Tsutomu Sasaki
Tsutomu Sasaki
Obesity and alcoholism are major global health burdens driven in part by maladaptive ingestive behaviors. Accordingly, functional foods that curb overeating and excessive alcohol consumption may help prevent these disorders. Ingestion of si...
Lysosomes and Supersulfides: Emerging Links in Cellular Metabolism and Homeostasis [0.03%]
溶酶体与超硫化物：细胞代谢和稳态的新兴联系
Natsumi Sakata,Takaaki Akaike,Hozumi Motohashi
Natsumi Sakata
Supersulfides, a class of catenated sulfur-containing biomolecules, are increasingly recognized as key regulators of redox signaling, mitochondrial function, and inflammatory responses. Recent evidence suggests that lysosomes, central organ...
Establishment of prohaptoglobin-specific antibody and haptoglobin detection systems as biomarkers for pancreatic diseases [0.03%]
建立针对前血红素结合蛋白的特异性抗体和血红素结合蛋白检测系统作为胰腺疾病的生物标志物
Daisuke Sakon,Jumpei Kondo,Kayoko Shimizu et al.
Daisuke Sakon et al.
Fucosylated haptoglobin (Fuc-Hp) has been recognized as a cancer-associated glycoform. We previously established a monoclonal antibody, 10-7G mAb, which detects both Fuc-Hp and its precursor prohaptoglobin (proHp). Recent studies have sugge...
Proteomics and Synaptome Mapping to Uncover Diversity in Excitatory Synapses [0.03%]
利用蛋白质组学和突触组定位法发掘兴奋性突触的多样性
Takeshi Kaizuka
Takeshi Kaizuka
Synapses are the fundamental computational units of the brain. Although synapses are classically classified according to the neurotransmitter they use, glutamatergic excitatory synapses also exhibit marked heterogeneity in their molecular c...
ATP-generating activity of the ADP-forming acetyl-CoA synthetase in free-living microaerophilic fornicates, Aduncisulcus paluster and Kipferlia bialata [0.03%]
微需氧独立生活的固氮纤毛虫Fornix palustris、Aduncisulcus paluster和Kipferlia bialata的ADP形成型乙酰辅酶A合成酶活性
Toshitaka Koganemaru,Yoshitaka Tamura,Yasutaka Hoshi et al.
Toshitaka Koganemaru et al.
Fornicata is a group of eukaryotes adapted to anaerobic and microaerophilic environments. These organisms generate ATP anaerobically through substrate-level phosphorylation. ADP-forming acetyl-CoA synthetase (ACS) is one of the key enzymes ...
Preferential formation of Nω-(carboxyethyl)arginine from methylglyoxal and its accumulation in human lens proteins [0.03%]
甲基甘油醛与精氨酸反应形成Nω-(羧乙基)精氨酸并积累在人晶状体蛋白中
Himeno Takahashi,Mime Nagai,Tsuyoshi Ikeda et al.
Himeno Takahashi et al.
Methylglyoxal (MGO), a highly reactive dicarbonyl compound generated mainly by glycolysis, is a major precursor of advanced glycation end products (AGEs). Although lysine-derived AGEs, such as Nε-(carboxyethyl)lysine (CEL), have been widel...
Replacement of non-canonical interloop disulfide bond of alpaca VHH by hydrophobic amino acids [0.03%]
通过疏水性氨基酸替换骆驼VHH非典型互锁二硫键
Yoko Akazawa-Ogawa,Lilian Kaede Komaba,Hideki Watanabe et al.
Yoko Akazawa-Ogawa et al.
Non-canonical disulfide bonds are a hallmark of the VHH domain of heavy-chain antibodies, with predominant bonds between CDRs 1 and 3 and between framework FR2 and CDR3. The former interloop disulfide bond is advantageous for stability and ...
TGF-β downregulates E-cadherin expression via a novel ZEB1-dependent mechanism [0.03%]
转化生长因子β通过一个新的ZEB1依赖机制下调E-钙黏着蛋白的表达
Shigeo Otake,Yuka Itoh,Masao Saitoh et al.
Shigeo Otake et al.
Zinc finger E-box-binding homeobox 1 (ZEB1) is a core transcription factor regulating epithelial-mesenchymal transition (EMT), and its high expression is associated with malignant cancer phenotypes and a poor prognosis. ZEB1 mediates downre...
Estrogen-related receptor γ functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment [0.03%]
雌激素受体γ通过破坏雄激素受体构象和阻止共激活剂募集成为雄激素受体的新别构抑制剂
Xiaohui Liu,Kaisei Koga,Masahiro Noguchi et al.
Xiaohui Liu et al.
Estrogen-related receptor γ (ERRγ) is an orphan nuclear receptor whose molecular functions in transcriptional regulation remain incompletely understood. The androgen receptor (AR) is a ligand-dependent transcription factor that plays a pi...
Tamaki Suganuma,Jerry L Workman
Tamaki Suganuma
Metabolism is a complex consortium of chemical reactions, consuming and releasing energy. In addition, cellular respiration is a pivotal catabolic process of nutrients using oxygen to generate ATP. Dynamics of chromatin structure are fundam...