Luonan Chen,Jiarui Wu
Luonan Chen
Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA [0.03%]
Srs2借助于非典型PIP盒和SBM精确识别泛素连接酶RFC2的SUMO化位点
Seong Ok Kim,Hyerim Yoon,Seong Oak Park et al.
Seong Ok Kim et al.
Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing [0.03%]
Bicc1将多囊肾cAMP信号转导的调节与微orna诱导的基因沉默联系起来
Nathalie Piazzon,Charlotte Maisonneuve,Isabelle Guilleret et al.
Nathalie Piazzon et al.
Genetic defects in autosomal-dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We sho...
Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes [0.03%]
PARK 基因的年龄和饮食依赖性需求与小鼠葡萄糖稳态及人类2型糖尿病的关系
Deepak Jain,Ruchi Jain,Daniel Eberhard et al.
Deepak Jain et al.
Elderly patients often suffer from multiple age-related diseases. Here we show that the expression of DJ-1, an antioxidant protein with reduced expression in the central nervous system of patients with Parkinson's disease, is reduced in pan...
USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6 [0.03%]
USP2a通过去泛素化TRAF6负向调控IL-1β和病毒诱导的NF-κB活化
Xiao He,Yi Li,Chao Li et al.
Xiao He et al.
The transcription factor NF-κB plays critical roles in many biological processes, especially immunity. The signaling to NF-κB activation is subtly regulated to avoid harmful immune effects. In this report, we identified ubiquitin-specific...
Regenerative medicine using adult neural stem cells: the potential for diabetes therapy and other pharmaceutical applications [0.03%]
利用成人神经干细胞的再生医学：糖尿病治疗及其他药物应用的潜力
Tomoko Kuwabara,Makoto Asashima
Tomoko Kuwabara
Neural stem cells (NSCs), which are responsible for continuous neurogenesis during the adult stage, are present in human adults. The typical neurogenic regions are the hippocampus and the subventricular zone; recent studies have revealed th...
Quantitative mathematical modeling of PSA dynamics of prostate cancer patients treated with intermittent androgen suppression [0.03%]
间断雄激素剥夺治疗前列腺癌患者的PSA动力学的定量数学建模
Yoshito Hirata,Koichiro Akakura,Celestia S Higano et al.
Yoshito Hirata et al.
If a mathematical model is to be used in the diagnosis, treatment, or prognosis of a disease, it must describe the inherent quantitative dynamics of the state. An ideal candidate disease is prostate cancer owing to the fact that it is chara...
The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor [0.03%]
MEK抑制剂的抗肿瘤疗效取决于ERK和PI3K信号通路之间的交叉调节作用
Jae-Kyung Won,Hee Won Yang,Sung-Young Shin et al.
Jae-Kyung Won et al.
MEK inhibitor has been highlighted as a promising anti-tumor drug but its effect has been reported as varying over a wide range depending on patho-physiological conditions. In this study, we employed a systems approach by combining biochemi...
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer [0.03%]
AIMP2拼接变异体作为化疗耐药性卵巢癌的有效靶点
Jin Woo Choi,Jeong-Won Lee,Jun Ki Kim et al.
Jin Woo Choi et al.
Chemoresistance is a main cause for the failure of cancer management and intensive investigation is on-going to control chemoresistant (CR) cancers. Although NF-κB has been suggested as one of the potential targets to alleviate chemoresist...
Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster [0.03%]
缺氧和降低的能量效率与促进细胞增殖的信号之间的错配驱动癌症生长得越来越快
Juan Cui,Xizeng Mao,Victor Olman et al.
Juan Cui et al.