lncRNA EPB41L4A-AS1: A promising therapeutic target for aging and age-related diseases [0.03%]
长链非编码RNA EPB41L4A-AS1：抗衰老和年龄相关疾病的潜在治疗靶点
Minghui Li,Tianzi Li,Xufei Zhang et al.
Minghui Li et al.
Aging is a natural biological process characterized by progressive cellular and functional decline, significantly increasing susceptibility to age-related diseases. Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regu...
The Stress-Responsive Cytokine GDF-15 and Sarcopenia: A Systematic Review and Meta-Analysis on Aging Muscle Decline [0.03%]
应激反应细胞因子GDF-15与少肌症：系统回顾和meta分析在衰老肌肉衰退中的作用
Mario Virgilio Papa,Chiara Ceolin,Francesco Boschele et al.
Mario Virgilio Papa et al.
Background: Given the increasing interest for Growth Differentiation Factor-15 (GDF-15) in muscle decline, this study aims to evaluate the association between circulating levels of GDF-15 and muscle mass and sarcopenia th...
Clinical Data-Driven Classification of Pre-Frailty Reveals Sex-Specific Patterns - Data from the Berlin Aging Study II (BASE-II) [0.03%]
基于临床数据的前期衰弱分类揭示了性别特异性模式——源于柏林老龄化研究第二部分（BASE-II）的数据
Jeff Didier,Sébastien De Landtsheer,Maria Pires Pacheco et al.
Jeff Didier et al.
Frailty is a geriatric condition with multidimensional consequences that strongly affect older adults' quality of life. The lack of a universal standard to describe, diagnose, and treat frailty further complicates this situation. Nowadays, ...
Human astrocytes from healthy individuals and Alzheimer's patients respond differently to Aβ1-42 oligomers, triggering distinct paths of reactivity and senescence [0.03%]
来自健康个体和阿尔茨海默病患者的星形胶质细胞对Aβ1-42低聚物的反应不同，触发了不同的活性和衰老路径
Sara Ristori,Gianmarco Bertoni,Alessandra Bigi et al.
Sara Ristori et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by cognitive decline, amyloid-β (Aβ) plaques, and neurofibrillary tangles. Aβ1-42 oligomers exert neurotoxic and pro-inflammatory effects. Astrocytes maintain brain h...
Increased mTOR Signaling Secondary to a Human ILK Missense Variant Inhibits Nephrogenesis with Decreased Metabolism [0.03%]
人类ILK错义突变引起的mTOR信号增加会降低代谢并抑制肾原基形成
Xiangyue Hu,Dana Kablawi,Wout F J Feitz et al.
Xiangyue Hu et al.
Nephrogenesis is critical to mammalian kidney function throughout life. Decreased nephron formation, an embryonic process dependent on ureteric-mesenchymal tissue interactions, is a fundamental feature of Congenital Anomalies of the Kidney ...
Disentangling tau, glymphatic dysfunction and astrocytic activation in amyloid-positive Alzheimer's disease [0.03%]
解开淀粉样蛋白阳性的阿尔茨海默病中的tau、glymphatic功能障碍和星形胶质细胞活化的关系
Hsin-I Chang,Shih-Wen Chen,Shu-Hua Huang et al.
Hsin-I Chang et al.
Alzheimer's disease (AD) features tau pathology, neurodegeneration, and cognitive decline. Dysfunction of the glymphatic system, which clears pathological proteins, and astrocytic activation may exacerbate neurodegeneration. We investigated...
Emanuele Marzetti,Riccardo Calvani,Helio José Coelho-Junior et al.
Emanuele Marzetti et al.
Age-related skeletal muscle decline is a major contributor to frailty, functional impairment, and loss of independence in advanced age. This process is characterized by selective atrophy of type II fibers, impaired excitation-contraction co...
Kun Li,Xiaolin Qiu,Qiqi Yang et al.
Kun Li et al.
Alzheimer's disease (AD) is one of the most prevalent diseases in the older population. AD causes progressive cognitive and behavioral impairment, but current treatments are unable to slow or prevent the progression of this disease. Thus, i...
ABI3BP Deficiency Alleviates Ang II-Induced VSMC Senescence through the NRF2 Signalling Pathway [0.03%]
ABl3BP缺陷通过NRF2信号通路缓解Ang II诱导的血管平滑肌细胞衰老
Aiqiu Mao,Qiang Tu,Huaqiang Xie et al.
Aiqiu Mao et al.
Vascular aging is a critical independent risk factor for cardiovascular disease (CVD), yet its precise molecular mechanisms remain poorly understood. In this study, we generated an ABI3BP knockout mouse to investigate the role of ABI3BP def...
DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis [0.03%]
由FOXF1-EZH2轴调节的DKK3通过作用于肾小管上皮细胞衰老来触发肾小球内皮细胞铁死亡从而参与肾脏纤维化
Huiling Cao,Yanxia Chen,Jinjing Huang et al.
Huiling Cao et al.
Chronic kidney disease (CKD) can be accelerated by renal fibrosis. Dickkopf-3 (DKK3) plays a role in regulating renal fibrosis, while tubular cell senescence contributes to fibrosis development. Here, the role and mechanism of DKK3 on senes...