NAD⁺ as a Central Metabolic Hub Regulating the Hallmarks of Aging: Mechanisms and Therapeutic Implications [0.03%]
NAD+作为调节衰老特征的中枢代谢节点：机制和治疗意义
Zerong Pei,Fengni Liang,Xuemei Wang et al.
Zerong Pei et al.
The increasing global burden of age-related diseases necessitates interventions that target the unified biological processes of aging, as outlined by the expanding framework of fourteen interconnected hallmarks. This review establishes nico...
Mitochondrial quality in aging and neurodegeneration: The emerging role of mitochondria-derived vesicles [0.03%]
衰老和神经退行性病变中的线粒体质量：线粒体衍生囊泡的作用不容忽视
Emanuele Marzetti,Rosa Di Lorenzo,Riccardo Calvani et al.
Emanuele Marzetti et al.
Mitochondria are central to cellular energy metabolism, redox balance, and signaling, and their integrity is maintained by a multilayered mitochondrial quality control (MQC) system. This system includes proteostasis, dynamics, biogenesis, a...
So-Mi Kang,Soyoung Park,Tae-Gyun Woo et al.
So-Mi Kang et al.
Progerin, a truncated lamin A isoform generated by cryptic LMNA splicing, is the pathogenic driver of Hutchinson-Gilford Progeria Syndrome (HGPS) and has been implicated as a putative marker in natural ageing. Low-level progerin arises in n...
Blood levels of immune-related biomarkers and future risk for prefrailty/frailty: The prospective ATTICA sub-study 2002-2024 [0.03%]
免疫相关生物标志物的血浆水平与未来衰弱发生的前瞻性风险：来自ATTICA子研究（2002年至2024年）的数据
Sofia-Panagiota Giannakopoulou,Danai Sgouropoulou,Fotios Barkas et al.
Sofia-Panagiota Giannakopoulou et al.
Background: Given that low-grade inflammation is implicated in the pathophysiology of age-related frailty, we tested the hypothesis that individual blood biomarkers are associated with the risk of developing frailty in la...
Inflammaging in geriatric liver disease: Mechanistic insights and therapeutic frontiers [0.03%]
衰老相关肝脏疾病的炎症老化机制及治疗新策略
Xu Xu,Xiao Wei,Xiaolin Yang et al.
Xu Xu et al.
The rising prevalence of chronic liver disease in older adults necessitates a deeper understanding of the mechanisms driving hepatic vulnerability to aging. This review proposes a mechanistic framework positioning hepatic "inflammaging"-a c...
Use of potential gerotherapeutic drugs and mortality in geriatric rehabilitation inpatients: RESORT [0.03%]
潜在增龄治疗药物的使用与老年康复住院患者死亡率的关系：RESORT研究
Weilan Wang,Lihuan Guan,Ajla Hodzic Kuerec et al.
Weilan Wang et al.
Repurposed existing drugs could serve as promising gerotherapeutic agents. However, their effectiveness in improving clinical outcomes among geriatric rehabilitation inpatients remains unclear. This study investigated the longitudinal obser...
Antiretroviral raltegravir, a selective human immunodeficiency virus type 1 integrase inhibitor, shows anti-Alzheimer's potential against amyloid-beta1-42-induced neurodegeneration [0.03%]
抗艾滋病药物Raltegravir显示出对抗淀粉样蛋白β1-42诱导的神经退行性疾病的潜在抗阿兹海默症效果
Mehdi Alami,Hicham Berrougui,Kaoutar Boumezough et al.
Mehdi Alami et al.
There is growing evidence supporting the potential role of microbial infections in the aetiology of Alzheimer's disease (AD) and the protective role of anti-viral therapies. However, not much is known about the molecular mechanisms underlyi...
Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging [0.03%]
二甲双胍诱导的长寿与酵母菌型衰老中的逆转录转座子动力学有关
Jimena Meneses-Plascencia,Ericka Moreno-Méndez,Diana Ascencio et al.
Jimena Meneses-Plascencia et al.
The widely used antidiabetic drug metformin promotes longevity across diverse model organisms, from yeast to primates, yet the cellular mechanisms by which it acts are not fully resolved. Here, we use high-resolution genetic profiling to de...
Ayesha Fauzi,Chloe Zi En Wong,Phoebe Yon Ern Tee et al.
Ayesha Fauzi et al.
Aging progressively alters stem cell function, undermining tissue homeostasis and contributing to age-related diseases. This review synthesises current evidence on the molecular and cellular mechanisms that drive stem cell aging, with empha...
Jee Hee Yoon,Yun Haeng Lee,Sekyung Oh et al.
Jee Hee Yoon et al.
One of the main factors contributing to aging is reactive oxygen species (ROS), which are produced by dysfunctional mitochondria. Reducing ROS generation is considered an essential treatment for senescence, but no effective treatment has be...