Preface on Special Issue 15th International Meeting on Cholinesterases and 9th Conference of Paraoxonases [0.03%]
乙酰胆碱酯酶国际会议第十五次会议及卵磷脂胆固醇acs转移蛋白国际会议第九次会议特刊前言
Marko Goličnik,Aljoša Bavec,Stanislav Gobec
Marko Goličnik
Synergistic neurotoxicity of mono-butyl phthalate and bisphenol A at environmentally relevant concentrations: Multi-Omics evidence for ferroptosis via glutathione metabolism disruption in neural stem cells and brain organoids [0.03%]
单正丁基邻苯二甲酸酯和双酚A在环境相关浓度下的协同神经毒性：神经干细胞和脑类器官中谷胱甘肽代谢紊乱引发铁死亡的多组学证据
Yunpeng Li,Fengzhen Cui,Huanwen Tang
Yunpeng Li
Evaluating endocrine-disrupting chemicals (EDCs) risk such as mono-butyl phthalate (MBP) and bisphenol A (BPA) raises a pressing question: can doses deemed safe for each individual exposure become hazardous in combination? This study aimed ...
A Novel Approach Against Amitraz Toxicity Based on Magnetic Extraction Using native β-Cyclodextrin and β-Cyclodextrin Polymers attached to Superparamagnetic Nanoparticles for potential Human Cell Protection [0.03%]
基于磁提取的新型阿米太唑毒性防治方法：利用原生β-环糊精和超顺磁纳米粒子连接的β-环糊精聚合物实现人体细胞保护
F Franco-Campos,Y Rodríguez-Carrasco,A Riveros et al.
F Franco-Campos et al.
Amitraz (AMZ) is a pesticide widely used for apiculture and agriculture, resulting in residues potentially contaminating hive products and increasing the risk of human exposure. In this work, we developed a water-compatible supramolecular s...
DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation [0.03%]
基于TSPO介导的软骨毒性的体外和体内实验验证DINCH暴露参与骨关节炎发病机制
Jingxin Pan,Xi Wang,Ying Gao et al.
Jingxin Pan et al.
Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a widely used plasticizer substitute, has been widely detected in human populations and has emerged as a new environmental pollutant of growing concern. Despite the established association b...
Targeting the NOX4/NLRP Inflammasome Axis Confers Protection by Isoliquiritigenin Against H2O2-Induced Synovial Inflammation [0.03%]
异鼠李素通过靶向NOX4/NLRP炎性小体轴对抗H2O2诱导的滑膜炎症作用研究
Yu-Chun Chang,Wei-Wen Kuo,Yen-Pin Chen et al.
Yu-Chun Chang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Fibroblast-like synoviocytes (FLS) play a central role in RA pathogenesis by promoting inflammato...
DAF-16/FOXO insulin signaling modulates F-53B toxicity by regulating intestinal redox homeostasis and permeability in Caenorhabditiselegans [0.03%]
daf-16/FOXO胰岛素信号通过调节肠道氧化还原稳态和通透性调控F-53B毒性的分子机制研究(CeMS0024)
Qinlin Wu,He Chen,Man Qu
Qinlin Wu
Although 6:2 Chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFES, F-53B) is gaining popularity in China as an alternative to perfluorooctane sulfonate (PFOS), its environmental effects on organisms are still not fully understood. This ...
PFOA promotes PMAIP1-MCL1 apoptotic vulnerability within a BHLHE41-associated macrophage regulatory architecture in atherosclerosis [0.03%]
PFOA促进动脉粥样硬化中与BHLHE41相关的巨噬细胞调控结构内的PMAIP1-MCL1凋亡脆弱性
Hou-Liang Chen,Run Wang,Wei-Jun Tao et al.
Hou-Liang Chen et al.
Perfluorooctanoic acid (PFOA), a legacy per- and polyfluoroalkyl substance (PFAS), has been associated with dyslipidemia and adverse cardiovascular phenotypes, yet the plaque-macrophage mechanisms that may connect exposure to lesion biology...
The first comprehensive toxicity profile of nitazenes - benzimidazole opioids (butonitazene, etonitazene, isotonitazene, metonitazene and protonitazene): application of in silico methodology for the prediction of key toxicological parameters important from clinical and forensic point of view [0.03%]
硝坦挫类（丁氨挫新，埃他氨挫新，异丙氨挫新，美沙氨挫新和丙氨挫新）苯并咪唑阿片类药物的第一份全面毒性评估：应用计算机模拟预测临床及法医角度下重要的毒理学参数
Łukasz Niżnik,Kamil Jurowski
Łukasz Niżnik
Nitazenes - ultrapotent synthetic opioids from the 2-benzylbenzimidazole class, have re-emerged on illicit drug markets despite being abandoned in the 1950s due to life-threatening respiratory depression and extreme abuse potential. Their s...
ER stress-dependent Ddit4/REDD1 induction contributes to translational suppression during cisplatin-induced skeletal muscle atrophy [0.03%]
内质网应激依赖的Ddit4/REDD1诱导参与顺铂引起的骨骼肌萎缩过程中的翻译抑制作用
Hayato Nanri,Hiroyasu Sakai,Kaisei Umeyama et al.
Hayato Nanri et al.
Cisplatin is a widely used chemotherapeutic agent whose clinical utility is limited by various adverse effects. Although skeletal muscle loss during chemotherapy is often attributed to cachexia or generalized wasting, accumulating evidence ...
Sex-specific differences in cadmium accumulation and responses in the freshwater snail Cipangopaludina cathayensis [0.03%]
镉积累及赤玉螺的响应性别差异研究
Wei Jinyou,Xiang Shanshan,Yu Jing et al.
Wei Jinyou et al.
Cadmium (Cd) is a non-essential element with strong toxicity to aquatic mollusks. Although sex-specific Cd accumulation has been reported, the distinct impacts on males and females and their adaptive strategies remain unclear. We exposed fr...