactions of [RuCl(κ3N-tpm)(PPh3)2]Cl (4) with AcmH2, conducted in THF a...
Expanding the reactive chemistry toolbox - warhead screening for covalent butyrylcholinesterase inhibitors [0.03%]
扩展反应化学工具箱-丙二酸酯共价胆碱酯酶抑制剂的弹头筛选
Anže Meden,Xavier Brazzolotto,José Dias et al.
Anže Meden et al.
Many covalent inhibitors of butyryl- and acetylcholinesterase, typically featuring electrophilic carbamoyl, phosphonyl, and sulfonyl groups, were reported in the literature. In this study, we screened these and several other electrophilic m...
Investigating the neurodevelopmental toxicity of graphene oxides using 3D human brain organoids and zebrafish models: emphasis on GABAergic neuron alterations at single-cell resolution [0.03%]
利用三维人类脑器官和斑马鱼模型研究氧化石墨烯的神经发育毒性：强调单细胞分辨率下GABA能神经元的变化
Yuna Chen,Weichao Zhao,Lu Gan et al.
Yuna Chen et al.
Exposure to graphene oxides (GOs) may induce neurotoxic effects, but the mechanisms and extent of these effects remain unclear, partly due to limitations in traditional neurotoxicity models. In this study, we utilized 3D human brain organoi...
Multi-omics decoding of Phalloidin hepatotoxicity: network toxicology-guided identification of FoxO/PLD/cAMP signaling targets [0.03%]
鹅膏毒红肽肝毒性多组学解码及网络毒理学引导的FoxO/PLD/cAMP信号通路靶标识别研究
Shaofang Lv,Yaozhen Gong,Hua Guo et al.
Shaofang Lv et al.
Phalloidin is a lethal toxin found in highly toxic mushrooms of the genus Amanita; it causes severe liver injury, yet its molecular mechanism has not been systematically elucidated. In this study, Male Kunming mice received a single intrape...
Total esterase and paraoxonase activity in human saliva of periodontitis patients and healthy individuals; a pilot study [0.03%]
牙周炎患者和健康个体中人唾液总酯酶和对氧磷酶活性的研究；一项初步研究
Rok Gašperšič,Ajda Taler-Verčič,Boštjan Petrič et al.
Rok Gašperšič et al.
This pilot study evaluated total esterase activity and PON-1 activity in unstimulated and stimulated saliva of periodontitis patients and healthy subjects focusing on relation to clinical data, salivary flow rate, pH, total protein concentr...
HIF-1α/BNIP3L-mediated mitophagy is involved in T-2 toxin-induced myocardial injury [0.03%]
差噬素HIF-1α/Bnip3L介导的线粒体自噬参与T-2毒素致心肌损伤作用及机制研究
Qian Li,Miao Wang,Juan Zuo et al.
Qian Li et al.
T-2 toxin, the most toxic type A mycotoxin, induces cardiotoxicity and impairs cardiac function. Herein, we investigated the regulatory role of mitophagy in T-2 toxin-induced myocardial injury. Using the Comparative Toxicogenomics Database,...
Polystyrene nanoparticles promote endometrial cancer progression via downregulation of UGT1A genes [0.03%]
聚苯乙烯纳米颗粒通过下调UGT1A基因促进子宫内膜癌进展
Liping Zhang,Yueying Li,Xiaonan Cai et al.
Liping Zhang et al.
The widespread environmental presence of polystyrene nanoparticles (PS-NPs) and their potential health risks have become a growing concern. Concurrently, mortality rates associated with endometrial cancer (EC) have significantly increased i...
Per- and polyfluoroalkyl substances trigger autoimmune diseases through inflammatory cytokines-IL-17/Th17 signaling axis [0.03%]
含氟化合物通过炎症细胞因子-IL-17/Th17信号轴诱发自身免疫疾病
Qi Cheng,Yifan Xie,Yingying Hou et al.
Qi Cheng et al.
This study systematically investigates the mechanisms by which per- and polyfluoroalkyl substances (PFAS) promote immune dysregulation and trigger autoimmune diseases (ADs). Using an integrated network toxicology and bioinformatics approach...