WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans [0.03%]
WDR-5在秀丽隐杆线虫胚胎发育过程中具有独立于H3K4甲基化作用的活性
Nurulhafizah Binti Samsudin,Siyao Wang,Kate Fisher et al.
Nurulhafizah Binti Samsudin et al.
Background: Histone H3 lysine 4 methylation (H3K4me) is generally associated with active transcription and bivalent chromatin but can also contribute to repression. In metazoans, H3K4 methylation is catalysed by KMT2 meth...
Disrupting the ASH2L-DPY30 PPI in cancer: structure, function, and therapeutic opportunities in H3K4 methylation [0.03%]
ASH2L-DPY30蛋白质相互作用在癌症中的干扰：H3K4甲基化的结构、功能和治疗机会
Emadeldin M Kamel,Ahmed A Allam,Hassan A Rudayni et al.
Emadeldin M Kamel et al.
The ASH2L-DPY30 interaction is a structurally conserved and functionally essential component of the COMPASS family of histone methyltransferases responsible for H3K4 trimethylation. This minimalist helix-groove interface plays a critical al...
The impact of fulvestrant on estrogen receptor-driven chromatin dynamics in breast cancer cells [0.03%]
氟维司群对乳腺癌细胞雌激素受体驱动的染色质动态的影响
Céline Barlier,Mathias Simplicien,Ana Hermoso et al.
Céline Barlier et al.
Background: Epigenetic dysregulations are linked to several diseases, including cancer. Among them, breast cancer is the second leading cause of cancer-related deaths in women, with 50% of mortalities attributable to estr...
All hands on DEK: structural insights into a unique histone modifier and chromatin remodeler [0.03%]
万“手”牵DEK：结构解析独特的组蛋白修饰和染色质重塑因子
E J Peters,K L Gardner,L M Privette Vinnedge
E J Peters
An RNAi-based platform for spatiotemporal control of histone gene expression during animal development [0.03%]
基于RNA干扰的平台技术实现动物发育过程中组蛋白基因时空表达调控
Oscar M Arroyo,Mary P Leatham-Jensen,Daniel J McKay
Oscar M Arroyo
Background: Mutational analysis of histones provides an important means of studying the function of histone post-translational modifications (PTMs) in epigenetic gene regulation. However, several technical challenges have...
Image-based epigenetic profiling with deep learning and high-speed super-resolution microscopy [0.03%]
基于深度学习和高速超分辨显微镜的图像表观遗传分析
Yicheng Wang,Nur Syatila Ab Ghani,Munmee Dutta et al.
Yicheng Wang et al.
High-resolution map of chromatin accessibility - insights into the focused binding of a large number of transcription factors [0.03%]
染色质开放区域高分辨率图谱与大量转录因子低占用率的关系初探
Iris Zhu,David Landsman
Iris Zhu
Background: Emerging evidence has shown the common occupancy of dozens to hundreds of transcription factors (TFs) on cis-regulatory elements (CREs), yet the underlying details are largely unknown. ...
SETDB1/ATF7IP regulate the precise genome engineering of HUSH-regulated genes [0.03%]
SETDB1/ATF7IP调控HUSH调节基因的精准基因组编辑
Brian L Ruis,Henry Ward,Chad L Myers et al.
Brian L Ruis et al.
Background: The use of programmable nucleases has transformed genome editing and functional genomics. Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) was developed such that targete...
So Youn Shin,Momtahina Tahmida,Nadejda Beliakova-Bethell et al.
So Youn Shin et al.
Major pharmacologic advances the past few decades have transformed infection with Human Immunodeficiency Virus (HIV) from a fatal disease into a chronic, manageable condition for people with access to antiretroviral therapy (ART). However, ...
Effects of topological domain disruption on transcriptional regulation are chromatin context dependent [0.03%]
拓扑关联结构域破坏的转录调控效应依赖染色质背景
Ángel Josué Cerecedo-Castillo,Diana Itzé Mojica-Santamaría,Hober Nelson Núñez-Martínez et al.
Ángel Josué Cerecedo-Castillo et al.
Background: Three-dimensional genome organization helps coordinate enhancer-promoter communication while insulating loci from inappropriate regulatory contacts. CTCF and cohesin contribute to this organization by forming ...