Glial glucokinase expression in adult and post-natal development of the hypothalamic region [0.03%]
成年及产后下丘脑区域胶质己糖激酶的表达
Carola Millán,Fernando Martínez,Christian Cortés-Campos et al.
Carola Millán et al.
It has recently been proposed that hypothalamic glial cells sense glucose levels and release lactate as a signal to activate adjacent neurons. GK (glucokinase), the hexokinase involved in glucose sensing in pancreatic beta-cells, is also ex...
Comparative Study
ASN neuro. 2010 May 25;2(3):e00035. DOI:10.1042/AN20090059 2010
The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass [0.03%]
神经源性碱性螺旋环螺旋转录因子NeuroD6通过触发抗氧化反应和维持线粒体生物量来承受氧化应激
Martine Uittenbogaard,Kristin Kathleen Baxter,Anne Chiaramello
Martine Uittenbogaard
Preserving mitochondrial mass, bioenergetic functions and ROS (reactive oxygen species) homoeostasis is key to neuronal differentiation and survival, as mitochondria produce most of the energy in the form of ATP to execute and maintain thes...
Comparative Study
ASN neuro. 2010 May 24;2(2):e00034. DOI:10.1042/AN20100005 2010
Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms [0.03%]
亨廷顿舞蹈病的小鼠模型：聚焦于电生理机制
Carlos Cepeda,Damian M Cummings,Véronique M André et al.
Carlos Cepeda et al.
The discovery of the HD (Huntington's disease) gene in 1993 led to the creation of genetic mouse models of the disease and opened the doors for mechanistic studies. In particular, the early changes and progression of the disease could be fo...
Hyperglycaemia and diabetes impair gap junctional communication among astrocytes [0.03%]
高血糖和糖尿病损害星形胶质细胞间的连接蛋白通讯功能
Gautam K Gandhi,Kelly K Ball,Nancy F Cruz et al.
Gautam K Gandhi et al.
Sensory and cognitive impairments have been documented in diabetic humans and animals, but the pathophysiology of diabetes in the central nervous system is poorly understood. Because a high glucose level disrupts gap junctional communicatio...
Comparative Study
ASN neuro. 2010 Mar 15;2(2):e00030. DOI:10.1042/AN20090048 2010
A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death [0.03%]
Bax基因启动子单核苷酸多态性影响转录并影响视网膜神经节细胞死亡
Sheila J Semaan,Yan Li,Robert W Nickells
Sheila J Semaan
Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/-) ...
Comparative Study
ASN neuro. 2010 Mar 31;2(2):e00032. DOI:10.1042/AN20100003 2010
Molecules and mechanisms involved in the generation and migration of cortical interneurons [0.03%]
与皮层中间神经元发生和迁移有关的分子和机制
Luis R Hernández-Miranda,John G Parnavelas,Francesca Chiara
Luis R Hernández-Miranda
The GABA (γ-aminobutyric acid)-containing interneurons of the neocortex are largely derived from the ganglionic eminences in the subpallium. Numerous studies have previously defined the migratory paths travelled by these neurons from their...
Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus [0.03%]
嗅觉辨别训练可上调并重构成年鼠海马微小核糖核酸的表达模式
Neil R Smalheiser,Giovanni Lugli,Angela L Lenon et al.
Neil R Smalheiser et al.
Adult male mice (strain C57Bl/6J) were trained to execute nose-poke responses for water reinforcement; then they were randomly assigned to either of two groups: olfactory discrimination training (exposed to two odours with reward contingent...
Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells [0.03%]
GM1神经节苷脂和β淀粉样蛋白肽对小鼠胚胎神经干细胞的细胞毒作用
Makoto Yanagisawa,Toshio Ariga,Robert K Yu
Makoto Yanagisawa
AD (Alzheimer's disease) is a neurodegenerative disease and the most common form of dementia. One of the pathological hallmarks of AD is the aggregation of extracellular Aβs (amyloid β-peptides) in senile plaques in the brain. The process...
The multiple roles of myelin protein genes during the development of the oligodendrocyte [0.03%]
髓磷脂蛋白基因在少突胶质细胞发育过程中的多种作用
Daniel Fulton,Pablo M Paez,Anthony T Campagnoni
Daniel Fulton
It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2',3'-cyclic ...
Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes [0.03%]
淀粉样β-肽直接诱导原代大鼠皮层星形胶质细胞内钙离子瞬变、迟发性细胞间钙波及胶质增生
Siu-Kei Chow,Diana Yu,Christopher L Macdonald et al.
Siu-Kei Chow et al.
The contribution of astrocytes to the pathophysiology of AD (Alzheimer's disease) and the molecular and signalling mechanisms that potentially underlie them are still very poorly understood. However, there is mounting evidence that calcium ...