Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice
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Loss-of-function mutations in the progranulin (GRN) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically result in haploinsufficiency of the progranulin protein. Grn+/- mice provide a model for progranulin haploinsuf... ...
