Deidre Jansson,Blake Highet,Susan Li et al.
Deidre Jansson et al.
Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pathway as a key modulator of in...
Junxiang Gu,Zixuan Xing,Jian Wang et al.
Junxiang Gu et al.
Autoimmune diseases (AIDs) result from intricate interactions among genetic, environmental and immune factors, with emerging evidence underscoring the role of the central nervous system (CNS) in their pathogenesis. In this study, we utilize...
Fu Shi,Luyao Lei,Jiapeng Qiu et al.
Fu Shi et al.
The cingulate cortex, on the medial cerebral hemisphere, is involved in cognitive processing, emotional regulation, nociception, voluntary motor control, and sleep modulation. Anatomically, the cingulate cortex is organized into three disti...
Unaltered empathy-related behaviors in Williams-Beuren syndrome mouse models [0.03%]
威廉姆斯贝纳综合征小鼠模型中的共情行为未改变
Dahm So,Hye Lim Cha,Sua Lee et al.
Dahm So et al.
Williams-Beuren Syndrome (WBS), a neurodevelopmental disorder caused by a heterozygous microdeletion at chromosome 7q11.23, is characterized by hypersociability and enhanced affective empathy. However, the specific genetic and neural mechan...
Changchi Hsieh,David A Cano,Panayiotis Tsokas et al.
Changchi Hsieh et al.
How can the molecules that strengthen synaptic connections maintain memory in the face of molecular turnover? Our previous work showed that persistent interaction between the postsynaptic scaffolding protein, KIBRA, and the autonomously act...
Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder [0.03%]
Shank3B缺乏通过破坏前额叶皮层锥体神经元的GABA能突触传递在自闭症光谱障碍中起作用
Heqing Yin,Ke Sun,Chenyang Wang et al.
Heqing Yin et al.
Mutations in the SHANK3B gene have been strongly implicated in the pathogenesis of autism spectrum disorder (ASD). The medial prefrontal cortex (mPFC) is integral to emotional processing and social behavior, and its atypical development is ...
Artificial intelligence-based biomarkers for the diagnosis and treatment of neurological conditions: a narrative review [0.03%]
基于人工智能的神经系统的诊断和治疗生物标志物：综述研究
Adam Ben-Jaafar,Abhishek Sinha,Princess Afia Nkrumah-Boateng et al.
Adam Ben-Jaafar et al.
Artificial intelligence (AI) is transforming biomarker discovery in neurology by overcoming key limitations of conventional approaches that are often slow, reductionist, and unable to integrate complex multimodal data. In this narrative rev...
Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons [0.03%]
TRPV2上调通过促进螺旋神经节神经元氧化应激加剧年龄相关性听力损失
Zhidong Zhang,Huan Yin,Huan Cao et al.
Zhidong Zhang et al.
Age-related hearing loss (ARHL) is a prevalent neurodegenerative condition characterized by the progressive loss of spiral ganglion neurons (SGNs). Although oxidative stress is recognized as a central pathogenic driver of ARHL, the precise ...
Intranasal administration of human mesenchymal stromal cell-derived small extracellular vesicles delays disease progression in the SOD1(G93A) mouse model [0.03%]
人源间充质基质细胞来源的小细胞外囊泡鼻内给药可延缓SOD1(G93A)小鼠模型的疾病进展
Ryosuke Hirota,Karen L Lankford,Masahito Nakazaki et al.
Ryosuke Hirota et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, with no established disease-modifying therapy. Mesenchymal stem/stromal cells (MSCs) have been reported to exert neurop...
Recapitulating Alzheimer's disease pathophysiology with a microfluidic neurospheroid-grafted endothelial barrier model [0.03%]
基于微流控神经球体-内皮屏障模型的阿尔茨海默病病理生理学研究回顾
Samuel Chidiebere Uzoechi,Charity Johnson Campbell,Cody Joseph Badeaux et al.
Samuel Chidiebere Uzoechi et al.
Background: Traditional two-dimensional (2D) models do not adequately capture the complex cellular interactions, brain-specific architecture, and progressive pathology of Alzheimer's disease (AD). Three-dimensional (3D) o...