African swine fever virus DEAD-box helicase D1133L promotes OGG1-driven incision of genomic 8-oxoG via HDAC5 deacetylation [0.03%]
非洲猪瘟病毒DEAD框解旋酶D1133L通过HDAC5去乙酰化促进OGG1介导的基因组8-oxoG切除反应
Jie Fan,Jifei Yang,Zhancheng Tian et al.
Jie Fan et al.
African swine fever virus (ASFV) infection induces oxidative stress and produces oxidative DNA damage bases, including 8-oxoguanine (8-oxoG). It is essential to promptly repair these damages to maintain genome stability. The enzyme 8-oxogua...
Identification and Characterization of a TGF-β-Independent SMAD4-NFATc1-STAT3 Regulatory Axis [0.03%]
TGF-β非依赖性SMAD4-NFATc1-STAT3信号轴的鉴定及其功能研究
Wukun Ouyang,Jiaying Hao,Qiankun Niu et al.
Wukun Ouyang et al.
SMAD4, a central mediator of the TGF-β signaling pathway, plays a critical role in regulating cellular processes such as proliferation, differentiation, and apoptosis. While SMAD4's canonical functions within TGF-β signaling are well-esta...
Targeting the ubiquitin-proteasome system and drug therapy in colorectal cancer [0.03%]
泛素-蛋白酶体系统在结直肠癌治疗中的作用及药物选择
Ruixin Su,Yingying Shao,Qian Wang et al.
Ruixin Su et al.
Colorectal cancer (CRC) is the third most prevalent malignancy worldwide and the second leading cause of cancer-associated deaths, posing a significant threat to human health. Given the limited therapeutic options and poor prognosis associa...
egr1 and egr4 regulate zebrafish renal regeneration by promoting foxm1 expression [0.03%]
早期生长反应基因1和4通过促进叉头框M1表达促进斑马鱼肾脏再生
Xian He,Yuhua Sun
Xian He
Early growth response (Egr) factors are involved in tissue development and repair. However, few studies have focused on the role of egr genes in renal regeneration after acute kidney injury (AKI) and the underlying mechanisms. In this study...
Dimerization of ACAP4 is essential for its function in cell migration [0.03%]
ACAP4二聚化对其在细胞迁移中的功能是必不可少的
Hongfei Ma,Jingjing He,Zhiyou Fang et al.
Hongfei Ma et al.
RNA-Binding Protein Rbm38 as a Multifaceted Post-Transcriptional Regulator in Zebrafish Pancreatic Development [0.03%]
斑马鱼胰腺发育中具有多种功能的转录后调节因子Rbm38蛋白
Xiangmin Zhang,Xianpeng Li,Rui Liu et al.
Xiangmin Zhang et al.
RNA-binding motif protein 38 (Rbm38), also known as RNPC1, is a major regulator of post-transcriptional gene expression. It represents a potential candidate gene linked to the susceptibility of type 2 diabetes, and decreased RBM38 expressio...
Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin [0.03%]
Aurora B通过同时稳定肌动蛋白II和波形蛋白维持有丝分裂细胞的球形形状
Chenxi Hou,Fazhi Yu,Cheng Cao et al.
Chenxi Hou et al.
Cells round up when they enter mitosis and maintain this rounded morphology until they pass the spindle assembly checkpoint during anaphase. However, the mechanisms that regulate and maintain this transient spherical state remain unclear. I...
Comments on 'Macrophages form dendrite-like pseudopods to enhance bacterial ingestion' [0.03%]
关于“巨噬细胞形成类似树突的伪足以增强细菌摄取”的评论
Changyuan Fan,Yaming Jiu
Changyuan Fan
The mechanoresponsive chromosomal passenger complex sustains furrow ingression under confinement [0.03%]
机械响应型染色体乘客复合物在约束条件下维持皮质环收缩入侵
Chenxin Wang,Jingjing Ding,Chao Wang et al.
Chenxin Wang et al.
Cells sense and respond to forces from neighbouring cells and the extracellular matrix during growth and division. When cells undergo mitosis in a confined environment like in tumour environment, high compressive stress causes unstable cell...
Jing Wang,Wen Meng
Jing Wang
Recent advances have revealed that cyclic guanosine monophosphate-adenosine monophosphate (AMP) synthase (cGAS), classically recognized as a cytosolic DNA sensor, plays crucial roles beyond innate immunity. Particularly in the adipose tissu...