A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
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Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/-) mice exhibited compl... ...
