Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate [0.03%]
寡聚型β淀粉样蛋白通过NADPH氧化酶介导的ROS产生使皮质神经元的NMDA受体功能受损：绿茶儿茶素对上述损伤具有保护作用
Yan He,Jiankun Cui,James C-M Lee et al.
Yan He et al.
Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well understood, aggregation of Aβ is known to cause toxicity to neurons. Our recen...
Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells [0.03%]
人胚胎神经干细胞中GD2和GD3神经节苷脂的表达
Makoto Yanagisawa,Saori Yoshimura,Robert K Yu
Makoto Yanagisawa
NSCs (neural stem cells) are undifferentiated neural cells endowed with a high potential for proliferation and a capacity for self-renewal with retention of multipotency to differentiate into neurons and glial cells. It has been recently re...
Sex-specific activation of cell death signalling pathways in cerebellar granule neurons exposed to oxygen glucose deprivation followed by reoxygenation [0.03%]
氧葡萄糖剥夺再灌注后小脑颗粒神经元中性别特异性细胞死亡信号通路的激活
Jaswinder Sharma,Geetha Nelluru,Mary Ann Wilson et al.
Jaswinder Sharma et al.
Neuronal death pathways following hypoxia-ischaemia are sexually dimorphic, but the underlying mechanisms are unclear. We examined cell death mechanisms during OGD (oxygen-glucose deprivation) followed by Reox (reoxygenation) in segregated ...
The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1 [0.03%]
二甲基呋塞米在星形胶质细胞中的抗炎作用涉及谷胱甘肽和血红素氧合酶-1
Shao Xia Lin,Lucia Lisi,Cinzia Dello Russo et al.
Shao Xia Lin et al.
DMF (dimethyl fumarate) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, and a formulation (BG-12) is being evaluated for monotherapy in multiple sclerosis patients. DMF modifies glutathione (GSH) levels that c...
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions [0.03%]
Calpain和caspase-3蛋白酶在神经毒性和神经退行性病变条件下对Tau的双重脆弱性
Ming Cheng Liu,Firas Kobeissy,Wenrong Zheng et al.
Ming Cheng Liu et al.
Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy). Such tau aggregate is f...
Oligodendrocyte progenitor cells proliferate and survive in an immature state following treatment with an axolemma-enriched fraction [0.03%]
轴膜富集组分处理后寡突胶质前体细胞以未成熟状态增殖并存活
Sara G Becker-Catania,Julie K Nelson,Shantel Olivares et al.
Sara G Becker-Catania et al.
The ability of an AEF (axolemma-enriched fraction) to influence the proliferation, survival and differentiation of OPC (oligodendrocyte progenitor cells) was evaluated. Following addition of AEF to cultured OPC, the AEF associated with the ...
Jean-Marie Mangin,Vittorio Gallo
Jean-Marie Mangin
It has been 10 years since the seminal work of Dwight Bergles and collaborators demonstrated that NG2 (nerve/glial antigen 2)-expressing oligodendrocyte progenitor cells (NG2 cells) receive functional glutamatergic synapses from neurons (Be...
Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination [0.03%]
缺氧/缺血损伤后apotransferrin诱导的髓鞘恢复作用
Mariano Guardia Clausi,Laura A Pasquini,Eduardo F Soto et al.
Mariano Guardia Clausi et al.
We have previously demonstrated that aTf (apotransferrin) accelerates maturation of OLs (oligodendrocytes) in vitro as well as in vivo. The purpose of this study is to determine whether aTf plays a functional role in a model of H/I (hypoxia...
Comparative Study
ASN neuro. 2010 Nov 19;2(5):e00048. DOI:10.1042/AN20100020 2010
The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective [0.03%]
小胶质细胞在突触清除和突触退行中的作用：一种新的观点
V Hugh Perry,Vincent O&#x;Connor
V Hugh Perry
Chronic neurodegenerative diseases of the CNS (central nervous system) are characterized by the loss of neurons. There is, however, growing evidence to show that an early stage of this process involves degeneration of presynaptic terminals ...
Aiwu Cheng,Yan Hou,Mark P Mattson
Aiwu Cheng
The production of neurons from neural progenitor cells, the growth of axons and dendrites and the formation and reorganization of synapses are examples of neuroplasticity. These processes are regulated by cell-autonomous and intercellular (...