Physical Activity and Sitting over 9 years of the Women's Health Initiative Strong & Healthy (WHISH) Randomized Physical Activity Intervention Trial in Older Women [0.03%]
女性健康倡议中体力活动和久坐行为的纵向变化——一项关于老年人身体健康的随机试验（2005-2014）
Marcia L Stefanick,Sally F Mackey,Joseph C Larson et al.
Marcia L Stefanick et al.
Background: The Women's Health Initiative (WHI) Strong & Healthy (WHISH) randomized trial implemented a 9-year remotely-delivered "light touch" multicomponent physical activity intervention (PA-I) aimed at increasing phys...
Mechanistic and functional study of lncRNA SNHG3/miR-128-3p/UBR5 axis in neuroinflammation in Alzheimer's disease [0.03%]
长链非编码RNA SNHG3/miR-128-3p/UBR5轴在阿尔茨海默病神经炎症中的作用及机制研究
Xin-An Zhu,Huijie Lu,Yumei Liu et al.
Xin-An Zhu et al.
Neuroinflammation assumes a pivotal role in Alzheimer's disease (AD) pathogenesis. Long noncoding RNAs (lncRNAs) regulate neuroinflammation through a competitive endogenous RNA (ceRNA) mechanism. This study aimed to explore the mechanism of...
Immune status modifies the association between plasma zonulin-1 and skeletal-related events in treated HIV: a case-cohort study [0.03%]
免疫状态修改了治疗HIV患者的血浆zonulin-1与骨骼相关事件之间的关联：一项病例队列研究
Carlos Pita-Martínez,Marta Rava,Ana Muñoz-Gomez et al.
Carlos Pita-Martínez et al.
Chronic inflammation driven by microbial translocation is implicated in the increased risk of skeletal-related events (SREs) among people with HIV (PWH) on antiretroviral therapy (ART). We aimed to assess the association between plasma biom...
Five-year disability trajectories and associated factors among adults aging with HIV in the Ontario HIV Treatment Network Cohort Study [0.03%]
安大略艾滋病治疗网络队列研究中HIV感染者的五年残疾轨迹及影响因素
Tai-Te Su,Lisa Avery,Ahmed M Bayoumi et al.
Tai-Te Su et al.
Disability among adults aging with HIV may be episodic and change over time. Guided by the Episodic Disability Framework, we examined disability trajectories, year-to-year fluctuations, and contextual factors associated with disability amon...
The relationship between parity and late-life frailty: companion dogs as a preclinical model for evaluating factors that aggravate or mitigate the frailty cost of reproduction [0.03%]
性别与老年衰弱的关系：伴侣犬作为评估加剧或缓解繁殖代价的前临床模型
David J Waters,Aimee H Maras,Rong Fu et al.
David J Waters et al.
Frailty refers to a state of heightened vulnerability to adverse health outcomes. Animal models of frailty provide an opportunity to probe lifetime events and exposures that drive frailty progression and to evaluate intervention strategies ...
Extracellular Vesicles and Epigenetic Aging Clocks in Tissue Aging: An Exosome-Focused Conceptual Framework with a Focus on Skin [0.03%]
细胞外囊泡和表观遗传衰老时钟在组织衰老中的作用：以皮肤为重点的外泌体概念框架
Zeynep Yaren Dinçer,Kaan Zikşahna,Murat Ihlamur
Zeynep Yaren Dinçer
Tissue aging is a multifactorial process characterized by cellular senescence, disrupted intercellular communication, and epigenetic alterations, with skin providing a clinically accessible and biologically informative model system. Exosome...
Metabolomic signatures and causal effects of circulating metabolites on age-related cataract [0.03%]
循环代谢产物与年龄相关性白内障的因果效应及代谢标志物指纹识别研究
Xing-Xuan Dong,Shi-Yi Gong,Jia-Yan Kai et al.
Xing-Xuan Dong et al.
Background: Age-related cataract (ARC) is a leading cause of visual impairment and blindness among older adults, yet effective pharmacological options remain limited. This study aimed to identify candidate circulating met...
Urinary Metabolic Age from High-Resolution NMR Reveals Longitudinal Aging Patterns [0.03%]
基于高分辨率核磁共振的尿液代谢年龄揭示了纵向衰老模式
Karen Friederike Gauß,Nele Friedrich,Ann-Kristin Henning et al.
Karen Friederike Gauß et al.
Biological age captures inter-individual heterogeneity in aging process arising from genetic and environmental influences. Metabolites, as the end-products of metabolism, integrate these factors and are therefore well suited for biological ...
Heterogeneity in Aging: Exploring Grip Strength Variability in Population-Based Age-Sex Cohorts [0.03%]
异质性衰老：基于人口的年龄-性别队列中握力变异性的探索
Richard H Fortinsky,Lisa C Barry,Katherine Zavez et al.
Richard H Fortinsky et al.
Background: Heterogeneity in aging refers to the increased variability in individual characteristics that occurs with age. Little is known about sex differences in heterogeneity in aging trends, or about longitudinal patt...