Transcriptional activation of endothelial cells by TGFβ coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury [0.03%]
转化生长因子TGFβ激活内皮细胞的转录与脊髓缺血/再灌注损伤后急性微血管重塑同步发生
Richard L Benton,Melissa A Maddie,Toros A Dincman et al.
Richard L Benton et al.
Microvascular dysfunction, loss of vascular support, ischaemia and sub-acute vascular instability in surviving blood vessels contribute to secondary injury following SCI (spinal cord injury). Neither the precise temporal profile of the cell...
Comparative Study
ASN neuro. 2009 Aug 26;1(3):e00015. DOI:10.1042/AN20090008 2009
Different proteolipid protein mutants exhibit unique metabolic defects [0.03%]
不同类型的蛋白脂质蛋白突变体存在不同的代谢缺陷
Maik Hüttemann,Zhan Zhang,Chadwick Mullins et al.
Maik Hüttemann et al.
PMD (Pelizaeus-Merzbacher disease), a CNS (central nervous system) disease characterized by shortened lifespan and severe neural dysfunction, is caused by mutations of the PLP1 (X-linked myelin proteolipid protein) gene. The majority of hum...
Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination [0.03%]
小鼠穹窿部杯rizone脱髓鞘与社交行为改变及双手双足协调性受损相关
Norah Hibbits,Ravinder Pannu,T John Wu et al.
Norah Hibbits et al.
For studies of remyelination in demyelinating diseases, the cuprizone model of CC (corpus callosum) demyelination has experimental advantages that include overall size, proximity to neural stem cells of the subventricular zone, and correlat...
In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours [0.03%]
体外培养环境导致非致瘤性星形胶质细胞和脑肿瘤线粒体脂质组及电子传递链异常
Michael A Kiebish,Xianlin Han,Hua Cheng et al.
Michael A Kiebish et al.
The mitochondrial lipidome influences ETC (electron transport chain) and cellular bioenergetic efficiency. Brain tumours are largely dependent on glycolysis for energy due to defects in mitochondria and oxidative phosphorylation. In the pre...
Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour [0.03%]
海马中昼夜钟基因Period2的表达：其对突触可塑性和习得行为的影响的可能意义
Louisa M-C Wang,Joanna M Dragich,Takashi Kudo et al.
Louisa M-C Wang et al.
Genes responsible for generating circadian oscillations are expressed in a variety of brain regions not typically associated with circadian timing. The functions of this clock gene expression are largely unknown, and in the present study we...
Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers [0.03%]
APP23/Abca1+/-小鼠的学习记忆障碍与寡聚体Aβ水平相关性研究
Iliya Lefterov,Nicholas F Fitz,Andrea Cronican et al.
Iliya Lefterov et al.
ABCA1, a member of the ATP-binding cassette family of transporters, lipidates ApoE (apolipoprotein A) and is essential for the generation of HDL (high-density lipoprotein)-like particles in the CNS (central nervous system). Lack of Abca1 in...
MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses [0.03%]
脑脓肿中CNS resident细胞表达的MyD88对于诱导保护性免疫至关重要
Sarita Garg,Jessica R Nichols,Nilufer Esen et al.
Sarita Garg et al.
MyD88 KO (knockout) mice are exquisitely sensitive to CNS (central nervous system) infection with Staphylococcus aureus, a common aetiological agent of brain abscess, exhibiting global defects in innate immunity and exacerbated tissue damag...
When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation [0.03%]
当尾巴不能摇狗时：中枢神经系统内在的神经炎症启动的影响
Deirdre S Davis,Monica J Carson
Deirdre S Davis
The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been ...
Brain injury expands the numbers of neural stem cells and progenitors in the SVZ by enhancing their responsiveness to EGF [0.03%]
脑损伤通过增强其对EGF的反应性增加SVZ中神经干细胞和祖细胞的数量
Dhivyaa Alagappan,Deborah A Lazzarino,Ryan J Felling et al.
Dhivyaa Alagappan et al.
There is an increase in the numbers of neural precursors in the SVZ (subventricular zone) after moderate ischaemic injuries, but the extent of stem cell expansion and the resultant cell regeneration is modest. Therefore our studies have foc...
Comparative Study
ASN neuro. 2009 May 20;1(2):e00009. DOI:10.1042/AN20090002 2009
Inflammatory cytokines IL-1β and TNF-α regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms [0.03%]
炎症细胞因子IL-1β和TNF-α通过不同的细胞类型特异性信号转导机制调节中枢神经系统神经元和星形胶质细胞中p75NTR的表达
Soyoung Choi,Wilma J Friedman
Soyoung Choi
The p75NTR (where NTR is neurotrophin receptor) can mediate many distinct cellular functions, including cell survival and apoptosis, axonal growth and cell proliferation, depending on the cellular context. This multifunctional receptor is w...