Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum [0.03%]
凝缩素调节小鼠小脑成熟颗粒神经元的基因组组织
Omar A Payán Parra,Ziyu Zhao,Tomoko Yamada et al.
Omar A Payán Parra et al.
Background: Proper control of gene expression is important for the development and functions of neurons in the brain. The three-dimensional organization of the genome facilitates gene expression by regulating interactions...
Antibiotics induce overexpression of alpha satellite DNA accompanied with epigenetic changes at alpha satellite arrays as well as genome-wide [0.03%]
抗生素通过表观遗传变化诱导α卫星DNA过度表达
Sven Ljubić,Maja Matulić,Damir Đermić et al.
Sven Ljubić et al.
The transcription of satellite DNA is highly sensitive to environmental factors and represents a source of genomic instability. Therefore, tight regulation of (peri)centromeric transcription is essential for genome maintenance. Antibiotics ...
Xiaobo Chen,Manjun Chen,Xingkun Gu et al.
Xiaobo Chen et al.
Epigenetic modifications, including the regulation of histone H3 lysine 4 methylation (H3K4me2/3), play critical roles in maintaining normal tissue homeostasis and influencing the progression of cancer, including growth, invasion, metastasi...
Structural DNMT-nucleosome contacts are related to DNA methylation patterns [0.03%]
DNMT-核小体接触与DNA甲基化模式相关
Kevin George,Kerstin Neininger,Anna Elizabeth Schmitz et al.
Kevin George et al.
DNA-methylation is a key epigenetic mark in chromatin that attenuates chromatin accessibility during transcription, implying a crucial role in gene regulation. Its symmetrical distribution and function is thought to be linked to the periodi...
The isoflavone genistein selectively stimulates major satellite repeat transcription in mouse heterochromatin [0.03%]
异黄酮射线刺激小鼠异染色质主要卫星重复序列的转录
Thomas Fuhrmann,Nicholas Shukeir,Reagan W Ching et al.
Thomas Fuhrmann et al.
Mouse heterochromatin is characterized by A/T-rich, 234 bp DNA repeat arrays, called major satellite repeats (MSR). We investigated MSR expression in response to a variety of stress conditions by using small molecule compounds. We identifie...
Comparison of current methods for genome-wide DNA methylation profiling [0.03%]
基因组范围DNA甲基化谱分析的当前方法比较
Ana Regina de Abreu,Joe Ibrahim,Vasileios Lemonidis et al.
Ana Regina de Abreu et al.
Background: DNA methylation is an epigenetic mechanism involved in gene regulation and cellular differentiation. Accurate and comprehensive assessment of DNA methylation patterns is thus essential for understanding their ...
Comparative Study
Epigenetics & chromatin. 2025 Aug 25;18(1):57. DOI:10.1186/s13072-025-00616-3 2025
The epigenetic circle: feedback loops in the maintenance of cellular memory [0.03%]
表观遗传循环：维持细胞记忆的反馈环路
Marko Tomljanović,Cita Hanif Muflihah,Dejan Rajkovski et al.
Marko Tomljanović et al.
The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses. Such memory is maintained through cell division as a cornerstone...
Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context [0.03%]
Slc29a3/Unc5b位点的TAD边界破坏所导致的转录变化的方向和模式取决于组织特异性的表观遗传背景
Paul Salnikov,Polina Belokopytova,Alexandra Yan et al.
Paul Salnikov et al.
Background: Topologically associating domains (TADs) are believed to play a role in the regulation of gene expression by constraining or guiding interactions between the regulatory elements. While the impact of TAD pertur...
TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation [0.03%]
TET1通过表观遗传重塑和免疫调节在肺腺癌中发挥肿瘤抑制作用
Abdur Rahim,Brian L Ruis,Andrew T Rajczewski et al.
Abdur Rahim et al.
Background: Ten-Eleven Translocation (TET1-3) dioxygenases oxidize 5-methylcytosine (5mC) in DNA to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), initiating DNA demethylat...
Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells [0.03%]
单细胞数据的多组学整合揭示骨骼肌干细胞中超增强子的甲基化特征
Anyu Zeng,Hailong Liu,Shuling He et al.
Anyu Zeng et al.
Introduction: Skeletal muscle stem cells (MuSCs) have strong regenerative abilities, but as we age, their ability to regenerate decreases, leading to a decline in muscle function. Although the methylation reprogramming of...