Beyond Neurodegeneration: Systemic Confounders of Blood Neurofilament Light Chain in Aging and Their Implications for Neurological Biomarker Interpretation [0.03%]
超越神经退行性病变：衰老过程中血液神經絲輕鏈的全身混杂因素及其对神经系统生物标志物解读的意义
Giulia Bonvini,Davide Sattin,Nunzio Iraci et al.
Giulia Bonvini et al.
Unlike younger populations, older individuals often live with multiple systemic conditions that may influence neurofilament light chain (NfL) levels beyond true neuroaxonal injury, complicating its interpretation as a pure marker of neurona...
Enhancing the Anti-Aging Capacity of hUC-MSCs via NMN Co-Treatment in D-Galactose-Induced Mice and Cellular Senescence Models [0.03%]
NMN协同治疗提升人脐带间充质干细胞抗衰老能力的机制研究
Kangrui Liu,Yiming Cao,Yizhou Gu et al.
Kangrui Liu et al.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have emerged as a promising therapeutic option for anti-aging therapy. However, the aging microenvironment can induce oxidative stress and senescence in transplanted hUC-MSCs, t...
ABO blood groups and ageing-related outcomes: Insights from a narrative review [0.03%]
ABO血型与衰老相关结局：叙事性综述的启示
Carmela Rita Balistreri,Alessia Di Salvo,Chiara Motisi et al.
Carmela Rita Balistreri et al.
The identification of reliable biomarkers of ageing represents a major challenge in biomedical research, particularly in the context of increasing life expectancy and the growing burden of chronic diseases. Among potential candidates, the A...
Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species [0.03%]
寿命延长的生物学极限：跨物种从途径作用力到系统级缓冲的转变证据
Denisa Fv Pirscoveanu,Mihai-Cristian Papa,Britta Kaltwasser et al.
Denisa Fv Pirscoveanu et al.
Interventions targeting conserved aging pathways can markedly extend lifespan in model organisms, yet their efficacy declines with increasing organismal complexity. While this phenomenon is well documented, the underlying constraints remain...
Blood Biochemistry Age Clock - an interpretable estimate of biological age and predictor of all-cause-mortality derived from routinely ordered blood biomarkers [0.03%]
血液生化年龄时钟——一种可解释的生物学年龄估算和全因死亡率预测指标，源自常规订购的血液生物标志物
Julij Šelb,Leon Deutsch,Matej Červek et al.
Julij Šelb et al.
"Omic" aging clocks(ACs) represent an established predictor of biological-age(BA)/all-cause-mortality(ACM); however, they are expensive and lack interpretability/explainability. We developed a Blood-Biochemistry Age Clock(BBAC) composed of ...
Parental factors, prenatal air exposures, and adolescent trauma are associated with telomere length in early adulthood: Evidence from a UK longitudinal birth cohort [0.03%]
来自英国纵向出生队列的证据表明父母因素、孕期空气暴露和青少年创伤与成年早期端粒长度有关
Tsz Yan Wong,Alexandra C Gillett,Rodrigo R R Duarte et al.
Tsz Yan Wong et al.
Leukocyte telomere length (LTL) is a biomarker of cellular ageing, with shorter telomeres linked to increased risk of age-related diseases. Although adverse early-life environments have been associated with shorter LTL in later adulthood, i...
Saba Khatatneh,Csaba Sőti,Milán Somogyvári
Saba Khatatneh
Heat shock transcription factor HSF1 maintains proteome integrity via the induction of heat shock proteins. Here, we provide a comprehensive overview on the structure, function and regulation of HSF1 in multiple organisms. We summarize the ...
Circulating elastin fragments drive systemic aging: Where do pro-aging elastin fragments come from? A mini-review [0.03%]
循环弹性蛋白片段驱动全身衰老：促衰老弹性蛋白片段来自何方？一篇小型综述文章
Taihao Quan
Taihao Quan
Circulating elastin fragments have emerged as potent mediators of inflammaging and systemic aging, yet a fundamental question persists: which anatomical compartments serve as the primary sources of these fragments during aging? Elastin is a...
Human sex-specific hormone effects on cerebrovascular health in males and females [0.03%]
人类性别特异性激素对男性和女性脑血管健康的影响
Brittany Intzandt,Zacharie Potvin-Jutras,Claudine J Gauthier
Brittany Intzandt
Circulating sex hormone levels decrease in aging, influencing cerebrovascular health. Estradiol has been shown to support female vascular and brain health, though its effects across the menopausal transition remain unknown. Similarly, the i...
HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan [0.03%]
HTZ-1/H2A.Z表达维持调节秀丽隐杆线虫寿命的转录程序
Beijia Xie,Enzo Scifo,Ioanna-Maria Menegatou et al.
Beijia Xie et al.
Animal lifespan depends on coordinated gene expression networks that regulate metabolic adaptation, proteostasis, and stress resilience in response to environmental challenges. Histone variants are key regulators of chromatin dynamics, orch...