Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories [0.03%]
化学遗传学激活组胺神经元可促进看似已丢失的记忆的检索
Yuto Yokoi,Ayame Kubo,Kyoka Nishimura et al.
Yuto Yokoi et al.
Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the brain, as shown by their occasional spontaneous retrieval. Histamine in the central nervous ...
Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens [0.03%]
生长激素分泌促效剂受体在大鼠伏隔核的存在及其形态学分布可视化研究
Seohyeon Lee,Wen Ting Cai,Hyung Shin Yoon et al.
Seohyeon Lee et al.
The potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in regulating drug addiction and feeding has been documented; however, the pattern of its express...
Adolescent chemogenetic activation of dopaminergic neurons leads to reversible decreases in amphetamine-induced stereotypic behavior [0.03%]
青少年化学遗传学激活多巴胺能神经元可导致amphetamine引起的刻板行为的逆转减少
Muhammad O Chohan,Amy B Lewandowski,Rebecca N Siegel et al.
Muhammad O Chohan et al.
Chronic perturbations of neuronal activity can evoke homeostatic and new setpoints for neurotransmission. Using chemogenetics to probe the relationship between neuronal cell types and behavior, we recently found reversible decreases in dopa...
Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation [0.03%]
对新环境的探索可使体内海马区GluA1(Ser831)磷酸化、S6K活化和Arc表达，类似于体内长期增强的作用
Roberta Cagnetta,Jean-Claude Lacaille,Nahum Sonenberg
Roberta Cagnetta
The brain responds to experience through modulation of synaptic transmission, that is synaptic plasticity. An increase in the strength of synaptic transmission is manifested as long-term potentiation (LTP), while a decrease in the strength ...
Globus pallidus is not independent from striatal direct pathway neurons: an up-to-date review [0.03%]
苍白球并非纹状体直接通路神经元的独立组分——最新研究进展综述
Fumino Fujiyama,Fuyuki Karube,Yasuharu Hirai
Fumino Fujiyama
Striatal projection neurons, which are classified into two groups-direct and indirect pathway neurons, play a pivotal role in our understanding of the brain's functionality. Conventional models propose that these two pathways operate indepe...
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner [0.03%]
TDP43以DNA损伤诱导的方式与MLH1和MSH6蛋白相互作用
Vincent E Provasek,Manohar Kodavati,Brandon Kim et al.
Vincent E Provasek et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA bindi...
Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice [0.03%]
前额叶皮层中前列腺素不足的小鼠树突棘头部直径减小
Anna K Cook,Kelsey M Greathouse,Phaedra N Manuel et al.
Anna K Cook et al.
Loss-of-function mutations in the progranulin (GRN) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically result in haploinsufficiency of the progranulin protein. Grn+/- mice provide a model for pr...
Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells [0.03%]
慢性不可预测压力诱导成年海马神经干细胞发生自噬性死亡
Seongwon Choe,Hyeonjeong Jeong,Jieun Choi et al.
Seongwon Choe et al.
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous results show that chronic restraint stress causes cognitive deficits and mood dysregulation by i...
Hypothalamic protein profiling from mice subjected to social defeat stress [0.03%]
社交挫败应激小鼠下丘脑蛋白质图谱分析
Shiladitya Mitra,Ghantasala S Sameer Kumar,Anumita Samanta et al.
Shiladitya Mitra et al.
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body and the brain. We analysed hypothalamic proteome from mice subjected to chronic social defeat...
María Teresa Vega-Ramírez,Enrique Becerril-Villanueva,José Luis Maldonado-García et al.
María Teresa Vega-Ramírez et al.
Fibromyalgia (FM) is a chronic condition that causes widespread pain, fatigue, and other symptoms that significantly affect quality of life. The underlying mechanisms of fibromyalgia involve both the immune system and the central nervous sy...