Conjugated linoleic acid isomers modulate protein expression profile in rat hepatocytes [0.03%]
共轭亚油酸异构体对大鼠肝细胞蛋白质表达谱的调节作用
E Rossi,L Della Casa,S Piana et al.
E Rossi et al.
Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid, which has been recently proven to be effective in reducing body fat mass, but brings as a side effect, the liver enlargement due to an increased lipid content. The in vivo lipo...
The role of nuclear receptors in the kidney in obesity and metabolic syndrome [0.03%]
核受体在肥胖和代谢综合征中的肾脏作用
Claudia Tovar-Palacio,Nimbe Torres,Andrea Diaz-Villaseñor et al.
Claudia Tovar-Palacio et al.
Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of renal physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes, including kidney lipid metabolism, ...
Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors [0.03%]
大豆蛋白 dietary soy protein诱导肥胖zucker雄性大鼠肝脏脂质合成酶表达及抑制肝steatosis作用的研究
Reza Hakkak,Ahmed Al-Dwairi,George J Fuchs et al.
Reza Hakkak et al.
Fatty liver is associated with obesity and breast cancer. We used an obese rat model of mammary cancer to examine whether hepatosteatosis is modifiable by diet and associated with altered expression of hepatic lipogenic enzyme genes, thyroi...
Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype [0.03%]
Equol产生者和非产生者的流行病学特征及Equol表型的全基因组关联研究
Kyung-Won Hong,Kwang-Pil Ko,Younjhin Ahn et al.
Kyung-Won Hong et al.
Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equol production on health in Korea...
Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams [0.03%]
铜缺乏大鼠幼鼠转铁蛋白血症与他佩辛表达受抑有关但母鼠无关
Margaret Broderius,Elise Mostad,Joseph R Prohaska
Margaret Broderius
Copper deficiency leads to anemia but the mechanism is unknown. Copper deficiency also leads to hypoferremia, which may limit erythropoiesis. The hypoferremia may be due to limited function of multicopper oxidases (MCO) hephaestin in entero...
Daiva E Nielsen,Ahmed El-Sohemy
Daiva E Nielsen
Personal genetic information has become increasingly accessible to the public as a result of direct-to-consumer (DTC) genetic tests; however, concerns have been raised over their value and potential risks. We compared the effects of providi...
Influence of different CLA isomers on insulin resistance and adipocytokines in pre-diabetic, middle-aged men with PPARγ2 Pro12Ala polymorphism [0.03%]
不同CLA异构体对PPARγ2 Pro12Ala多态性前期糖尿病中年男性胰岛素抵抗和脂肪细胞激素的影响
Diana Rubin,Julia Herrmann,Daniela Much et al.
Diana Rubin et al.
Conjugated linoleic acids (CLAs) are natural PPARγ ligands, which showed conflicting effects on metabolism in humans. We examined metabolic effects of different isomers of CLA in subjects with PPARγ2 Pro12Ala polymorphisms. A total of 35 ...
Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil [0.03%]
ω-3多不饱和脂肪酸（PUFAS）油对雷特综合征的部分治疗作用
Claudio De Felice,Cinzia Signorini,Thierry Durand et al.
Claudio De Felice et al.
Evidence of enhanced oxidative stress (O.S.) and lipid peroxidation has been reported in patients with Rett syndrome (RTT), a relatively rare neurodevelopmental disorder progressing in 4-stages, and mainly caused by loss-of-function mutatio...
Evaluation of multiple variate selection methods from a biological perspective: a nutrigenomics case study [0.03%]
从生物学角度评估多种多变量选择方法：营养基因组学的一个案例研究
Henri S Tapp,Marijana Radonjic,E Kate Kemsley et al.
Henri S Tapp et al.
Genomics-based technologies produce large amounts of data. To interpret the results and identify the most important variates related to phenotypes of interest, various multivariate regression and variate selection methods are used. Although...