Abhishek Chandra,Robert J Pignolo
Abhishek Chandra
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging [0.03%]
外泌体在衰老过程中介导心血管-代谢和心血管-肾脏疾病的功能意义
Wing Yan Chung,Sabrina Lam,Brooke Pernari et al.
Wing Yan Chung et al.
Aging increases the risk of cardiometabolic and cardiorenal disease and this is associated with cellular dysregulation including oxidative stress, chronic inflammation, insulin resistance and senescence. Extracellular vesicles (EV) facilita...
Targeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAs [0.03%]
靶向心肌细胞自噬：探索MicroRNA的治疗潜力
Amin Javadifar,Masoud Tahani,Sorousha Khayat et al.
Amin Javadifar et al.
Mitophagy, a selective form of autophagy, plays an indispensable role in preserving mitochondrial integrity by eliminating dysfunctional mitochondria, thereby sustaining cellular homeostasis. This process is particularly critical in cardiom...
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review [0.03%]
动物和人类细胞衰老的饮食因素：系统性综述
Lihuan Guan,Kristina Zdantsevich,Elena Sandalova et al.
Lihuan Guan et al.
Background: Cellular senescence (CS) is a hallmark of ageing and age-related diseases. While dietary interventions are often explored to reduce CS, less is known about dietary ingredients that induce it. This study system...
Kalyani Pandya,Annabel Menendez,Mark G MacAskill et al.
Kalyani Pandya et al.
Age and sex exert profound influences on the heart, shaping its structure, function, and susceptibility to disease. Among the myriad of changes driven by age and sex, alterations in the extracellular matrix (ECM), particularly collagen infl...
The combination of GDF15, FGF21, sRAGE and NfL plasma levels can identify frailty in community-dwelling people across old age [0.03%]
GDF15、FGF21、sRAGE和NfL的血浆水平联合可用于识别社区居住老年人中的衰弱状态
Maria Conte,Federica Sevini,Giuseppe Conte et al.
Maria Conte et al.
Frailty is a complex medical condition characterized by decline in physiological functions and global health of older people, representing a strong risk factor for disability, hospitalization, and mortality. The identification of biomarkers...
Elena Carbone,Elisa Fabrizi,Roberto Rivabene et al.
Elena Carbone et al.
Studying aging and risk factors associated with chronic non-communicable diseases is increasingly relevant due to the progressive aging of the global population. Risk factors have focused on diet, physical exercise, cognitive activity, and ...
Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults [0.03%]
基于血浆代谢组揭示口服葡萄糖耐量试验在中年成人中的性别差异响应
C M Donado-Pestana,L Rodrigues,M Rundle et al.
C M Donado-Pestana et al.
Sex is a key determinant of human phenotype, with males and females exhibiting distinct anthropometric and metabolic features that influence disease susceptibility. This study investigated sex-specific metabolic differences in late middle-a...
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections [0.03%]
种间互作与衰老：预测致龄细菌及微生物感染的人源蛋白关键靶标
Yuping Dai,Ni Boussaguet,Jérôme Teulière et al.
Yuping Dai et al.
Bacteria permeate every niche of the human body with major consequences on our health and senescence that have not been fully described. Here, we predict which bacteria and which bacterial proteins could interfere with proteins associated w...
Cyr61 Promotes D-gal-induced Aging C2C12 Cell Fibrosis by Modulating Wnt/β-catenin Signaling Pathways [0.03%]
Cyr61通过调节Wnt/β-catenin信号通路促进D-半乳糖诱导的C2C12细胞纤维化
Xinchen Huang,Xiaoling Kui,Jiyao Ma et al.
Xinchen Huang et al.
Sarcopenia is characterized by age-related muscle mass/function loss and fibrosis. Satellite cell (SC) dysfunction during aging promotes fibrotic transdifferentiation and extracellular matrix (ECM) deposition. Cyr61, a pro-fibrotic matricel...