A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci [0.03%]
人类胚胎干细胞全基因组筛选揭示了已知疾病位点相关的新型等位基因特异性组蛋白修饰区域
James G D Prendergast,Pin Tong,David C Hay et al.
James G D Prendergast et al.
Background: Chromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controll...
The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability [0.03%]
组蛋白H4羧端的构象灵活性可促进组蛋白八聚体、核小体以及酵母细胞稳定性
Myrriah S Chavez,Jean K Scorgie,Briana K Dennehey et al.
Myrriah S Chavez et al.
Background: The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for assembly into nucleosomes every cell cycle as well as during DNA transcription and repair. Asf1 interacts directly with H4 through the...
Hannes Lans,Jurgen A Marteijn,Wim Vermeulen
Hannes Lans
The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks. DNA damage interferes with vital processes such as transcri...
Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells [0.03%]
赖氨酸甲基转移酶G9a并非锚定DNMT3A/3B到甲基化核小体和维持体细胞DNA甲基化的必需因素
Shikhar Sharma,Daniel S Gerke,Han F Han et al.
Shikhar Sharma et al.
Background: DNA methylation, histone modifications and nucleosome occupancy act in concert for regulation of gene expression patterns in mammalian cells. Recently, G9a, a H3K9 methyltransferase, has been shown to play a r...
Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene [0.03%]
MENIN的敲低影响干扰素γ诱导的IRF1基因的前mRNA加工和启动子保真度
Lauren B Auriemma,Shaili Shah,Lara M Linden et al.
Lauren B Auriemma et al.
Background: The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription ef...
Enhancers and silencers: an integrated and simple model for their function [0.03%]
增强子和沉默子：一个简单而完整的功能模型
Petros Kolovos,Tobias A Knoch,Frank G Grosveld et al.
Petros Kolovos et al.
Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discu...
Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA [0.03%]
增强子驱动的染色质相互作用通过长非编码RNA促进转录沉默逃脱
Lisa Korostowski,Anjali Raval,Gillian Breuer et al.
Lisa Korostowski et al.
Background: Gene regulation in eukaryotes is a complex process entailing the establishment of transcriptionally silent chromatin domains interspersed with regions of active transcription. Imprinted domains consist of clus...
Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells [0.03%]
Myc和Miz-1在人胚胎干细胞中具有协调的基因组功能包括靶向HOX基因
Natalia Varlakhanova,Rebecca Cotterman,Keith Bradnam et al.
Natalia Varlakhanova et al.
Background: A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important op...
A proteomic approach for the identification of novel lysine methyltransferase substrates [0.03%]
用于新型组蛋白赖氨酸甲基转移酶底物识别的蛋白质谱学方法研究进展
Dan Levy,Chih Long Liu,Ze Yang et al.
Dan Levy et al.
Background: Signaling via protein lysine methylation has been proposed to play a central role in the regulation of many physiologic and pathologic programs. In contrast to other post-translational modifications such as ph...
Proliferating cell nuclear antigen is required for loading of the SMCX/KMD5C histone demethylase onto chromatin [0.03%]
增殖细胞核抗原需要将SMCX/KDM5C组蛋白去甲基化酶加载到染色体上
Zhihui Liang,Marc Diamond,Johanna A Smith et al.
Zhihui Liang et al.
Background: Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histo...