Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation [0.03%]
内源性逆转录病毒与衰老和癌症：从基因组防御到致癌激活
Gabriel Arantes Dos Santos,Nathália Da Roz D&#x;Alessandre,Gabriela Der Agopian Guardia et al.
Gabriel Arantes Dos Santos et al.
Nearly half of the human genome consists of transposable elements, among which endogenous retroviruses, remnants of ancient retroviral infections, represent some of the most evolutionarily intriguing due to their paradoxical functional dual...
Maxfield M G Kelsey,Radha L Kalekar,John M Sedivy
Maxfield M G Kelsey
Background: The recognition that transposable elements (TEs) play important roles in many biological processes has elicited growing interest in analyzing sequencing data derived from this 'dark genome'. This goal is compl...
FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum [0.03%]
FoTeRs：存在于尖孢镰刀菌中的新型端粒相关逆转座子家族
Sahar Salimi,Mostafa Rahnama
Sahar Salimi
Transposable elements (TEs) are dynamic components of eukaryotic genomes, playing a crucial role in genome evolution and plasticity, particularly in unstable regions such as chromosome ends. In the globally significant fungal pathogen Fusar...
Abirami Soundiramourtty,Marie Mirouze
Abirami Soundiramourtty
Miniature inverted repeat transposable elements (MITEs) are short, non-autonomous transposable elements that have attracted considerable attention over the years due to their ubiquitous presence and functional roles in plant genomes. A grow...
Structural and transduction patterns of human-specific polymorphic SVA insertions [0.03%]
人类特有的多态性SVA插入的结构和转导模式
Ashley E Kirby,Mark Loftus,Emily C Golba;Human Genome Structural Variation Consortium;Miriam K Konkel
Ashley E Kirby
Background: SINE variable number tandem repeat Alu elements (SVAs) are a unique group of hominid-specific composite retrotransposons with highly variable internal structure. They represent the youngest TE family in humans...
A specialized bacterial group II intron is a highly efficient retrotransposon [0.03%]
一个专门化的细菌第II类内含子是高效的逆转座子
Lucie Gomes,Claire Toffano-Nioche,Daniel Gautheret et al.
Lucie Gomes et al.
Mobile group II introns are site-specific retrotransposons composed of a large self-splicing ribozyme and an intron-encoded reverse transcriptase that are widespread in bacterial and organellar genomes. Sequence and structural variations of...
High interferon response signatures in SLE patient leukocytes are associated with increased transposable element expression in gene introns and intergenic regions [0.03%]
系统性红斑狼疮患者白细胞中高I型干扰素反应特征与基因内含子和基因间区游离DNA增加相关
Leo J Arteaga-Vazquez,Hugo Sepulveda,Bruno Villalobos Reveles et al.
Leo J Arteaga-Vazquez et al.
Background: Systemic lupus erythematosus (SLE) is a spontaneous systemic auto-immune condition for which the inciting factors and genetic basis are generally unknown. Although heterogeneous in its manifestations and sever...
Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence [0.03%]
LINE-1/Alu元件与拮抗蛋白APOBEC3B在细胞衰老中的对抗调节作用
Daksha Munot,Yueshuang Lu,Isabell Haußmann et al.
Daksha Munot et al.
Long Interspersed Nuclear Elements-1 (LINE-1 or L1) make up approximately 21% of the human genome, with some L1 loci containing intact open reading frames (ORFs) that facilitate retrotransposition. Because retrotransposition can have delete...
Correction: A plan or pandemonium? The conundrum of retrotransposon activation in cancer [0.03%]
纠正：计划还是混乱？癌症中逆转座子激活的难题
Elina Zueva
Elina Zueva
Published Erratum
Mobile DNA. 2025 Oct 21;16(1):38. DOI:10.1186/s13100-025-00379-4 2025
Strict retroelement regulation is frequently lost following cancer transformation and generates a promising reservoir of cancer biomarkers [0.03%]
致癌转化后严格的逆转座子调节机制经常会丢失并产生一个充满希望的癌症生物标志物库
Eric Russ,Sergey Iordanskiy
Eric Russ
Background: Retroelements are repetitive sequences that comprise 42% of the human genome and are strictly regulated through various epigenetic mechanisms. Examining retroelement expression on a locus-specific level in rel...