Loss of the cardiac-enriched mitochondrial transporter SLC25A34 promotes heart failure by attenuating fatty acid oxidation [0.03%]
心脏丰富型线粒体转运蛋白SLC25A34的丢失通过抑制脂肪酸氧化促进心力衰竭
Jieyuan Xue,Yin Long,Jiayu Zhou et al.
Jieyuan Xue et al.
Heart failure is characterized by profound structural and metabolic remodeling. Members of the solute carrier family 25 (SLC25), as inner mitochondrial membrane proteins, play critical roles in mitochondrial dysfunction during heart failure...
APLN: A Promising Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma [0.03%]
APLN：肝细胞癌诊断和预后生物标志物的有力候选者
Jiwu Guo,Wenzhang Wu,Yujing Qi et al.
Jiwu Guo et al.
Leqian Lin,Xintong Li,Yimeng Li et al.
Leqian Lin et al.
Decidualization of human endometrial stromal cells (hESCs) during the secretory phase is critical for implantation and pregnancy. In this study, we assessed 25 established in vitro decidualization markers using in vivo single-cell transcrip...
Chen Wang,Xiao Tang,Qiaobin Yao et al.
Chen Wang et al.
Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a master regulator of cell growth, survival, and differentiation. Normally, SHP2 is kept in a self-inhibited state, in which its N-terminal SH2 ...
Cytosolic transmembrane helices enter the ER membrane through EMC6-driven electrostatic interactions [0.03%]
胞质跨膜螺旋通过EMC6驱动的静电相互作用进入内质网膜
Hongyan Zheng,Wenxue Gu,Tong Zhou et al.
Hongyan Zheng et al.
The endoplasmic reticulum membrane protein complex (EMC) facilitates transmembrane domain (TMD) insertion and translocation of small terminal domains. Here, we identify EMC as a critical determinant of epithelial sodium channel (ENaC) biosy...
Structural basis of complex assembly and nucleosome recognition by the chromatin remodeling ncBAF complex [0.03%]
染色质重塑ncBAF复合体的复杂装配及核小体识别的结构基础
Wancheng Xu,Shengsheng Ma,Yi Li et al.
Wancheng Xu et al.
BRG1/BRM-associated factor (BAF)-family chromatin remodelers regulate transcription and genome organization by repositioning nucleosomes. The human non-canonical BAF (ncBAF) complex is uniquely defined by the presence of BRD9 and GLTSCR1/GL...
Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice [0.03%]
微管结合蛋白CCDC112对小鼠精子形成和雄性生育力是必需的
Qingchao Li,Xirui Zi,Yue Lu et al.
Qingchao Li et al.
Defective sperm motility is frequently associated with male infertility. The immotile short-tail sperm (ISTS) defect is a rare condition in which most sperm cells have abnormally short tails, impairing their motility and leading to infertil...
A non-proteolytic role of SARS-CoV-2 PLpro in modulating host glycyl-tRNA synthetase activity [0.03%]
SARS-CoV-2PLpro的非蛋白酶作用调节宿主甘氨酰-tRNA合成酶活性
Jia-Li Lu,Yue Yin,Xiao-Long Zhou
Jia-Li Lu
ITIH5 Drives Adipocyte Differentiation and Obesity-Associated Metabolic Dysregulation via PI3K/AKT Signaling Activation [0.03%]
ITIH5通过激活PI3K / AKT信号传导驱动脂肪细胞分化和与肥胖相关的代谢紊乱
Dan Li,Maoxiang Xu,Jie Li et al.
Dan Li et al.
Obesity markedly increases the risk of type 2 diabetes, highlighting the urgent need for novel therapeutic targets. The inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5), which is predominantly produced by the adipose tissue, has emerged ...