Preferential formation of Nω-(carboxyethyl)arginine from methylglyoxal and its accumulation in human lens proteins
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Methylglyoxal (MGO), a highly reactive dicarbonyl compound generated mainly by glycolysis, is a major precursor of advanced glycation end products (AGEs). Although lysine-derived AGEs, such as Nε-(carboxyethyl)lysine (CEL), have been widely used as markers of... ...