PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts [0.03%]
PCSK9通过诱导心脏成纤维细胞向成骨细胞分化促进老年相关的心脏钙化现象
Gang Liu,Qiuya Cai,Lin Ye et al.
Gang Liu et al.
Cardiac calcification is an age-associated pathological process that contributes to cardiac dysfunction, arrhythmia, and sudden cardiac death, yet its underlying mechanisms remain unclear. Cardiac fibroblasts (CFs) have emerged as key media...
"Distinct Post-Infectious TLR2 Immune Remodeling in COVID-19-Recovered Centenarians" [0.03%]
"百岁新冠肺炎康复者特异的病毒感染后TLR2免疫重塑"
Anna Julia Pietrobon,Luana De Mendonça Oliveira,João Paulo Limongi França Guilherme et al.
Anna Julia Pietrobon et al.
Exceptional longevity has increasingly been recognized as a distinct biological state associated with unique immune and inflammatory profiles. However, the innate immune characteristics associated with extreme aging, particularly following ...
Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice [0.03%]
干燥综合征小鼠模型下颌下腺中与衰老相关的三级淋巴组织结构的形成
Hiroshi Nishiura,Kiyoshi Matsui,Naoto Azuma et al.
Hiroshi Nishiura et al.
We discovered a Sjögren's disease (SjD)-like state in the programmed cell death 1+ (PD-1⁺) niches of the spleen and submandibular glands of 36-week-old female Nishiura (NI) mice, characterized by the formation of tertiary lymphoid structu...
Aging-driven reprogramming of CD34⁺ hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications [0.03%]
衰老驱动的CD34⁺造血干细胞重编程在白血病发生中的机制及治疗意义
Surya Nath Pandey,Muhammad Afzal,A Rekha et al.
Surya Nath Pandey et al.
Aging is a major driver of hematological impairment and a significant risk factor for hematologic malignancies. CD34⁺ hematopoietic stem and progenitor cells (HSPCs) represent a critical cellular compartment in which age-related changes co...
The Hippo-YAP/TAZ axis: A central signaling hub integrating diverse cues to regulate cellular senescence [0.03%]
河马素-YAP/TAZ轴：一个调节细胞衰老的中心信号转导节点
Shiqing Tan,Xueqin Huang,Junyao Li et al.
Shiqing Tan et al.
Cellular senescence, an irreversible state of cell cycle arrest, has emerged as a critical contributor to tissue dysfunction and organismal aging, and is implicated in a range of pathological conditions including atherosclerosis, tissue fib...
Alternative splicing in Alzheimer's disease: Driver, modifier, or consequence of neurodegeneration [0.03%]
阿尔茨海默病中的选择性剪接：神经退行性病变的驱动者、修饰因子或伴随现象？
Gonzalo Emiliano Aranda-Abreu,Fausto Rojas-Durán,María Elena Hernández-Aguilar et al.
Gonzalo Emiliano Aranda-Abreu et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder in which the molecular mechanisms driving onset and progression remain incompletely understood. Emerging evidence highlights RNA splicing as a central regulatory axis shaping ...
Gut microbiota profiling in patients with bone fragility fracture and severe osteoarthritis: a pilot study [0.03%]
骨质脆弱骨折和重度骨关节炎患者肠道微生物组特征分析的试点研究
Giorgia Borciani,Gabriele Conti,Alberto Di Martino et al.
Giorgia Borciani et al.
Over the past decade, much attention has been directed towards the gut microbiota (GM) as a contributing factor to a wide range of diseases, especially in the aging population. In this study, we analyzed the GM of elderly patients with frag...
Senolytics Ameliorate Cognitive Decline in D-Galactose-Induced Aging Mice by Inhibiting Astrocytic Cholesterol Accumulation [0.03%]
Senolytics通过抑制星形胶质细胞胆固醇积累改善D-半乳糖诱导的衰老小鼠认知衰退
Lulin Nie,Wei Wu,Chenyuan Hu et al.
Lulin Nie et al.
Cellular senescence plays a crucial role in brain aging and the decline of cognitive abilities. Although senolytic treatments, particularly the combination of dasatinib and quercetin (D+Q), show potential for improving cognition, the specif...
Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster [0.03%]
果蝇神经元Syndecan减少可调节年龄和性别特异性睡眠结构及代谢重塑的改变
Victoria G Faber,Denise Vecchie&#x;,Francesco De Rango et al.
Victoria G Faber et al.
Age-related deterioration of sleep is a conserved feature of aging and is closely associated with metabolic dysregulation and neurodegeneration. However, the molecular mechanisms that sustain sleep stability across the lifespan remain incom...
Cell-specific energy crisis in the ageing brain: Mitochondrial dynamics drives neuron-glia metabolic uncoupling and neurodegeneration [0.03%]
衰老大脑中的细胞特异性能量危机：线粒体动力学驱动神经胶质代谢脱耦和神经退行性病变
Kai Wang,Yongchao Liu,Haojia Zhang et al.
Kai Wang et al.
Ageing is the primary risk factor for neurodegeneration and age-related cognitive decline, which is increasingly recognised as a systemic collapse of metabolic crosstalk between neurons and glial cells in the brain. This narrative review el...