Gloria Olaso-González,Consuelo Borrás
Gloria Olaso-González
Chemokines are small cytokines that are essential for recruiting immune cells and modulating inflammatory responses. Their expression and activity are tightly regulated by redox homeostasis, which influences cellular signaling and immune fu...
Embryonic stem cell-derived extracellular vesicles alleviate ovarian dysfunction [0.03%]
胚胎干细胞源性外泌体可缓解卵巢功能障碍
Xiang Li,Ru Ma,Mantong Zhao et al.
Xiang Li et al.
Background: Premature ovarian insufficiency (POI) causes irreversible follicular depletion and infertility, and current treatments do not reliably preserve fertility after gonadotoxic chemotherapy. Recent work suggests ex...
Effectiveness of exercise and nutrition interventions for cognitive function in older adults: A systematic review and meta-analysis [0.03%]
运动和营养干预对老年人认知功能的效果：系统评价和荟萃分析
Sergio Castillo-Bernad,Ana Moradell,Alejandro Gómez-Bruton et al.
Sergio Castillo-Bernad et al.
Although life expectancy has increased, the proportion of years lived without disability has not improved at the same rate. This has contributed to the rising prevalence of dementia, which currently affects over 55 million people worldwide....
Curvilinear dose-response association of physical activity with clinically diagnosed stress: Prospective cohort with 74,000 individuals [0.03%]
基于10万个体的前瞻性队列研究：运动与临床诊断压力之间的非线性剂量-反应关系
Lars Louis Andersen,Joaquín Calatayud,Rodrigo Núñez-Cortés et al.
Lars Louis Andersen et al.
This study examined the prospective dose-response association of accelerometer-derived physical activity with clinically diagnosed stress. We included adults aged 40-69 years from the UK Biobank cohort, free of severe disease at baseline, w...
Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds [0.03%]
肌腱稳态和再生：细胞、免疫反应和生物活性化合物的相互作用
Noemi Mencarelli,Simone Carradori,Marialucia Gallorini
Noemi Mencarelli
Tendons are specialized connective tissues that transmit mechanical forces from muscle to bone, ensuring joint stability and efficient locomotion. Their homeostasis and regenerative capacity depend on the interplay between extracellular mat...
Mercedes Grima-Terrén,Megan Rommelfanger,Silvia Campanario et al.
Mercedes Grima-Terrén et al.
Muscle atrophy and functional decline are shared manifestations of aging and neuromuscular pathologies. Deciphering the molecular mechanisms underlying muscle decline in these conditions has been slow, partly due to the difficulties of mole...
IPMK-1 governs C. elegans physiology through ceTOR but lifespan via a distinct IP3-dependent pathway [0.03%]
IPMK-1通过ceTOR调节秀丽隐杆线虫的生理活动，但通过一种独立的IP3依赖性通路调节寿命
Xuan-Xuan He,Qiong Huang,Xin-Tian Yu et al.
Xuan-Xuan He et al.
Inositol-polyphosphate multikinase (IPMK) is a pleiotropic enzyme essential for metabolic homeostasis, cancer, neural function, and development. While mammalian IPMK is well-characterized, the systemic integration of its signaling outputs -...
Adriana Baca,Judith Félix,Estefanía Díaz-Del Cerro et al.
Adriana Baca et al.
The gut microbiota communicates with the homeostatic systems (nervous, immune, and endocrine). As we age, there is an increase in oxidative stress, which can deteriorate these systems, the microbiota, and the communication between them. It ...
NAD⁺ as a Central Metabolic Hub Regulating the Hallmarks of Aging: Mechanisms and Therapeutic Implications [0.03%]
NAD+作为调节衰老特征的中枢代谢节点：机制和治疗意义
Zerong Pei,Fengni Liang,Xuemei Wang et al.
Zerong Pei et al.
The increasing global burden of age-related diseases necessitates interventions that target the unified biological processes of aging, as outlined by the expanding framework of fourteen interconnected hallmarks. This review establishes nico...
Mitochondrial quality in aging and neurodegeneration: The emerging role of mitochondria-derived vesicles [0.03%]
衰老和神经退行性病变中的线粒体质量：线粒体衍生囊泡的作用不容忽视
Emanuele Marzetti,Rosa Di Lorenzo,Riccardo Calvani et al.
Emanuele Marzetti et al.
Mitochondria are central to cellular energy metabolism, redox balance, and signaling, and their integrity is maintained by a multilayered mitochondrial quality control (MQC) system. This system includes proteostasis, dynamics, biogenesis, a...