Circulating Mitokines GDF-15 and FGF21 are associated with Frailty, Sarcopenia, and Malnutrition in Older Adults: Evidence from the FRASNET Study [0.03%]
循环线粒体细胞因子GDF-15和FGF21与老年人虚弱、肌肉减少症和营养不良的关系：来自FRASNET研究的证据
Sarah Damanti,Clara Sciorati,Rebecca De Lorenzo et al.
Sarah Damanti et al.
Background: Mitochondria-derived GDF15 and FGF21, known as mitokines, are emerging biomarkers of metabolic stress and aging-related decline. Their roles in energy balance, inflammation, and muscle metabolism suggest poten...
An atlas of age- and sex-related volumetric alterations of grey matter in subcortical regions: the case of 46,111 UK Biobank participants [0.03%]
基于46111名英国生物库(UK Biobank)参与者的皮层下区域灰质年龄和性别变化的图谱分析
Fatemeh Tabassi Mofrad,Chris Patrick Pflanz,John Gallacher
Fatemeh Tabassi Mofrad
Ageing is typically accompanied by neuroanatomical changes in brain structure, making it crucial to distinguish normal age-related alterations from pathological ones. Despite this importance, a standardized benchmark for identifying abnorma...
Diminished CEACAM1 level plays a critical role in age-related hepatic fibrosis [0.03%]
CEACAM1水平降低在年龄相关性肝纤维化中起关键作用
Sobia Zaidi,Suman Asalla,Raziyeh Abdolahipour et al.
Sobia Zaidi et al.
Background: Hepatic fibrosis increases with aging, but its physiological progression and underlying mechanisms remain poorly defined. Given that CEACAM1 repression causes metabolic dysfunction and liver injury, the curren...
Linking Nutrition and Aging: a Cross-Domain Analysis of Mediterranean Diet Adhesion Screener Components [0.03%]
营养与衰老的关联：地中海饮食筛查表维度的跨领域分析
Fatma Hastaoglu,Sonia de Pascual-Teresa
Fatma Hastaoglu
This study explores the scientific landscape linking the Mediterranean Diet Adherence Screener (MEDAS) to aging-related health outcomes through a comprehensive bibliometric and scoping review approach. Given the increasing prevalence of chr...
Morin enhances healthspan and neuroprotection in Caenorhabditis elegans via mitochondrial stress adaptation [0.03%]
毛蕊花提取物通过线粒体压力适应提高秀丽隐杆线虫的健康寿命和神经保护作用
Yong-Ha Jo,Hyun-Ok Song,Dong-Sung Lee et al.
Yong-Ha Jo et al.
Morin, a dietary flavonoid with antioxidant and metabolic activity, promotes healthy ageing in Caenorhabditis elegans. Morin extended lifespan by ~18% and alleviated age-related decline in neuronal integrity, locomotion, learning and memory...
lncRNA EPB41L4A-AS1: A promising therapeutic target for aging and age-related diseases [0.03%]
长链非编码RNA EPB41L4A-AS1：抗衰老和年龄相关疾病的潜在治疗靶点
Minghui Li,Tianzi Li,Xufei Zhang et al.
Minghui Li et al.
Aging is a natural biological process characterized by progressive cellular and functional decline, significantly increasing susceptibility to age-related diseases. Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regu...
The Stress-Responsive Cytokine GDF-15 and Sarcopenia: A Systematic Review and Meta-Analysis on Aging Muscle Decline [0.03%]
应激反应细胞因子GDF-15与少肌症：系统回顾和meta分析在衰老肌肉衰退中的作用
Mario Virgilio Papa,Chiara Ceolin,Francesco Boschele et al.
Mario Virgilio Papa et al.
Background: Given the increasing interest for Growth Differentiation Factor-15 (GDF-15) in muscle decline, this study aims to evaluate the association between circulating levels of GDF-15 and muscle mass and sarcopenia th...
Clinical Data-Driven Classification of Pre-Frailty Reveals Sex-Specific Patterns - Data from the Berlin Aging Study II (BASE-II) [0.03%]
基于临床数据的前期衰弱分类揭示了性别特异性模式——源于柏林老龄化研究第二部分（BASE-II）的数据
Jeff Didier,Sébastien De Landtsheer,Maria Pires Pacheco et al.
Jeff Didier et al.
Frailty is a geriatric condition with multidimensional consequences that strongly affect older adults' quality of life. The lack of a universal standard to describe, diagnose, and treat frailty further complicates this situation. Nowadays, ...
Human astrocytes from healthy individuals and Alzheimer's patients respond differently to Aβ1-42 oligomers, triggering distinct paths of reactivity and senescence [0.03%]
来自健康个体和阿尔茨海默病患者的星形胶质细胞对Aβ1-42低聚物的反应不同，触发了不同的活性和衰老路径
Sara Ristori,Gianmarco Bertoni,Alessandra Bigi et al.
Sara Ristori et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by cognitive decline, amyloid-β (Aβ) plaques, and neurofibrillary tangles. Aβ1-42 oligomers exert neurotoxic and pro-inflammatory effects. Astrocytes maintain brain h...
Increased mTOR Signaling Secondary to a Human ILK Missense Variant Inhibits Nephrogenesis with Decreased Metabolism [0.03%]
人类ILK错义突变引起的mTOR信号增加会降低代谢并抑制肾原基形成
Xiangyue Hu,Dana Kablawi,Wout F J Feitz et al.
Xiangyue Hu et al.
Nephrogenesis is critical to mammalian kidney function throughout life. Decreased nephron formation, an embryonic process dependent on ureteric-mesenchymal tissue interactions, is a fundamental feature of Congenital Anomalies of the Kidney ...