Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo [0.03%]
可溶性重组tau聚集体对体内突触可塑性的离散干扰效应
Yin Yang,Tomas Ondrejcak,Neng-Wei Hu et al.
Yin Yang et al.
Neurofibrillary tangles (NFTs), composed of tau protein fibrils, together with brain inflammation and synaptic loss, are neuropathological hallmarks of several neurodegenerative diseases, including Alzheimer's disease. Compared with tau fib...
Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury [0.03%]
脊髓损伤后静脉输注间充质干细胞增加红核脊髓束轴突信号强度
Ryosuke Hirota,Masanori Sasaki,Atsushi Teramoto et al.
Ryosuke Hirota et al.
Limited spontaneous recovery occurs after spinal cord injury (SCI). However, current knowledge indicates that multiple forms of axon growth in spared axons can lead to circuit reorganization. Intravenous infusion of mesenchymal stem cells (...
Correction: Extinction of contextual fear memory is facilitated in TRPM2 knockout mice [0.03%]
纠正：TRPM2基因敲除小鼠的情境恐惧记忆消退增强
Seung Yeon Ko,Do Gyeong Kim,Huiju Lee et al.
Seung Yeon Ko et al.
Published Erratum
Molecular brain. 2025 Apr 15;18(1):34. DOI:10.1186/s13041-025-01194-x 2025
Development of Cre-dependent retrograde trans-multisynaptic tracer based on pseudorabies virus bartha strain [0.03%]
基于伪狂犬病病毒巴尔塔株的Cre依赖性逆向多突触示踪剂的开发
Hu You,Wang Qinghan,Sun Kangyixin et al.
Hu You et al.
Mapping the neural circuit of a specific neuronal subclass is central to understanding the working mechanism of the brain. Currently, numerous types of transgenic mice expressing Cre recombinase have been engineered and widely used in neuro...
Comparative experience shapes sucrose preference through memory in Drosophila [0.03%]
比较经验通过记忆塑造果蝇的蔗糖偏好反应
Maximiliano Martinez-Cordera,Takaomi Sakai,Minoru Saitoe et al.
Maximiliano Martinez-Cordera et al.
Selection of appropriate food is an ability that allows animals to make optimal foraging choices. However, the neural mechanisms that control this food selection remain unclear. The purpose of this study was to investigate the connection be...
Comparative Study
Molecular brain. 2025 Apr 10;18(1):32. DOI:10.1186/s13041-025-01202-0 2025
Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels [0.03%]
同型半胱氨酸增强培养的海马神经元兴奋性而不改变电压门控离子通道基因表达
Alzbeta Filipova,Matus Tomko,Katarina Ondacova et al.
Alzbeta Filipova et al.
Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of ex...
Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction [0.03%]
在回溯激活的神经元群体中靶向NMDA受体敲低会损害远程恐惧消退
Yongmin Sung,Dae Hee Han,Junhyuk Kim et al.
Yongmin Sung et al.
Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. Fear memory recall reactivates the consolidated fear memory trace across multiple brain regi...
Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson's disease [0.03%]
靶向氧化应激诱导的蛋白质二硫键异构酶依赖性蛋白病理性聚集：帕金森病治疗的新途径
Junshi Zhang,Tingting Liu,Haojie Wu et al.
Junshi Zhang et al.
Background: Parkinson's disease (PD), a globally prevalent neurodegenerative disorder, has been implicated with oxidative stress (OS) as a central pathomechanism. Excessive reactive oxygen species (ROS) trigger neuronal d...
Ultrastructural characterization of peri-synaptic astrocytic processes around cerebellar Purkinje spines under resting and stimulated conditions [0.03%]
小脑浦金野树突棘周围围突触天线细胞进程的超微结构特征分析——在静息和刺激条件下的比较
Jung-Hwa Tao-Cheng
Jung-Hwa Tao-Cheng
In mammalian brains, astroglia presence near glutamatergic excitatory synapses has generated the term "tripartite" junctions, based on the close association of astrocytic processes near the active zone formed by presynaptic axonal terminal ...
Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity [0.03%]
Klotho过表达可保护人类皮质神经元免受β-淀粉样蛋白诱导的神经毒性伤害
Mohammed R Shaker,Salam Salloum-Asfar,Rowaida Z Taha et al.
Mohammed R Shaker et al.
Klotho, a well-known aging suppressor protein, has been implicated in neuroprotection and the regulation of neuronal senescence. While previous studies have demonstrated its anti-aging properties in human brain organoids, its potential to m...