Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection [0.03%]
与宿主细胞相关的隐孢子虫感染生存结果的表观遗传特征
Loic Ciampossin,Arzu Ulu,Todd Lenz et al.
Loic Ciampossin et al.
Toxoplasmosis is a widespread parasitic disease affecting roughly one-third of the global population. In immunocompromised individuals or during pregnancy, infection can result in severe complications. Following primary infection, Toxoplasm...
From two to one: spatiotemporal mapping of chromatin remodelling in the protamine-lacking early zygote of zebrafish [0.03%]
从两个到一个：斑马鱼精核蛋白缺失的早期受精卵染色质重塑时空图谱
Pustovalova Eleonora,Franek Roman,Essaikiammal Sodalai Muthu Konar et al.
Pustovalova Eleonora et al.
Background: At fertilization, two highly specialized gametic genomes must rapidly reprogram into a single totipotent nucleus. In mammals, this transformation is marked by a dramatic protamine-to-histone exchange and prono...
Temporal stratification of promoter-proximal versus enhancer VDR binding directs vitamin D-responsive transcription [0.03%]
维生素D反应性转录是由启动子 proximal和增强子VDR结合的时空分层所驱动的
Priman Alfred Fau,Antonio Neme,Sabine Seuter et al.
Priman Alfred Fau et al.
Background: The active vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) activates the vitamin D receptor (VDR) in immune cells, altering the epigenome to drive diverse responses. However, how the temporal dynam...
Epigenetic deciphering of ovarian aging: multilayer interactive mechanisms and targeted reversal strategies [0.03%]
表观遗传解读卵巢衰老：多层交互机制与靶向逆转策略
Ye Zhang,Yan Yang,Qianhui Liao et al.
Ye Zhang et al.
Ovarian aging leads to the progressive loss of reproductive and endocrine functions. As an upstream regulatory hub, epigenetic modifications synergistically impair these two functions through multi-dimensional mechanisms, collectively contr...
Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing [0.03%]
DNA力学和顺式调控在模式真菌酿酒酵母基因组中对核小体定位的贡献及其在转录剪接中的作用
Guoqing Liu,Jing Cang,Zhihao Du et al.
Guoqing Liu et al.
Comparative validation of oxidative bisulfite sequencing (oxBS) and chemical-assisted pyridine borane sequencing (CAPS) protocols for locus-specific 5-hydroxymethylcytosine quantification [0.03%]
氧化态亚硫酸盐测序（oxBS）和化学辅助吡啶硼烷测序（CAPS）定量特定位点5-羟甲基胞嘧啶的比较验证方法
Katharina Pühringer,Philipp Czarda,Sebastian Iluca et al.
Katharina Pühringer et al.
Background: DNA methylation is a key regulator of tissue-specific gene expression, cell differentiation, and development. In mammals, DNA methylation predominantly occurs as 5-methylcytosine (5mC) at CpG dinucleotides. DN...
Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos [0.03%]
母体PADI6丢失会破坏小鼠晚期植入前胚胎DNA甲基化和基因组印迹维持功能
Carlo Giaccari,Francesco Cecere,Angela Pagano et al.
Carlo Giaccari et al.
Integrating single-cell transcriptomics and epigenetics in a multi-omics MR framework identifies PARK7 as a causal gene in streptococcal septicemia [0.03%]
利用多组学孟德尔随机化框架整合单细胞转录组和表观基因组分析 挖掘链球菌败血症的致病基因PARK7
Hanghang Han,Enhao Huang,Dan Liu et al.
Hanghang Han et al.
Time-course ATAC-seq and RNA-seq analysis of porcine synovium-derived mesenchymal stem cells under in vitro osteogenic induction [0.03%]
体外诱导下猪滑膜间充质干细胞的时间进程ATAC-SEQ和RNA-SEQ分析
Shuaichen Li,Puntita Siengdee,Frieder Hadlich et al.
Shuaichen Li et al.
Background: Synovium derived mesenchymal stem cells (SMSCs) are considered promising for orthopedic application due to easy accessibility and strong differentiation potential. However, the transcription factors (TFs) that...
James R Davie,Juan Ausió
James R Davie
In recent years, two seemingly unrelated topics, protein disorder and phase separation, have become highly significant in biology. In this way, intrinsically disordered proteins and liquid-liquid phase separation have become two of the hott...