Palliative and end-of-life care as fragile collective accomplishment: social and medical perspectives [0.03%]
Markus H Schafer,Raya Elfadel Kheirbek
Markus H Schafer
Current Perspectives and Emerging Directions in Research and Practice: Highlights from the 15th Annual International Workshop on Aging and HIV [0.03%]
Jun Y Byun,Raymond Jones,Evelyn Iriarte et al.
Jun Y Byun et al.
The 15th Annual International Workshop on Aging and HIV (October 24-25, 2024) centered on integrating aging-related science into HIV research and care and aimed to advance interdisciplinary exchange and identify actionable priorities for re...
Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice [0.03%]
Rashmi Singh,Vanessa Elia Calderon,Holstein Deborah et al.
Rashmi Singh et al.
Interventions Testing Program identified rapamycin as a robust lifespan-extending agent at multiple testing sites and in both sexes, with particularly strong effects in females, making it a leading candidate in aging research. We used genet...
Symptom-based indicators of autonomic dysfunction and their bidirectional associations with Parkinson's disease incidence and adverse outcomes [0.03%]
Tianmi Yang,Qianqian Wei,Dejiang Pang et al.
Tianmi Yang et al.
Background: Symptom-based indicators suggestive of autonomic dysfunction are common but under-recognized in Parkinson's disease (PD), with potential implications as a biomarker of aging for early detection and prognosis. ...
Oral microbiome and Frailty: Insights from NHANES 2009-2012 and Mendelian Randomization Analysis [0.03%]
Ting Xu,Xichenhui Qiu,Qiqi Hang et al.
Ting Xu et al.
Background: Frailty is associated with increased risks of disability, hospitalization, and mortality. Emerging evidence suggests that the oral microbiome may influence frailty development, but population-based evidence is...
Deep survival modelling to predict future cognitive impairment in unimpaired adults [0.03%]
深度生存模型预测无认知障碍成年人未来出现的认知障碍状况
Phoebe Imms,Haoqing Wang,Samayan Bhattacharya et al.
Phoebe Imms et al.
Background: Predicting Alzheimer's disease (AD)-related cognitive impairment (CI) among cognitively normal (CN) adults enables meaningful disease modification through early intervention and enrichment of clinical trials. ...
Protective Effect of the FOXO3 Gene in Cardiometabolic Disease in the CHAMP Cohort [0.03%]
FOXO3基因对CHAMP队列心血管代谢性疾病的保护作用
Lovina Abdi,Glen Lockwood,Jarrod J Kennedy et al.
Lovina Abdi et al.
Recent findings from the Honolulu Heart Program cohort in Hawaii suggest a longevity-associated variant of FOXO3 may provide resilience against cardiometabolic diseases (CMD), such as hypertension, diabetes, and angina. The present study ut...
Assessing Health in Aging Male and Female Mice: Does Cardiac Function Dictate Frailty or Physical Resilience? [0.03%]
评估衰老小鼠的健康状况：心脏功能决定虚弱还是身体韧性？
Grecia Garcia Marquez,George E Taffet,Katarzyna A Cieslik
Grecia Garcia Marquez
As the global population over age 65 is projected to triple by 2050, understanding the physiological mechanisms of aging and the role of sex as a biological variable (SABV) is critical. Research conducted on old mice demonstrates that age-r...
Using Observational Data to Investigate Cognitive Outcomes of Obstructive Sleep Apnea Treatment: A Scoping Review [0.03%]
基于观察性数据探究阻塞性睡眠呼吸暂停治疗的认知结局：系统综述式回顾研究
Christopher N Kaufmann,Kevin H Yang,Chien-Yu Irene Tseng et al.
Christopher N Kaufmann et al.
Background: Prior research indicates a connection between obstructive sleep apnea (OSA) and cognitive deficits, prompting interest in whether OSA treatment can prevent or slow cognitive decline. Past clinical trials on OS...
Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging's Intervention Testing Program Data [0.03%]
通过解决聚类和嵌套效应提高动物衰老研究的统计严谨性：以国家老龄化研究所干预测试项目数据为例
Erik S Parker,Lilian Golzarri-Arroyo,Stephanie Dickinson et al.
Erik S Parker et al.
Clustering effects, such as those introduced by housing animals in shared cages, are often overlooked in preclinical lifespan studies, despite their potential to underestimate variance estimates and inflate Type I error rates, leading to mi...