β-alanine alleviates gout by inhibiting NLRP3 inflammasome activation [0.03%]
β-丙氨酸通过抑制NLRP3炎性小体活化缓解高尿酸血症和痛风
Xia-Ying Chen,Peng-Peng Zhu,Yuan Ying et al.
Xia-Ying Chen et al.
The NLRP3 inflammasome plays a pivotal role in mediating pro-inflammatory cytokine release and inducing pyroptosis. Its aberrant activation is implicated in various inflammatory diseases, including gout, a condition characterized by monosod...
NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle stem cell differentiation [0.03%]
miR-183和miR-96介导的烟酰胺单核苷酸(NMN)+亚细胞分布调节肌干细胞分化
Mei Ma,Ruisen Ma,Zhuoyang Li et al.
Mei Ma et al.
The intracellular abundance of NAD+, a vital metabolic cofactor, critically influences muscle stem cell (MuSC) function. However, the spatial regulation of NAD+ and its impact on MuSC function remain unclear. In this study, we demonstrated ...
Cyclin B3 dsRNA Orchestrate Meiotic Progression in Porcine Oocytes [0.03%]
猪卵母细胞cyclin B3 dsRNA协调减数分裂进程
Yanlong Zhu,Xi-Qing Jiang,Shuang Gao et al.
Yanlong Zhu et al.
Cyclin B3 (CCNB3) plays a critical regulatory role in mammalian meiosis. Studies in mice have demonstrated that CCNB3 interacts with CDK1 to modulate the activity of MPF, thereby driving meiotic progression. However, the functional mechanis...
A high-content phenotypic screen identifies luteolin as a repurposed drug to reduce pyruvate dehydrogenase phosphorylation and enhance energy production in CMTX6 cell models [0.03%]
一种高内涵表型筛选鉴定出黄芩素通过减少CMTX6细胞模型中丙酮酸脱氢酶磷酸化而增强能量产生以用于老药新用
Gonzalo Perez-Siles,Masahiro Nishide,Melina Ellis et al.
Gonzalo Perez-Siles et al.
In vitro oogenesis and parthenogenetic development of chicken female germ cells [0.03%]
鸡卵母细胞的体外培养及其孤雌发育
Yuxiao Ma,Changhao Yu,Jiahui Wei et al.
Yuxiao Ma et al.
In vitro reconstruction of gametogenesis is an important research direction in germ cell biology and assisted reproduction. While substantial progress has been made in the in vitro oogenesis of mammalian germ cells, analogous approaches in ...
Zbtb38 transcriptionally activates XIAP to regulate apoptosis in development and cancer [0.03%]
Zbtb38通过转录激活XIAP在发育和癌症中调节细胞凋亡
Toshiaki Shigeoka,Hiroyuki Nagaoka,Nunuk Aries Nurulita et al.
Toshiaki Shigeoka et al.
The X-linked inhibitor of apoptosis protein (XIAP) is a key suppressor of apoptosis, crucial for cellular differentiation, embryogenesis, and cancer progression. However, its upstream regulatory mechanisms remain poorly understood. Here, we...
Jie Xu,Haikun Hu,Qingyi Lu et al.
Jie Xu et al.
The spleen tyrosine kinase (SYK) plays pivotal roles in the adaptive immune response by recognizing phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) and activating downstream effectors. However, the emergence of SYK pred...
Transcriptional co-activators YAP/TAZ in cancer-associated fibroblasts are dispensable for Notch-driven intrahepatic cholangiocarcinoma [0.03%]
转录辅激活因子YAP/TAZ对于 notch驱动的肝内胆管癌相关成纤维细胞是不需要的
Tingting Deng,Yuemei Qiao,Xinyu Xie et al.
Tingting Deng et al.
Preserving the UFMylation-cilium axis mitigates blue light-induced retinal degeneration [0.03%]
维持UFMylation-纤毛轴可减轻蓝光诱导的视网膜退行性变
Guizhi Guo,Runa Wang,Sai Zhang et al.
Guizhi Guo et al.
Blue light damage (BLD) is a complex process implicated in a variety of ocular diseases, including age-related macular degeneration and dry eye diseases. However, the molecular mechanisms underlying the BLD process remain largely unknown. I...
Methylation of MATCAP by PRMT5 regulates microtubule detyrosination to ensure mitotic fidelity [0.03%]
PRMT5甲基化MATCAP调节微管脱 tyr 作用以确保有丝分裂的保真度
Tongtong Yang,Wenping Hu,Yaqian Zhang et al.
Tongtong Yang et al.
During mitosis, motor protein-driven chromosome motility is essential for faithful chromosome segregation. The tubulin code, comprising tubulin isotypes and post-translational modifications, guides motor proteins along microtubules. Recent ...