Anti-inflammatory potential of plant-derived extracellular vesicles from Solanum nigrum L. integrated in gelatine-dopamine hydrogel on RAW 264.7 and MC3T3 cells [0.03%]
植物来源的溶胶-凝胶中Solanum nigrum L.外泌体的抗炎潜力研究
Anggraini Barlian,Tasya Fediarisa,Aida Fitri Kamila et al.
Anggraini Barlian et al.
Background and purpose: Plant-derived extracellular vesicles (PDEV) from Solanum nigrum L. fruit show promise as a cell-free regenerative and inflammatory therapy for bone defects due to their anti-inflammatory properties...
Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [0.03%]
七氢氧化麻精碱和麻精碱的联合作用动力学模型的贝叶斯推断法研究
Dion Notario,Untung Gunawan,Pretty Falena Atmanda Kambira et al.
Dion Notario et al.
Background and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrati...
Schiff base metal complexes as emerging therapeutics against antimicrobial-resistant skin pathogens [0.03%]
施夫碱金属配合物作为抗耐药性皮肤病原菌的新兴药物治疗方法
Parami Sinhapitiya,Samawansha Tennakoon,Isuri A D K Weeraratne
Parami Sinhapitiya
Background and purpose: The development of antimicrobial resistance reduces the efficacy of antimicrobial agents and poses a significant challenge to treat skin diseases. Many scientists, researchers, and pharmaceutical c...
Poly(lactic-co-glycolic acid) nanoparticles and microparticles for peptide delivery: release mechanisms and controlling factors [0.03%]
聚乳酸-乙交酯纳米颗粒和微粒的蛋白多肽药物递送体系：释放机制及影响因素分析
Mohammadmahdi Eshaghi,Marzieh Dehghani,Azam Abedi et al.
Mohammadmahdi Eshaghi et al.
Background and purpose: Therapeutic peptides offer high potency but are limited by rapid degradation, poor bioavailability, and the need for frequent dosing. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles and micropar...
Imipramine solubility-pH profiles: self-aggregation vs. common-ion effect [0.03%]
阿米替林的溶解度-PH曲线：自聚集与同离子效应
Olivera S Marković,Miloš P Pešić,Alex Avdeef et al.
Olivera S Marković et al.
Background and purpose: The pH-dependent solubility of imipramine, a tricyclic antidepressant, and its hydrochloride salt was investigated in phosphate buffers and chloride-containing aqueous media using the pH-ramp shake...
Potential effect of nanoformulated iota carrageenan in Aβ1-42 disaggregation: an in vitro, in vivo and in silico study [0.03%]
纳米包封的希腊角叉菜胶治疗Aβ1-42解聚的潜在效果：体外、体内和分子对接研究
Saranya Udayakumar,Sanjay Kisan Metkar,Koyeli Girigoswami et al.
Saranya Udayakumar et al.
Background and purpose: Alzheimer's disease is the primary contributor to neurodegenerative conditions. These pathologies are identified by the deposition of β-amyloid peptide within brain regions. It develops insoluble ...
Intranasal carvacrol nanoemulsion: Stroke imaging and neuroprotective study [0.03%]
鼻内丁香酚纳米乳剂：脑卒中的影像学和神经保护作用研究
Hitendra Mahajan,Ghanashyam Girnar
Hitendra Mahajan
Background and purpose: Cerebral ischemia causes neuronal damage due to restricted blood flow and presents significant challenges for brain-targeted drug delivery because of the blood-brain barrier. The purpose of this st...
Injectable hydrogels for bone regeneration: mechanical reinforcement strategies using nanoparticles and nanofibers [0.03%]
用于骨再生的可注射型水凝胶：利用纳米颗粒和纳米纤维增强机械性能的方法
Morteza Mirzagoli,Fariba Ganji,Lobat Tayebi
Morteza Mirzagoli
Background and purpose: The growing demand for bone regeneration following severe injuries highlights the importance of scaffolds in bone tissue engineering (BTE). Injectable hydrogels have emerged as promising candidates...
Insights into drug resistance in Leishmania: Mechanisms, therapeutics, and clinical case studies [0.03%]
莱什曼原虫药物抗性研究：机制、治疗及临床病例分析
Gajala Deethamvali Ghousepeer,Mansi Rani,Aman Kumar et al.
Gajala Deethamvali Ghousepeer et al.
Background and purpose: Leishmaniasis, a neglected tropical disease caused by the protozoan parasite Leishmania, remains a significant public health concern in endemic regions. The disease manifests in various forms, incl...
Hypotension and antiphlogistic potential of empagliflozin ocular film: swelling and release kinetics [0.03%]
恩格列净眼用膜的低血压与抗炎潜力：胀大和释放动力学研究
Tanisha Das,Subrata Mallick,Sourajit Parida et al.
Tanisha Das et al.
Background and purpose: Empagliflozin (EMP) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for the management of type 2 diabetes mellitus. The danger of glaucoma in type 2 diabetes mellitus patients is known t...