The impact of sleep and exercise on brain atrophy in mild cognitive impairment [0.03%]
睡眠和运动对轻度认知障碍患者脑萎缩的影响
Maamoon Mian,Jihane Tahiri,Saadeddine Habbal et al.
Maamoon Mian et al.
Chronic sleep deprivation and lack of physical exercise may have detrimental effects on overall health, particularly in terms of brain health, with significant implications for cognitive function and well-being. This review explores the imp...
Aberrant expression of messenger and small noncoding RNAomes in aged skin of rats [0.03%]
大鼠老化皮肤中信息和小非编码RNA组的异常表达
Danyang Zhao,Yu Wang,Chuandong Wang et al.
Danyang Zhao et al.
The exact mechanisms and key functional molecules involved in skin ageing remain largely unknown. Studies linking the expression of messenger RNAs (mRNAs) and small noncoding RNAs (sncRNAs) to skin ageing are limited. In this study, we perf...
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1 [0.03%]
Narciclasine通过抑制骨骼肌特异性神经酰胺合成酶1来介导炎症和代谢相互作用从而对抗血管衰老的保护效应及生物信息学分析
Zhiyi Fang,Linghuan Wang,Yabin Wang et al.
Zhiyi Fang et al.
Objective: The senescence of smooth muscle is one of the independent risk factors in atherosclerosis progression in which the vascular inflammation plays an important role on vascular dysfunction. This study is designed t...
Molecular mechanisms and potential interventions during aging-associated sarcopenia [0.03%]
衰老相关肌肉减少症的分子机制及潜在干预措施
Xiaoqin Luo,Jin Wang,Qingqing Ju et al.
Xiaoqin Luo et al.
Sarcopenia, a common condition observed in the elderly, presenting a significant public health challenge due to its high prevalence, insidious onset and diverse systemic effects. Despite ongoing research, the precise etiology of sarcopenia ...
Jitendra Kumar Chaudhary,Ajay Kumar Danga,Anita Kumari et al.
Jitendra Kumar Chaudhary et al.
Chemokines (chemotactic cytokines) play essential roles in developmental process, immune cell trafficking, inflammation, immunity, angiogenesis, cellular homeostasis, aging, neurodegeneration, and tumorigenesis. Chemokines also modulate res...
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals [0.03%]
单细胞测序分析人类外周血揭示成功衰老个体中高度的免疫反应能力
Yu Wang,Yuxing Zhang,Ge Gong et al.
Yu Wang et al.
Beneficial remodeling of the immune system in successful ageing individuals (centenarians and supercentenarians) is critical for healthy ageing. However, mechanisms for dynamic regulation of immunity during ageing remain unclear. We use sin...
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids [0.03%]
Senolytics可使人源心脏类器官老化的心肌病恢复活力
Mariangela Scalise,Eleonora Cianflone,Claudia Quercia et al.
Mariangela Scalise et al.
Background: Human cardiac organoids closely replicate the architecture and function of the human heart, offering a potential accurate platform for studying cellular and molecular features of aging cardiomyopathy. Senolyti...
Oral frailty indicators and cardio- and cerebrovascular diseases in older age: A systematic review [0.03%]
口腔脆弱指标与老年人的心血管和脑血管疾病：系统评价研究
Vittorio Dibello,Frank Lobbezoo,Francesco Panza et al.
Vittorio Dibello et al.
Oral health indicators may contribute to the oral frailty phenotype, an age-related gradual loss of oral function together with a decline in cognitive and physical functions. The present systematic review synthetized current knowledge on th...
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 - SDF-1 signaling [0.03%]
孕激素暴露与先天性腹壁缺陷：CXCR4-SDF-1信号的参与作用
Martin Bablok,Gabriela Morosan-Puopolo,Imadeldin Yahya et al.
Martin Bablok et al.
Developmental defects of the ventral abdominal wall, such as gastroschisis, have been associated with prenatal stress exposure. To investigate this further, dexamethasone (DEX), a synthetic glucocorticoid, was administered to fertilized chi...
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targets for personalized treatments [0.03%]
综述新兴的人类炎症性肠病(IBD)生物标志物：内皮祖细胞(EPC)及其囊泡作为心血管表现的潜在生物标志物和个性化治疗目标
Carmela Rita Balistreri
Carmela Rita Balistreri
Inflammatory bowel diseases (IBD) are chronic inflammatory and pathological conditions of the gastrointestinal tract, which include two main clinical subtypes: Crohn's disease (CD) and ulcerative colitis (UC). IBDs show an increase in their...