Adenylate kinase 5, a novel genetic risk factor for Alzheimer's disease, regulates microglial inflammatory activation [0.03%]
腺苷酸激酶5通过调节小胶质细胞炎症活化成为阿尔茨海默病的新型遗传风险因子
Won Jae Seong,Sang Joon An,Jungsoo Gim et al.
Won Jae Seong et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and neuroinflammation, primarily mediated by microglia. In this study, we investigate the role of adenylate kinase 5 (AK5)...
Molecular mechanisms of gut microbiota dysbiosis and metabolites in Alzheimer's disease pathogenesis: implications for precision therapeutics [0.03%]
肠道微生物群失调及其代谢物在阿尔茨海默病发病机制中的分子机理：精准治疗的启示
Yashar Vaziri,Jaleh Bagheri Hamzyan Olia,Cigir Biray Avci et al.
Yashar Vaziri et al.
Alzheimer's disease (AD) originates from both central and peripheral pathways. The gut microbiota is a clear risk factor. In AD, microbiota imbalances drive immune system activation, disrupt protective barriers, and alter neuromodulatory si...
Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [0.03%]
发育性脑病态神经节苷脂：对神经发育障碍的意义
Jennifer M Ackerman,Thomas James L Ford,Shraddha Shridhar Kattewar et al.
Jennifer M Ackerman et al.
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies. PNNs are dense extracellular matrix structures primarily found in the central nervous ...
Deficiency of SARM1 attenuates neuronal injury and improves neurological performance in a photothrombotic stroke model [0.03%]
SARM1不足可减轻光化学脑卒中模型中的神经元损伤并改善神经功能缺陷
Yanjie Huang,Xiaofeng Cheng,Ke Yan et al.
Yanjie Huang et al.
Stroke is a major cause of morbidity and mortality worldwide. There is an urgent need for effective neuroprotective agents to reduce brain injury. SARM1 (sterile alpha and TIR motif-containing 1) has been identified as a key mediator of axo...
Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice [0.03%]
药理学上通过苏泽特林抑制NaV1.8小鼠表现出强烈的止痛潜力且不会形成耐受性
Md Yousof Ali,Flavia T T Antunes,Sun Huang et al.
Md Yousof Ali et al.
The Voltage-gated sodium channel NaV1.8 is a critical determinant of nociceptive signaling in primary sensory neurons. Here, we evaluated the analgesic potential of suzetrigine, a potent clinically approved NaV1.8 blocker, using electrophys...
Septin5 deficiency impairs both recent and remote contextual fear memory [0.03%]
Septin5缺乏影响近期和远期情境恐惧记忆
Natsumi Ageta-Ishihara,Naoto Fukumasu,Kodai Sakakibara et al.
Natsumi Ageta-Ishihara et al.
Septin-3 and Septin-5 are components of the septin cytoskeleton highly expressed in the nervous system, yet the extent of their shared and distinct roles is not fully understood. We recently demonstrated that Septin-3 regulates late-phase l...
Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway [0.03%]
脑神经营养液通过调节线粒体功能和CREB/PGC-1α通路缓解氯胺酮介导的焦虑和认知障碍
Leila Hosseini,Nasrin Abolhasanpour,Fatemehsadat Seyedaghamiri et al.
Leila Hosseini et al.
Schizophrenia is known as a complex and devastating mental disorder due to its profound impact on individuals, families, and society. Emerging evidence proposes that mitochondria play a central role in schizophrenia. Here, we investigated w...
Abnormal behaviors and glial responses in an animal model of tau pathology [0.03%]
Tau病理动物模型中的异常行为和胶质细胞反应
Yue Liu,Akira Sobue,Naruhiko Sahara et al.
Yue Liu et al.
Tau hyperphosphorylation has been considered a major contributor to neurodegeneration in Alzheimer's disease (AD) and frontotemporal dementia, and related tauopathies have gained prominence in the development of therapies for these conditio...
Gpr176 modulates the firing pattern of parvalbumin-positive interneurons in the orbitofrontal cortex of mouse [0.03%]
Orbitofrontal皮层中的Gpr176调控parvalbumin阳性中间神经元的放电模式
Jing Tian,Ziran Huang,Wen Zhang
Jing Tian
Parvalbumin-positive (PV+) interneurons are the most abundant type of interneurons in the cortex. Its characteristic high-frequency non-accommodating firing pattern is critical for cortical inhibition, network activity, and mouse behavior. ...
Striatal transcriptomic alterations immediately after short-term abstinence from methamphetamine self-administration in rats [0.03%]
短期安非他明自给结束后大鼠纹状体转录组改变
Won-Jun Jang,Sang-Hoon Song,Taekwon Son et al.
Won-Jun Jang et al.
Substance use disorders, particularly drug addiction, are complex neurophysiological conditions characterized by cycles of compulsive drug use, withdrawal symptoms, and relapses. Methamphetamine (MA) addiction evolves through repeated expos...