Pyraclostrobin triggers pulmonary inflammation, oxidative stress, and fibrosis in mouse via Wnt/β-catenin signaling [0.03%]
嘧菌酯通过Wnt/β-连环蛋白信号引起小鼠肺部炎症、氧化应激和纤维化
Jun Wang,Shihua Li,Yan Cao et al.
Jun Wang et al.
Pyraclostrobin (PYR), a broad-spectrum fungicide, is known for its aquatic toxicity, yet its mammalian toxicity remains poorly understood. This study utilized a network pharmacology approach to predict GSK3β as a potential target of PYR, f...
Sulfur mustard exposure induces inflammatory injury by Dnmt3b-mediated DNA methylation via oleic acid accumulation in Treg cells [0.03%]
哈雷芥子气通过Treg细胞中油酸积累诱导Dnmt3b介导的DNA甲基化引起炎症损伤
Yunrui Sun,Xianrui Jiang,Jinfeng Cen et al.
Yunrui Sun et al.
Sulfur mustard (SM), a hazardous chemical warfare agent, poses severe threats to environmental safety and public health due to its persistent toxicity. While the blistering effects of SM are well documented, its impact on the immune system ...
Structure-dependent inhibition of human carboxylesterase 1 by organophosphate esters: integrated in vitro profiling and 3D-QSAR interpretation [0.03%]
人羧酸酯酶1由磷酸酯抑制的结构依赖性：基于体外综合分析和三维定量结构活性关系的解释
Zhuohua Cao,Siyu Men,Zhenhua Li et al.
Zhuohua Cao et al.
Organophosphate esters (OPEs) are widespread environmental contaminants increasingly recognized for their metabolic-disruption potential. However, systematic cross-structure comparisons of their inhibitory effects on human carboxylesterase ...
Response to "Reflection about articaine: in vitro studies and clinical data" by Branco & Santos, Chemico-Biological Interactions 2026, Jan 26; 423: 111816 [0.03%]
对Branco&Santos《关于 articaine 的思考：体外研究和临床数据》的回复
Gustavo Henrique Rodrigues da Silva,Eneida de Paula
Gustavo Henrique Rodrigues da Silva
The pivotal regulatory factor circ_0006956 promotes arsenic-induced lung carcinogenesis by enhancing the Warburg effect [0.03%]
环状RNA circ_0006956通过增强瓦博格效应促进砷诱导的肺癌发生发展
Deqing Li,Xiaodong Zhou,Dunyu Cai et al.
Deqing Li et al.
Arsenic (As) is a widespread environmental carcinogen. Long-term exposure to arsenic significantly increases the risk of lung cancer. In recent years, circRNAs have attracted widespread attention because of their crucial roles in tumorigene...
Exposure to polyethylene microplastics induces a male testosterone synthesis disorder via oxidative stress-mediated ferroptosis [0.03%]
聚乙烯微塑料通过氧化应激介导的铁死亡诱导雄性睾丸酮合成障碍
You Yang,Lingling Zhai,Siyu Wang et al.
You Yang et al.
Polyethylene microplastics (PE-MPs) have been shown to induce male reproductive toxicity in male mice but the mechanism underlying this toxicity is poorly understood. To address this knowledge gap, in vivo and in vitro experiments were perf...
Elaidic acid induces hepatic lipid accumulation by inhibiting chaperone-mediated autophagy via the GAS5/miR-27b-3p/SNX10 axis [0.03%]
GAS5/miR-27b-3p/SNX10轴抑制伴侣介导的自噬诱导油酸致肝脂质蓄积
Yuelin Chen,Junzhu Feng,Lingxi Lang et al.
Yuelin Chen et al.
The intake of industrial trans-fatty acids (iTFAs), particularly elaidic acid (EA), has been implicated in non-alcoholic fatty liver disease (NAFLD), yet the underlying mechanisms remain incompletely understood. Functional chaperone-mediate...
5-Ethynyl-2'-deoxyuridine (EdU) regulates apoptosis, autophagy, and cell cycle dynamics in 2D and 3D U87-MG glioma cells [0.03%]
5-乙炔脱氧尿苷（EdU）调节二维和三维U87-MG胶质瘤细胞的凋亡、自噬及细胞周期动力学
Ceren Gencel Güler,Evren Önay Uçar
Ceren Gencel Güler
Glioblastoma (GB) is one of the most aggressive brain tumours, with low survival rates despite combined radiation and chemotherapy. The blood-brain barrier (BBB) limits the delivery and efficacy of many chemotherapeutic agents, highlighting...
Cylindrospermopsin-induced metabolic reprogramming mapped in rat tissues by MALDI imaging [0.03%]
基质辅助激光解析电离成像测定鱼腥藻素P诱导的代谢重编程
Antonio Casas-Rodríguez,Cristina María López,Angela Peralbo-Molina et al.
Antonio Casas-Rodríguez et al.
Cylindrospermopsin (CYN) is a cyanobacterial toxin with hepatotoxic and nephrotoxic properties; however, its spatial distribution and molecular effects in mammalian tissues remain unclear. In this study, matrix-assisted laser desorption/ion...
Yi Liu,Hao Wei,Jing Zhang et al.
Yi Liu et al.
Nicotine, as the main bioactive component in tobacco, activates the nicotinic acetylcholine receptors (nAChRs) in the nervous system, triggering a series of complex neurobiological responses, thereby facilitating the formation and maintenan...