Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging [0.03%]
血清25-羟基维生素D浓度与身体质量指数联合促进基于临床生物标志物的生物学老化加速的作用关系研究
Zimo Pan,Jing Zeng,Zeyu Chen et al.
Zimo Pan et al.
Background: The possible joint association of vitamin D and obesity in regard to the clinical biomarker-based biological aging process has not been well studied. We aimed to investigate the independent and combined associ...
Multi-omics Mendelian Randomization and Single-Cell Analysis Identify Novel Therapeutic Targets for Osteosarcopenia [0.03%]
多组学孟德尔随机化和单细胞分析识别出治疗骨肌减少症的新型治疗靶点
Jiyong Yang,Miaoling Gong,Yi Zhou et al.
Jiyong Yang et al.
Background: Osteosarcopenia, defined by the coexistence of osteoporosis and sarcopenia, presents a significant health challenge for aging populations. The purpose of current study was to identify potential therapeutic tar...
Jianhong Xu,Yanxin Wang,Jonathan Ka-Long Mak et al.
Jianhong Xu et al.
Background: Hip fractures significantly increase health risks in older adults, yet the evolution of frailty before and after fracture and its impact on mortality remain unclear. This study investigated the relationship be...
Benjamin Seligman,Mark Ward,Maddalena Ferranna et al.
Benjamin Seligman et al.
Background: Frailty is a common syndrome among older adults, associated with multiple adverse health outcomes. Work harmonizing frailty measurement across 25 countries and regions and different socioeconomic environments ...
Large-Vessel Hemodynamics Are Associated with Glymphatic Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease [0.03%]
大血管血流动力学与脑小血管病中甘淋巴系统功能障碍及认知损害相关性研究
Dan Luo,Peng Zeng,Bang Zeng et al.
Dan Luo et al.
Background: Disruption of cerebral hemodynamics may impair perivascular and glymphatic clearance, contributing to aging-related brain pathology. This study aimed to explore the interaction between large-vessel hemodynamic...
A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity [0.03%]
全基因组关联研究确定了与内在能力相关的10个新型基因组位点
Melkamu B Beyene,Renuka Visvanathan,Robel Alemu et al.
Melkamu B Beyene et al.
Background: Intrinsic capacity (IC) is a multidimensional concept within the World Health Organization framework for healthy aging. It refers to the composite of an individual's physical and mental capacities that enable ...
Mismatch Between Echocardiography-predicted Cardiac Age and Chronologic Age: Insights from The Multi-Ethnic Study of Atherosclerosis [0.03%]
基于多元族裔动脉粥样硬化研究的心脏年龄与实际年龄不匹配的初步分析
Christy Zheng,Prashant Rao,Aaron Troy et al.
Christy Zheng et al.
The Association Between Bilirubin and Vestibular Dysfunction in U.S. in Middle-Aged and Elderly People Insights from NHANES 1999 - 2004 and Mendelian Randomization Analysis [0.03%]
美国成年人中胆红素与 vestibular 功能障碍的关联：来自 NHANES 1999-2004 和孟德尔随机化分析的见解
Jing Luo,Hengkang He,Fang Zhang et al.
Jing Luo et al.
Background: Vestibular dysfunction represents a significant public health burden, and the association with the endogenous antioxidant bilirubin remains controversial. This study aimed to systematically evaluate the associ...
The Health Cost of Irregular Sleep Timing: Age Differences in Social Jet Lag and Health Outcomes Among Middle-Aged and Older Adults (Brief Report) [0.03%]
不规律睡眠时间对健康的成本：中老年人群中的社会时差与健康结果的年龄差异（简报）
Eunjin Lee Tracy,Eunjung Kim,Naomi R Meinertz et al.
Eunjin Lee Tracy et al.
Background: Social jet lag, a misalignment between circadian rhythms and societal schedules, has been reported to pose significant health risks. However, evidence of social jet lag's implications on health outcomes among ...
Machine learning prediction of survival in centenarians after age 100: A retrospective, population-based cohort study [0.03%]
基于人群的队列研究中的机器学习预测百岁老人100岁以后的生存率
Jonathan K L Mak,Noel C Yue,Gloria Hoi-Yee Li et al.
Jonathan K L Mak et al.
Background: Whether survival at extreme ages can be accurately predicted remains unclear. This study explored the feasibility of using machine learning (ML) and electronic health records (EHRs) to predict mortality in cen...