Jee Hee Yoon,Yun Haeng Lee,Sekyung Oh et al.
Jee Hee Yoon et al.
One of the main factors contributing to aging is reactive oxygen species (ROS), which are produced by dysfunctional mitochondria. Reducing ROS generation is considered an essential treatment for senescence, but no effective treatment has be...
Senescent cancer-associated fibroblasts in cancer progression: From formation to therapeutic opportunities [0.03%]
癌相关成纤维细胞的衰老在癌症进展中的作用：从形成到治疗机遇
Yingying Feng,Xiaochen Zhi,Ting Xiao et al.
Yingying Feng et al.
Cancer-associated fibroblasts (CAFs) are a key cellular component of the tumor microenvironment (TME), which comprises distinct subtypes, each exhibiting unique and significant roles in cancer development. Senescent cancer-associated fibrob...
Dietary restriction mitigates cognitive impairments in a mouse model of SCA19/22 [0.03%]
饮食限制可缓解SCA19/22小鼠模型的认知障碍
Cheng-Yun Ma,Sheng-Rong Yeh,Yi-Hsuan Huang et al.
Cheng-Yun Ma et al.
Spinocerebellar ataxia types 19 and 22 (SCA19/22) are neurodegenerative disorders caused by mutations in KCND3 (potassium voltage-gated channel subfamily D member 3). Previous studies have developed Kcnd3 F227del knock-in (KI) mice that suc...
SRC Suppression Attenuates Vascular Aging by Activating FUNDC1-Dependent Mitophagy [0.03%]
SRC抑制通过激活FUNDC1依赖性线粒体自噬来缓解血管衰老
Linghuan Wang,Yan Ma,Tianhu Wang et al.
Linghuan Wang et al.
Vascular smooth muscle cell senescence contributes critically to vascular remodeling and atherosclerosis, with mitochondrial dysfunction and impaired mitophagy recognized as major contributors. SRC, a stress-responsive tyrosine kinase, has ...
Inflammatory and genetic mechanisms mediate the association between frailty and incident atopic dermatitis in middle-aged and elderly adults [0.03%]
炎症和遗传机制介导了中老年人衰弱与特应性皮炎发病之间的关系
Peizhi Deng,Siyu Tang,Jinron Zeng et al.
Peizhi Deng et al.
Frailty is linked to many chronic conditions, but its relationship with atopic dermatitis (AD) remains insufficiently defined. We assessed whether frailty predisposes to incident AD and explored inflammatory and genetic mechanisms. Baseline...
Apelin-13 activates TFEB-mediated autophagy via AMPK to attenuate senescence and pyroptosis in nucleus pulposus cells during intervertebral disc degeneration [0.03%]
阿皮林通过AMPK激活TFEB介导的自噬减轻椎间盘细胞衰老和焦亡以治疗椎间盘退变性疾病
Yuhang Gong,Jie Xiang,Ben Wang et al.
Yuhang Gong et al.
Intervertebral disc degeneration (IDD) is an aging-associated disorder driven by chronic inflammation. Impaired autophagy is a hallmark of disc aging, but its upstream regulation remains unclear. Here, we identify Apelin-13 (APL13) as an en...
How to measure, analyze, and interpret age-related changes in Caenorhabditis elegans: Lessons for mechanistic and evolutionary theories of aging [0.03%]
如何在秀丽隐杆线虫中测量、分析和解读与年龄相关的改变：机制及衰老进化理论的启示
Zuzana Kocsisova,Brian M Egan,Andrea Scharf et al.
Zuzana Kocsisova et al.
Aging is characterized by progressive degenerative changes in tissue organization and function, some of which increase the probability of mortality. Major goals of aging research are to elucidate the series of events that cause degenerative...
Mathew Shuen,Regis R Lamberts,Sean Coffey et al.
Mathew Shuen et al.
Ageing populations present substantial healthcare challenges, with cardiovascular disease (CVD) remaining the predominant cause of morbidity and mortality globally. Cardiac ageing is characterised by progressive cellular and molecular chang...
Qiliang Yin,Yan Zhang,Xingcheng Yi et al.
Qiliang Yin et al.
It is generally believed that hematopoietic aging is a major driver or contributor of human aging. The hematopoietic system undergoes physiological or pathological changes with aging, which drive or contribute to the aging of almost all sys...
Christopher Hofmann,Hartmut Geiger
Christopher Hofmann
The colon is one of the gastrointestinal organs most profoundly affected by aging. Recent advances in our understanding of both colonic physiology and the general mechanisms of aging have significantly expanded our knowledge of the types an...