Abirami Soundiramourtty,Marie Mirouze
Abirami Soundiramourtty
Miniature inverted repeat transposable elements (MITEs) are short, non-autonomous transposable elements that have attracted considerable attention over the years due to their ubiquitous presence and functional roles in plant genomes. A grow...
Structural and transduction patterns of human-specific polymorphic SVA insertions [0.03%]
人类特有的多态性SVA插入的结构和转导模式
Ashley E Kirby,Mark Loftus,Emily C Golba;Human Genome Structural Variation Consortium;Miriam K Konkel
Ashley E Kirby
Background: SINE variable number tandem repeat Alu elements (SVAs) are a unique group of hominid-specific composite retrotransposons with highly variable internal structure. They represent the youngest TE family in humans...
A specialized bacterial group II intron is a highly efficient retrotransposon [0.03%]
一个专门化的细菌第II类内含子是高效的逆转座子
Lucie Gomes,Claire Toffano-Nioche,Daniel Gautheret et al.
Lucie Gomes et al.
Mobile group II introns are site-specific retrotransposons composed of a large self-splicing ribozyme and an intron-encoded reverse transcriptase that are widespread in bacterial and organellar genomes. Sequence and structural variations of...
High interferon response signatures in SLE patient leukocytes are associated with increased transposable element expression in gene introns and intergenic regions [0.03%]
系统性红斑狼疮患者白细胞中高I型干扰素反应特征与基因内含子和基因间区游离DNA增加相关
Leo J Arteaga-Vazquez,Hugo Sepulveda,Bruno Villalobos Reveles et al.
Leo J Arteaga-Vazquez et al.
Background: Systemic lupus erythematosus (SLE) is a spontaneous systemic auto-immune condition for which the inciting factors and genetic basis are generally unknown. Although heterogeneous in its manifestations and sever...
Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence [0.03%]
LINE-1/Alu元件与拮抗蛋白APOBEC3B在细胞衰老中的对抗调节作用
Daksha Munot,Yueshuang Lu,Isabell Haußmann et al.
Daksha Munot et al.
Long Interspersed Nuclear Elements-1 (LINE-1 or L1) make up approximately 21% of the human genome, with some L1 loci containing intact open reading frames (ORFs) that facilitate retrotransposition. Because retrotransposition can have delete...
Correction: A plan or pandemonium? The conundrum of retrotransposon activation in cancer [0.03%]
纠正：计划还是混乱？癌症中逆转座子激活的难题
Elina Zueva
Elina Zueva
Published Erratum
Mobile DNA. 2025 Oct 21;16(1):38. DOI:10.1186/s13100-025-00379-4 2025
Strict retroelement regulation is frequently lost following cancer transformation and generates a promising reservoir of cancer biomarkers [0.03%]
致癌转化后严格的逆转座子调节机制经常会丢失并产生一个充满希望的癌症生物标志物库
Eric Russ,Sergey Iordanskiy
Eric Russ
Background: Retroelements are repetitive sequences that comprise 42% of the human genome and are strictly regulated through various epigenetic mechanisms. Examining retroelement expression on a locus-specific level in rel...
Type I interferons increase expression of endogenous retrovirus K102 and envelope protein in myeloid cells from patients with autoimmune disease [0.03%]
I型干扰素增加自身免疫疾病患者髓系细胞内源性逆转录病毒K102的表达及其包膜蛋白的产生
Ethan Le,Fatemeh Moadab,Xiaoxing Wang et al.
Ethan Le et al.
Background: Autoantibodies against envelope (Env) protein encoded by human endogenous retrovirus group K (HERV-K) are prevalent in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), but it remains unclear w...
Gene and transposable element expression in response to stress in temperate and tropical populations of Drosophila [0.03%]
果蝇温带和热带种群响应胁迫的基因和转座子表达差异性分析
Miriam Merenciano,Daniel S Oliveira,Judit Salces-Ortiz et al.
Miriam Merenciano et al.
Background: The study of stress response in natural populations is crucial for understanding species local adaptation and evolution. In Drosophila, significant genetic diversity across populations from different geographi...
Comparative structural analysis of IS21 transposition complexes using Cryo-EM and AlphaFold3 [0.03%]
基于Cryo-EM和AlphaFold3的IS21转座复合物结构分析比较
Mercedes Spínola-Amilibia,Irene Rizzuto,Ernesto Arias-Palomo
Mercedes Spínola-Amilibia
Transposition is a fundamental driver of genome evolution, enabling the movement of discrete DNA segments (transposons) within genomes. This process can modulate gene expression and contributes to the spread of antibiotic resistance and vir...