Age-associated increase in AT1R expression in human testis and its intervention effects on Leydig cell senescence in aged rodents [0.03%]
人睾丸中AT1R表达随年龄增长而增加及其对老年动物Leydig细胞衰老的干预效应
Minye Zhao,Jinhua Wei,Yao Geng et al.
Minye Zhao et al.
The active peptide hormone Ang II (angiotensin II) mediates the vast majority of the RAS (renin-angiotensin system) action, mainly through activation of AT1R (Angiotensin II type-1 receptor). AT1R expression peaks in newborn males and decre...
Modulating brain activity to improve goal-directed physical activity in older adults: a pilot randomized controlled trial [0.03%]
调节大脑活动以改善老年人的目标导向身体活动：一项初步的随机对照试验
On-Yee Lo,Levi Ask,Melike Kahya et al.
On-Yee Lo et al.
Background: Insufficient physical activity in older adults remains a global health issue. Several interrelated factors contributing to inactivity are linked to the prefrontal cortex. We conducted a pilot study to assess t...
Ethnic and Sex Differences in the Association Between Organochlorine Exposure and Cognitive Function in Late Life [0.03%]
有机氯暴露与晚年认知功能关系中的种族和性别差异
Marianne Chanti-Ketterl,María P Aranda,Brenda L Plassman
Marianne Chanti-Ketterl
Background: Organochlorine pesticides persist in the environment and body for extended periods. However, little is known about their long-term impact on cognition in older adults and if their influence differs by race/eth...
Cognitive Performance and Long-term Exposure to Outdoor Air Pollution: Findings from the Harmonised Cognitive Assessment Protocol Sub-Study of the English Longitudinal Study of Ageing (ELSA-HCAP) [0.03%]
长期暴露于室外空气污染对认知能力的影响：来自英国老龄化纵向研究(ELSA-HCAP)协调认知评估协议子研究的发现
Giorgio DI Gessa,Mikaela Bloomberg,Rina So et al.
Giorgio DI Gessa et al.
Background: Although air pollution is associated with worse cognitive performance, whether these relationships differ by cognitive domain and which sources of air pollution are particularly detrimental to cognition remain...
Epigenetic Clocks Relate to Four Age-Related Health Outcomes Similarly across Three Countries [0.03%]
表观遗传钟与四个与年龄相关的健康结果在三个国家中的关系相似
Eileen M Crimmins,Belinda Hernandez,Claire Potter et al.
Eileen M Crimmins et al.
Background: Measures of epigenetic age have been linked to life circumstances and health outcomes in older populations. The similarity of these relationships across multiple populations in well-harmonized data has not bee...
Reciprocal associations between trajectories of physical activity and physical function among older women: findings from the Australian Longitudinal Study on Women's Health [0.03%]
身体活动轨迹和老年女性物理功能之间的相互关系：来自澳大利亚妇女健康纵向研究的结论
Yuta Nemoto,Wendy J Brown,Geeske Peeters et al.
Yuta Nemoto et al.
Background: While physical activity (PA) is known to improve physical function (PF), and functional decline impacts the capacity to engage in PA, the reciprocal relationship between PA and PF remains unclear. ...
Human Peripheral Blood Leukocyte Transcriptome-based Aging Clock Reveals Acceleration of Aging by Bacterial or Viral Infections [0.03%]
基于人类外周血白细胞转录组的衰老时钟揭示细菌或病毒感染加速衰老的过程
Xin Gao,Si-Jia Li,Jian-Ping Cai
Xin Gao
The aging of the population is a global concern. In the post-COVID-19 pandemic era, there are no effective methods to identify aging acceleration due to infection. In this study, we conducted whole-transcriptome sequencing on peripheral blo...
Characterization of Dynamic Adaptation to Stressors using Multi-System Stimulus-Response Data: The Study of Physical Resilience in Aging Pilot [0.03%]
使用多系统刺激响应数据表征对压力源的动态适应性：关于老龄化飞行试验的物理弹性研究
Karen Bandeen-Roche,Jiafeng Zhu,Qian-Li Xue et al.
Karen Bandeen-Roche et al.
Resilience to stressors has emerged as a major gerontological concept aiming to promote more positive outcomes for older adults. Achieving this aim relies on determining mechanisms underlying capacity to respond resiliently. This paper seek...
Intrinsic Capacity Trajectories: Implications for Subsequent Falls and Hospitalizations among Older Adults [0.03%]
内在能力轨迹：对老年人随后跌倒和住院的影响
Xiaodong Chen,Lingxiao He,Kewei Shi et al.
Xiaodong Chen et al.
Background: Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, the association between IC trajectories and falls and hospitalizations remains uncertain. This study aimed t...